I loved the Mike Tyson one, as well as the Super Nintendo one.
The new Punchout forced me to buy a Wii just 2 days ago, as I got one used and the game for $200. Loving it so far.
When I get it online, I will download the original punchout and the SNES one for like $8 a piece. Gotta get the Mario Kart too.
Just to keep this thread bodybuilding related, Super MachoMan would have made a great bodybuilder if he could have brought up his legs a little.