Prominent players diagnosed with ALS include:
Steve Gleason: Former New Orleans Saints safety, diagnosed in 2011, who became a prominent advocate for ALS research through Team Gleason.
Steve McMichael: Chicago Bears Hall of Fame defensive tackle, diagnosed in 2021, who passed away from the disease in 2025.
Tim Green: Former Atlanta Falcons linebacker and author, diagnosed in 2016.
Tim Shaw: Former Tennessee Titans linebacker, who revealed his diagnosis during the 2014 Ice Bucket Challenge.
O.J. Brigance: Former Baltimore Ravens linebacker, diagnosed in 2007.
Kevin Turner: Former Philadelphia Eagles and New England Patriots fullback, who passed away in 2016.
Dwight Clark: Former San Francisco 49ers wide receiver, who publicly announced his diagnosis in 2017 and passed away in 2018.
The ALS Association
Research conducted by organizations such as the Boston University CTE Center has found strong evidence linking repetitive head trauma from football to an increased risk of developing ALS.