Steroids & 'G6PD Deficiency'

[Monster81]

 my training partner has finally decided to start his first cycle (test & d-bol).
But he has something called “G6PD deficiency” its something related to the blood , im not sure if this could be a problem or if steroids will affect his blood/health in anyway…!!!
he has recently done a blood test (blood sugar, cholesterol, pressure) and everything is just fine.
So whats ur opinion on that , will he be safe using steroids ?
thx...

[Vet]

Thats a pretty serious disease.  I'd think it could open up a whole lot of problems, especially if drugs like insulin or HGH were used.   Hell, certian antibiotics can virtually kill people with G6PD deficiency.

[emn1964]

Good news is that he's resistant to malaria!

[England_1]

G6PD is the lacking of the enzyme that converts glucose to glucose-6-P. The addition of the phosphate group is what keeps your glucose inside your cells. I don't remember how it's treated.

[NeverTrustABlonde]

G6PD is the lacking of the enzyme that converts glucose to glucose-6-P. The addition of the phosphate group is what keeps your glucose inside your cells. I don't remember how it's treated.

It can be managed, as long as you stay away from certain drugs, foods, etc... lack of this enzyme makes the red blood cells sensitive to oxidative stress. Other than playing a role in the conversion of glucose, G6PD is also responsible for keeping NADPH in the cell (which converts peroxide to water), lack of this makes the cell unstable and prone to lysis under oxidative stress.... which can lead to hemolytic anemia, which can usually be fixed by removing the trigger... or something along those lines...

[Vet]

It can be managed, as long as you stay away from certain drugs, foods, etc... lack of this enzyme makes the red blood cells sensitive to oxidative stress. Other than playing a role in the conversion of glucose, G6PD is also responsible for keeping NADPH in the cell (which converts peroxide to water), lack of this makes the cell unstable and prone to lysis under oxidative stress.... which can lead to hemolytic anemia, which can usually be fixed by removing the trigger... or something along those lines...

Thats basically my understanding of the disease. 

[NeverTrustABlonde]

since steroids are broken down by a completely different enzyme... it wouldn't cause a problem, but in theory... since steroids have a positive effect on blood cell production, a person who is at a danger of developing anemia would benefit from the extra blood cell production.... right?

[Monster81]

since steroids are broken down by a completely different enzyme... it wouldn't cause a problem, but in theory... since steroids have a positive effect on blood cell production, a person who is at a danger of developing anemia would benefit from the extra blood cell production.... right?

good point

[emn1964]

Just stay the fuck away from fava beans!!!!

[England_1]

NADPH in the cell (which converts peroxide to water)

NADPH has nothing to do with conversion of peroxide, that's catalase.

[NeverTrustABlonde]

NADPH has nothing to do with conversion of peroxide, that's catalase.

not an expert.... sorry.... but it has something to do with it indirectly.... it promotes some kind of anti-oxidant activity... so the peroxide does eventually get converted to water... as i understand

[England_1]

not an expert.... sorry.... but it has something to do with it indirectly.... it promotes some kind of anti-oxidant activity... so the peroxide does eventually get converted to water... as i understand

of course, it can donate an electron pair (reduction)

[Monster81]

So, i forwarded my question to 'Dave Palumbo', and here is what he answered:

The steroids will have no interaction with that enzyme deficiency!
YES, G6PD is an enzyme deficiency disease whereby the RBC's cannot process carbohydrates properly and thus can lead to their death (hemolytic anemia). This should no interaction with anabolic steroids.

i guess NeverTrustABlonde was right , but the issue of this disease elemenating carbohydrates to be processed proprly worries me, since carbohydrates plays an importand role of building muscles as u know,, which means that he will never make it as a good/successfull bber !

[NeverTrustABlonde]

So, i forwarded my question to 'Dave Palumbo', and here is what he answered:

i guess NeverTrustABlonde was right , but the issue of this disease elemenating carbohydrates to be processed proprly worries me, since carbohydrates plays an importand role of building muscles as u know,, which means that he will never make it as a good/successfull bber !

not carbohydrates all together, there are other pathways...
a best the blood cells are just.... not as efficient

[DIVISION]

my training partner has finally decided to start his first cycle (test & d-bol).
But he has something called “G6PD deficiency” its something related to the blood , im not sure if this could be a problem or if steroids will affect his blood/health in anyway…!!!
he has recently done a blood test (blood sugar, cholesterol, pressure) and everything is just fine.
So whats ur opinion on that , will he be safe using steroids ?
thx...

Bodybuilding will not be in his future.

DNP will definitely not be in his future.



DIV