I've been following Ethan Suplee's weight loss transformation for a while now, and he's been more active on social media talking about it since January of 2020 when his American Glutton podcast premiered. He had Layne Norton and Mark Bell as guests, among others.
In this interview, Ethan Suplee goes into a little more detail about his former drug addiction - he was addicted to heroin and cocaine while he was at his fattest, which was around 550-lb at 6'2" [he maxed out a 536-lb shipping scale at one point, and may have been over that weight at that time, and gained some weight from there]. According to Ethan, he was addicted to drugs in the Ironage photo below, where he weighed around 550-lb.
The article here which features that photo said that he had congestive heart failure in 2001, when he was 24, but I have never heard him talk about that anywhere:
https://www.today.com/health/ethan-suplee-weight-loss-actor-went-550-255-pounds-t206343