For hypertrophy, do a few sets of 8-10 reps not to failure (you could call these warmup sets), adding weight each time until you get to a weight where you have to really work, then take the last set to max reps in the range of 8-12 reps.
Some might call this "one set training" as only the final set is taken to the limit.
Simple.
This is the way I trained when starting out and it worked pretty well.