Getbig.com: American Bodybuilding, Fitness and Figure
Getbig Main Boards => Gossip & Opinions => Topic started by: The True Adonis on July 05, 2007, 05:19:56 PM
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(http://farm2.static.flickr.com/1341/727663041_63325260bf.jpg?v=0)
Big Wendy the muscular whippet
Rare genetic mutation increases muscles, weight of sleek breed
Kim Westad, Times Colonist
Published: Monday, June 25, 2007
People mistake her for a pitbull with a pinhead, but Wendy the whippet is one rare breed.
So rare that the Central Saanich dog recently graced the New York Times. She also had several of her photos shown on The Today Show, all because of a rare genetic mutation that has led to her being the Incredible Hulk of dogs.
Wendy is a 27-kilogram rippling mass of muscle. Forget the so-called six-pack stomach: Wendy has a 24-pack. And the muscles around her neck are so thick, they look like a lion's ruff.
Wendy the Whippet has a genetic disorder that has resulted in an exceptionally muscular appearance.
Bruce Stotesbury, Times Colonist
"People have referred to her as Arnold Schwarzenegger," says doting owner Ingrid Hansen, stroking Wendy's sleek black coat and white chest.
Wendy was recently part of a genetics study done in the U.S. on mutation in the myostatin gene in whippets, which resemble greyhounds in appearance. The National Institute of Health study reported that whippets with one single defective copy of the gene have increased muscle mass that can enhance racing performance in the breed, known for speeds up to 60 kilometres an hour.
But whippets with two mutated copies of the gene become "double-muscled," like Wendy. It has been seen before in one human, and also in mice, cattle and sheep, says the study.
The uber-muscled whippets are called "bullies," not because of their nature -- Wendy likes nothing better than a good back scratch and isn't shy about sitting in your lap to ask for one -- but because of their size. She's about twice the weight of an average whippet, but with the same height and small narrow head -- and the same size heart and lungs, which means she probably won't live as long as normal whippets.
Hansen has had Wendy, now four, since she bought the dog from a Shawnigan Lake breeder when she was eight months old.
Wendy landed in clover. She lives on an acreage, runs around with other dogs and horses, sleeps on Hansen's bed and pretty much anywhere else she wants to.
People are often afraid when the muscle-bound dog runs up to them on her dainty whippet-thin legs, but they soon realize she's friendly, Hansen said.
© Times Colonist (Victoria) 2007
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haha damn and i thaught my am. stafford was buff. this much muscle on that goofy ass head looks weird, that dog looks like a rat. hmmm only 27 kg, pure muscle, 1 % bodyfat, never saw veins on a dog.
ALL DRUGS
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Freaky!
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haha damn and i thaught my am. stafford was buff. this much muscle on that goofy ass head looks weird, that dog looks like a rat. hmmm only 27 kg, pure muscle, 1 % bodyfat, never saw veins on a dog.
ALL DRUGS
My dog has veins!
(http://petget.com/prh/files/d3_391.jpg)
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Must be all that Iron Cross training those dogs are doing.
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Must be all that Iron Cross training those dogs are doing.
Darwin is very lean and muscular. We train a few days a week together.
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???
(http://s192.photobucket.com/albums/z255/spinwall/biggesthousecatever.jpg)
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My dog has veins!
Tell us some more about your veiny dog...it's so interesting...how veiny is it's prick?
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My dog has veins!
(http://petget.com/prh/files/d3_391.jpg)
you know that dog looks a lot like you.
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Dude is that real!!?? That is insane..WIsh they would find a way for us to block myostatin in our bodies..
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Dude is that real!!?? That is insane..WIsh they would find a way for us to block myostatin in our bodies..
IT is being worked on. The hard thing is, is finding a limit that will agree with the respiratory system. Too big and the heart will fail.
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Here is a Normal Whippet compared to the genetic bully Whippet.
(http://farm2.static.flickr.com/1341/727663041_63325260bf.jpg?v=0)
(http://www.dog.com/breed/docgrafx/Whippet.jpg)
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Digg.
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Dude is that real!!?? That is insane..WIsh they would find a way for us to block myostatin in our bodies..
There is a way....you just viewed the results (muscular dog) of the way in which it is being done. Troubling point...TOO MUCH MUSCLE CAN BE FATAL. The blocked myostatin cause the heart, lungs, internal organs and all muscles to grow too large and since the heart can not function normally in this enlarged state it fails. All animals that have had this done to it soon die. You would do better taking some DBOL, TEST, DECA or something..
BTW I hope you don't believe this BULLSHIT that this dog just happened to be born without this gene??? This animal is another scientific experiment if ever there was...First mice, then rats, then cows, then dogs..oh yeah I forgot there was supposedly a German baby that was born without the gene...hmmmlemme see that was a couple of years ago...this should be one buffed kid and impossible to hide...where is he now???
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Dude is that real!!?? That is insane..WIsh they would find a way for us to block myostatin in our bodies..
if that happens, the bodybuilding world would be dead. Then everybody can be big. Its much better like it is, if someone gets big its all his work. It would evn be better if there wasnt no drugs.
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Breeding dogs to these ideals is wrong.
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There is a way....you just viewed the results (muscular dog) of the way in which it is being done. Troubling point...TOO MUCH MUSCLE CAN BE FATAL. The blocked myostatin cause the heart, lungs, internal organs and all muscles to grow too large and since the heart can not function normally in this enlarged state it fails. All animals that have had this done to it soon die. You would do better taking some DBOL, TEST, DECA or something..
BTW I hope you don't believe this BULLSHIT that this dog just happened to be born without this gene??? This animal is another scientific experiment if ever there was...First mice, then rats, then cows, then dogs..oh yeah I forgot there was supposedly a German baby that was born without the gene...hmmmlemme see that was a couple of years ago...this should be one buffed kid and impossible to hide...where is he now???
The German Kid is normal now and shows NO signs of any difference of a normal child his age.
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if that happens, the bodybuilding world would be dead. Then everybody can be big. Its much better like it is, if someone gets big its all his work. It would evn be better if there wasnt no drugs.
every human can run does that mean they shouldn't have marathons? You're thick as a brick and about 1/2 as interesting
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The dog at the top looks better than most of the Ms. Olympia contestants.
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i gotta get me one of those
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i gotta get me one of those
great physique in the avatar.
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My dog has veins!
(http://petget.com/prh/files/d3_391.jpg)
Your dog is a skinny mongrel, same as you :D
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(http://farm2.static.flickr.com/1341/727663041_63325260bf.jpg?v=0)
Wow what a magnificent animal. I can only imagine how explosive she would be in a short sprint.
She looks much better proportioned in this pic then in some of the other ones I have seen of her.
Imagine breeding this phenotype into a Japanese Akita, or a Golden Retriever, or.....a Grey Hound, now that would be a site to behold.
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My dog has veins!
(http://petget.com/prh/files/d3_391.jpg)
Your dog look's like the crack head version of the 1st dog!
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The German Kid is normal now and shows NO signs of any difference of a normal child his age.
Including muscle huh? I'd be interested in a link if you have one. I'd also love to know how the Wyeth study on MYO-29 turned out. They finished it a year ago and haven't released findings yet. Drug development is sooooo slow, thank god The Singularity is Near.
The Belgian blues, and the mighty mice don't have shorter lifespans do they? I'm curious as to why you and the authors of this article predict respiratory trouble for Wendy, is there data suggesting that it is a likely outcome?
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(http://farm2.static.flickr.com/1341/727663041_63325260bf.jpg?v=0)
That's the freakiest looking dog I've ever seen. It looks like some kind of lab experiment or cartoon character come to life. I wonder if all that muscle is functional or if it's so muscle bound that it has a hard time doing the typical activities normal to the Whippet breed.
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(http://farm2.static.flickr.com/1341/727663041_63325260bf.jpg?v=0)
That's the freakiest looking dog I've ever seen. It looks like some kind of lab experiment or cartoon character come to life. I wonder if all that muscle is functional or if it's so muscle bound that it has a hard time doing the typical activities normal to the Whippet breed.
they are faster out of the blocks but lack the stamina for the normal distance 200m sprints I believe. Also may lack the aggressive character, they tend to be very docile.
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Including muscle huh? I'd be interested in a link if you have one. I'd also love to know how the Wyeth study on MYO-29 turned out. They finished it a year ago and haven't released findings yet. Drug development is sooooo slow, thank god The Singularity is Near.
The Belgian blues, and the mighty mice don't have shorter lifespans do they? I'm curious as to why you and the authors of this article predict respiratory trouble for Wendy, is there data suggesting that it is a likely outcome?
http://www.detnews.com/apps/pbcs.dll/article?AID=/20070607/METRO/706070357/1003
This is current and is a different person than the German baby.
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they are faster out of the blocks but lack the stamina for the normal distance 200m sprints I believe. Also may lack the aggressive character, they tend to be very docile.
This should shed some light on what Wyeth is doing and a little on the German boy who is no longer stronger than normal:
Superbaby Serum
Matthew Herper 02.26.07
Related Quotes
WYE 57.35 - 0.13
A brawny infant's mutation has set off a hunt for a muscular dystrophy drug.
The child was the talk of the Neonatal Ward at Charite Hospital in Berlin, Germany. His biceps and and thighs were twice as thick as a normal newborn's despite typical height and weight. He looked like he'd been lifting weights in the womb.
This was in 2000. The child's doctor called in pediatric neurologist and geneticist Markus Schuelke. He thought the boy might have had a muscular disease but then remembered that Se-Jin Lee, a Johns Hopkins University geneticist, had produced overly buff mice by knocking out the gene for a protein called myostatin, which is supposed to slow muscle growth. Schuelke thought here was the first evidence of a myostatin mutation in a human.
Four years later the world heard about the boy for the first time, when a group of researchers including Schuelke and Lee proved the boy had a myostatin mutation. By then the child could hold a 7-pound dumbbell in each of his outstretched hands. One writer to the New England Journal of Medicine speculated that the mythical Hercules was a myostatin mutant, too.
The news about this rare mutation precipitated an intensive effort to design drugs--call them myostatin blockers--that would let muscles flourish without onerous side effects. The work holds the most promise for patients with Duchenne muscular dystrophy, a debilitating and deadly disease diagnosed in 600 American children, almost all boys, every year. Corticosteroids and heart-failure drugs have allowed some patients to survive into their 40s, but they are still strapped to ventilators and require round-the-clock care.
"This is a like a bright light in a fairly dark tunnel," says Patricia Furlong, founder of Parent Project Muscular Dystrophy. She lost two teenage sons to Duchenne. The research also offers hope for patients with Lou Gehrig's disease and age-related weakening.
Myostatin was discovered in mice in 1992 in Lee's Johns Hopkins lab. In 1996 he proved its importance by showing that mice without the myostatin-producing gene got twice as big. The next year he discovered that the bulging Belgian Blue cow was a myostatin mutant, the first of eight prized cattle breeds later found to have the mutation. The company he had cofounded, MetaMorphix, is working on manipulating myostatin to beef up livestock. Wyeth (nyse: WYE - news - people ) picked up the rights to develop a drug for humans. Its experimental antibody drug produced bulked-up mice in 2002, and results of a trial in adults with muscular dystrophy are expected as early as March.
Already there are concerns that the drugs might be used by athletes as a kind of supersteroid, and dietary-supplement companies have introduced knockoffs made from sea algae for that purpose. "They don't work," says Schuelke.
Schuelke and Lee still see room for failure. Side effects could crop up, and Lee's work shows that real muscle growth may require a broader attack than the Wyeth drug's targeted approach, because there are a host of mysterious myostatin-like proteins that also dampen muscle growth. Lee doesn't know how many. Acceleron Pharma is set to begin human trials on a drug that mimics a cell receptor that could disable many of the myostatin-like proteins. The Cambridge, Mass. firm has raised $56 million from venture funds, including Polaris Venture Partners and OrbiMed Advisors.
Schuelke continues to see the muscular boy he found in Berlin seven years ago. Though there were fears that his heart might get too thick, the boy is completely healthy. He's strong but no longer abnormally so. It may be that myostatin's effects are most dramatic during fetal development, but that's one of many guesses in this genetic mystery.
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Here is something that might help an Experimenting bodybuilder or Dog Genotyper, cattle breeder
http://www.metamorphixinc.com/
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they are faster out of the blocks but lack the stamina for the normal distance 200m sprints I believe. Also may lack the aggressive character, they tend to be very docile.
They? There's more than one of these super muscular Whippets?
Can this dog Wendy function normally or is she so musclebound that she can't run or play like a normal Whippet? I almost feel bad for her.
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They? There's more than one of these super muscular Whippets?
Can this dog Wendy function normally or is she so musclebound that she can't run or play like a normal Whippet? I almost feel bad for her.
Of course there is more. Its not a freak occurrence since we know how to breed a "Bully Whippet". She is normal but is hindered by her size of course. Her heart may not be able to take the mass. Keep in mind she is a little over twice the size of a normal Whippet, but the heart is the same size.
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http://www.nytimes.com/2007/06/12/science/12dog.html?ex=1183867200&en=b420135758ec365f&ei=5070 (http://www.nytimes.com/2007/06/12/science/12dog.html?ex=1183867200&en=b420135758ec365f&ei=5070)
(http://graphics8.nytimes.com/images/2007/06/11/us/12dog-600.jpg)
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this would make a cool pet:
(http://www.fahad.com/pics/liger.jpg)
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this would make a cool pet:
(http://www.fahad.com/pics/liger.jpg)
A Liger eh?
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A Liger eh?
Yep that's what it is... It's pretty much my favorite animal. It's like a lion and a tiger mixed... bred for its skills in magic. Close to a thousands pounds.
http://www.metacafe.com/watch/250400/liger/
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Will do a lot of damage on the pro circuit once the whippet brings up its foreaerms and calves.
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every human can run does that mean they shouldn't have marathons? You're thick as a brick and about 1/2 as interesting
you cant compare it like that, running is workig ,like lifting. whats myostatin? nothing! you dont have to do jack shit after myosttin.
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I don't get it.....this is supposed to be kinda a BB board, they have a petboard don't they? why do we have to see pics of a ripped dog every week?
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I don't get it.....this is supposed to be kinda a BB board, they have a petboard don't they? why do we have to see pics of a ripped dog every week?
Because the bitch has wheels dog.
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I don't get it.....this is supposed to be kinda a BB board, they have a petboard don't they? why do we have to see pics of a ripped dog every week?
Are you retarded------------how do you not see how this relates to BBing???
This is talking about extreme muscular development through pure genetics--not training, not drugs, just mutated DNA that causes extreme development.
I find this thread fascinating, this is far more interesting than argueing about dorian vs. coleman.
Good Job Adonis-----keep this stuff coming
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Sh1T!!!!!! That dog does look like the mutant one in the incredible hulk movie. Absolutely incredible muscle mass.
How many cases has this happened in humans? Just the two kids? It would be so interesting to see what someone with those genes could do as a natural bodybuilder.
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Are you retarded------------how do you not see how this relates to BBing???
This is talking about extreme muscular development through pure genetics--not training, not drugs, just mutated DNA that causes extreme development.
I find this thread fascinating, this is far more interesting than argueing about dorian vs. coleman.
Good Job Adonis-----keep this stuff coming
until they do this in humans I don't see the point, wow a muscle bound dog...great, wonderful. I saw a pic of a cow or a bull with this condition 5 years ago and I didn't get to fired up and seeing a dog with it was interesting at first but now there's a new thread on it every week. I just don't get it.
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That Dog would beat Coleman and Cutler on the most muscular Pose anytime ;D .damn, Imagine a german sherpherd with a genetic mutation like this one.
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Because the bitch has wheels dog.
LOL
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until they do this in humans I don't see the point, wow a muscle bound dog...great, wonderful. I saw a pic of a cow or a bull with this condition 5 years ago and I didn't get to fired up and seeing a dog with it was interesting at first but now there's a new thread on it every week. I just don't get it.
Al are you paying any attention, they are working on a drug to block myostatin in Humans, they have done human trials, and some even say it is available on the black market. I know one of your major goals here is to antagonize TA (and me because you think I agree with him too much) but I thought that your primary reason for being here was because you are interested in muscle development. Can't you see that this thread is more relevant to muscle development then just about anything else that gets posted here?
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until they do this in humans I don't see the point, wow a muscle bound dog...great, wonderful. I saw a pic of a cow or a bull with this condition 5 years ago and I didn't get to fired up and seeing a dog with it was interesting at first but now there's a new thread on it every week. I just don't get it.
DID U READ THE ARTICLE-----IT HAS ALREADY HAPPENED IN HUMANS!!!!!
Its only a matter of time before they figure out exactly why and how to replicate the mutation in humans. Although signifigant progress wont be made on that until President Bush is out of office.
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Al are you paying any attention, they are working on a drug to block myostatin in Humans, they have done human trials, and some even say it is available on the black market. I know one of your major goals here is to antagonize TA (and me because you think I agree with him too much) but I thought that your primary reason for being here was because you are interested in muscle development. Can't you see that this thread is more relevant to muscle development then just about anything else that gets posted here?
exaclty---your TA obession is blinding you to true signifigance of this information.
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Al are you paying any attention, they are working on a drug to block myostatin in Humans, they have done human trials, and some even say it is available on the black market. I know one of your major goals here is to antagonize TA (and me because you think I agree with him too much) but I thought that your primary reason for being here was because you are interested in muscle development. Can't you see that this thread is more relevant to muscle development then just about anything else that gets posted here?
I don't worry a whole lot about TA, if it's relevent to you guys go for it I guess. whould this really be something a "natural" guy would be allowed to use if it happens and is availible? Is it any different than roids? these are honest questions...not that it matters much I guess.
if I was just here to go after you and TA I'd actually put some effort into it, simply asking "what's the point of posting pics of your dog" isn't really going after anyone, is it? I'm def. not here to go after you again if I was I'd put effort into it instead of an occasional post here and there, have I been vicious with you? no, I don't think so.
I've seen at least 4 threads about this in the last few weeks is all I was saying.
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http://www.detnews.com/apps/pbcs.dll/article?AID=/20070607/METRO/706070357/1003
This is current and is a different person than the German baby.
Yeah I read about him...he is only heterozygous for the mutation and he still was almost able to do an iron cross at 19 months.
It would be too bad if the gene had diminished effect in adults.
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Epic unnatural animal lust thread :o
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whould this really be something a "natural" guy would be allowed to use if it happens and is availible? Is it any different than roids?
I have no attachment to being natural, just to being healthy. I will improve my body with any technologies that become available so long as they do not negatively impact my longevity or longterm health. Steroids are unhealthy, so I don't use them, the impact of Myostatin inhibition on humans remains to be seen.
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adonis what do you sudgest to get my dogg more buff. treadmill? here a few pics.
Cute pooch. what's his/her name?
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Schuelke continues to see the muscular boy he found in Berlin seven years ago. Though there were fears that his heart might get too thick, the boy is completely healthy. He's strong but no longer abnormally so. It may be that myostatin's effects are most dramatic during fetal development, but that's one of many guesses in this genetic mystery.
I call bullshit. That doctor is lying through his teeth. Dollars for donuts, kid looks like a freak of nature.