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Getbig Bodybuilding Boards => Nutrition, Products & Supplements Info => Topic started by: Bluto on December 12, 2008, 01:14:44 PM
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Whats your thoughts/experience on Melatonin?
Pros/cons ?
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It always gave me a headache & left me with a "hungover" feeling.
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i take a sublingual version whenever i feel like i'll need some help to fall asleep.. it's cheap and i find it somewhat effective
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i take 9 mg with zinc and magnesium every night.
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i take 9 mg with zinc and magnesium every night.
what happens then
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what happens then
Crazy brain activity in dreams. It's an entertaining night of sleep.
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Crazy brain activity in dreams. It's an entertaining night of sleep.
We can start a thread down at the Z board where people on zma can tell about their dreams
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i dont notice any different dreams i just take it cuz it5 makes me go to sleep and if i dont take ity ill lay in bed for an hour or two before i do go to sleep.. plus the melatonin helps release gh
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i take 9 mg with zinc and magnesium every night.
Wow thats quite a dose..
WE cant buy it off the shelf any more , so I asked my doc for a script and he wouldnt give it to me , said it has been linked to neurological problems..I didnt push him for an explanation.
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at costco i get bottles with 300 3mg tabs for like 6 bucks..
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My best results have come from Source Natural's timed release sublingual Melatonin spray. I sleep very well on that but the highest I usually go is 3-5 mg. The non -timed release versions tend to wear off in the middle of the night for me. I also take a potent liquid alcohol extract of Kava before bed as well. I had insomnia many years ago pretty bad, but this formula works well. Does increase my dream activity which I like because I'm into something called Lucid Dreaming...but that's another story.
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My best results have come from Source Natural's timed release sublingual Melatonin spray. I sleep very well on that but the highest I usually go is 3-5 mg. The non -timed release versions tend to wear off in the middle of the night for me. I also take a potent liquid alcohol extract of Kava before bed as well. I had insomnia many years ago pretty bad, but this formula works well. Does increase my dream activity which I like because I'm into something called Lucid Dreaming...but that's another story.
What happens when it wears off, do you wake up?
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What happens when it wears off, do you wake up?
Yeah and I still wake up sometimes on the time release to go take a whizz or something..the difference is I fall back to sleep right away, where on the regular, it might take me longer.
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But there's a downside to it I guess since its not allowed everywhere?
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Melatonin's a nice, more moderate alternative to sleeping pills. It's milder, isn't as strong so it doesn't stay in the system as long and doesn't always work but often does.
If taking pills, have to experiment with doses. 3 mg is on the light side but start there, work up to around 6 mg if needed. Liquid melatonin's a little more effective but rarer. Sprays i've never heard of but i suspect are closer to liquid versions.
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My best results have come from Source Natural's timed release sublingual Melatonin spray. I sleep very well on that but the highest I usually go is 3-5 mg. The non -timed release versions tend to wear off in the middle of the night for me. I also take a potent liquid alcohol extract of Kava before bed as well. I had insomnia many years ago pretty bad, but this formula works well. Does increase my dream activity which I like because I'm into something called Lucid Dreaming...but that's another story.
I may be wrong on this but doesn't a "time release" have to be a pill or capsule rather than a spray. How can you slow the release of a liquid? Know what I mean? If it works great, it just may not make a difference as opposed to any other spray or sublingual form.
As for lucid dreams I have read about that, where you are aware that you are dreaming. Have you experienced this? On some level I'm not sure I'd want to experience that but it sounds kinda cool.
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its good stuff...make sure u are in darkness for a bit before bed cuz i heard darkness helps with uptakes of it
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good for sleep
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I may be wrong on this but doesn't a "time release" have to be a pill or capsule rather than a spray. How can you slow the release of a liquid? Know what I mean? If it works great, it just may not make a difference as opposed to any other spray or sublingual form.
As for lucid dreams I have read about that, where you are aware that you are dreaming. Have you experienced this? On some level I'm not sure I'd want to experience that but it sounds kinda cool.
Here's from Source Naturals PDF File:
The First Timed Release Sublingual
Due to the multi-layered structure of the tiny lipospheres,
nutrients are gradually released for extended
periods of time, maintaining optimal dosage throughout
the day or night. This combined with a faster onset
of the active ingredients – usually within 15 minutes –
makes NUTRASPRAY the most bioavailable delivery system
for nutritional supplements today, and the first
truly timed release sublingual.
The lipid micro-encapsulation process is based on
years of research in liposomal technology. The result is
NUTRASPRAY, a proprietary system to deliver nutrients
in the most efficient manner. This sublingual oral
spray is a liquid suspension of liposomes, which are
nutrients encased in very complex microscopic lipid
spheres, 1/50th the diameter of a human hair. A highly
purified natural lecithin forms the membrane of
these lipid spheres, which are able to move easily
through the lipid environment surrounding the capillaries
in the mouth. Lipospheres then gradually release their nutrients into bloodstream.
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As for lucid dreams I have read about that, where you are aware that you are dreaming. Have you experienced this? On some level I'm not sure I'd want to experience that but it sounds kinda cool.
Yes, I do it quite often. It is becoming aware that you are dreaming. At the moment of awareness, the dream takes on a much higher level of clarity..picture if you will, a dream in "High Definition". Also, you can taste, smell and feel things almost like in the real world. I have found that it's useful to recite certain goals and affirmations in the Lucid dream state since you can directly program your subconscious mind that way and quickly assume the charateristics of your affirmations. Also you can vividly experience dream sex, dream flying, whatever you want.
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:o
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also try l-theanine, its a precursor to melatonin and also helps with sleep.
a buddy of mine takes melatonin before exercise because its been proven to release growth hormone and no its doesnt make him sleepy because melatonin is activated by darkness for the sleepy part
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the dose that would be worth taking is 300mcg that is micrograms. taking 6-9mgs is retarded, it is a hormone and you are functional messing with circadian rthyms, serotonin production etc... Not to mention possibly inducing depression at those doses. The point is to aid in sleep onset and reduce latency. MG ranges are way to high for most people and have some consequences.
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Never tried it - isn't it supposed to make you horny?
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the dose that would be worth taking is 300mcg that is micrograms. taking 6-9mgs is retarded, it is a hormone and you are functional messing with circadian rthyms, serotonin production etc... Not to mention possibly inducing depression at those doses. The point is to aid in sleep onset and reduce latency. MG ranges are way to high for most people and have some consequences.
for real ????
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for real ????
yes. it is known to induce depression and fuck up cognition at high doses. It may treat cancer and has some immune modulating effects. I wouldnt go crazy with it though. It regulates your circadian clock, just stay on the lower end.
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Yes, I do it quite often. It is becoming aware that you are dreaming. At the moment of awareness, the dream takes on a much higher level of clarity..picture if you will, a dream in "High Definition". Also, you can taste, smell and feel things almost like in the real world. I have found that it's useful to recite certain goals and affirmations in the Lucid dream state since you can directly program your subconscious mind that way and quickly assume the charateristics of your affirmations. Also you can vividly experience dream sex, dream flying, whatever you want.
Sorry were getting off topic about the melatonin but this sounds interesting. So how do you actually achieve this in the dream? Any negatives effects to doing this that you can tell?
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Sorry were getting off topic about the melatonin but this sounds interesting. So how do you actually achieve this in the dream? Any negatives effects to doing this that you can tell?
Here is a good resource with a FAQ page on the subject.
http://www.lucidity.com/LucidDreamingFAQ2.html
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Just drink your own urine in the morning. At least the middle 2 cups from the first piss, warm and straight.
It will restore proper melatonin/serotonin balance, giving you a drastically improved ability to control your mind however you desire.
If you want to focus more, you'll be able to focus more. If you want to rest, you'll be able to rest. You'll be able to do anything. ;)
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Just drink your own urine in the morning. At least the middle 2 cups from the first piss, warm and straight.
It will restore proper melatonin/serotonin balance, giving you a drastically improved ability to control your mind however you desire.
If you want to focus more, you'll be able to focus more. If you want to rest, you'll be able to rest. You'll be able to do anything. ;)
Could you provide a link to a double blind scientific study that backs your claim please?
Thanks, little buddy. :)
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Could you provide a link to a double blind scientific study that backs your claim please?
Thanks, little buddy. :)
Randomly-sampled, randomly-assigned participants, reliable double-blind experiments that involve control and experimental groups, not involving self-report, constructing chi-squares in order to account for and analyze all potential factors and conditions surrounding the independent and dependent variable(s) in order to draw valid correlations and predictions, possibly plotting their points on a scatter plot then drawing the graph for visual representation, eliminating all potential placebo and hawthorne effects throughout this entire process, determining both effect size and power, finally calculating z-scores and/or t-scores, in order to ultimately--ULTIMATELY--
arrive at a valid rejection or acceptance of the null hypothesis. ;)
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Randomly-sampled, randomly-assigned participants, reliable double-blind experiments that involve control and experimental groups, not involving self-report, constructing chi-squares in order to account for and analyze all potential factors and conditions surrounding the independent and dependent variable(s) in order to draw valid correlations and predictions, eliminating all potential placebo and hawthorne effects in the process, determining both effect size and power, finally calculating z-scores and/or t-scores, in order to ultimately--ULTIMATELY--
arrive at a valid rejection or acceptance of the null hypothesis. ;)
Yes, those kinds of studies........post some links.
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Yes, those kinds of studies........post some links.
lol, i dont even know why he posted that blurb about statistics.
the references he provided were not supporting his thesis and the studies that have been done show no benefit. I like how it cures all disease, if you have cystic fibrosis it will cure the nacl fuckup and fix your genes, piss is that good.
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lol, i dont even know why he posted that blurb about statistics.
the references he provided were not supporting his thesis and the studies that have been done show no benefit. I like how it cures all disease, if you have cystic fibrosis it will cure the nacl fuckup and fix your genes, piss is that good.
EVERY LAST STUDY ON URINE THERAPY SHOWS NOTHING BUT BENEFITS.
NOT ONE SINGLE STUDY ON URINE THERAPY SHOWS ANY HARMFUL SIDE EFFECTS WHATSOEVER.
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EVERY LAST STUDY ON URINE THERAPY SHOWS NOTHING BUT BENEFITS.
NOT ONE SINGLE STUDY ON URINE THERAPY SHOWS ANY HARMFUL SIDE EFFECTS WHATSOEVER.
Nor is there one scientific study that shows benefits.
BTW, meltdown. :-*
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Nor is there one scientific study that shows benefits.
BTW, meltdown. :-*
False statement. We've discussed this extensively. You've been provided sources which provide sources you can look into yourself. YOU can go to a university's library and look into it yourself. It's all there waiting for you, THOUSANDS of "scientific studies" on the topic that show MIRACULOUS BENEFITS.
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False statement. We've discussed this extensively. You've been provided sources which provide sources you can look into yourself. YOU can go to a university's library and look into it yourself. It's all there waiting for you, THOUSANDS of "scientific studies" on the topic that show MIRACULOUS BENEFITS.
Yeah, I spent the day at the library, I got the papercuts to prove it >:( ......I would like you to provide me with a more current study, one that does not utilize antique technology. ;)
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Yeah, I spent the day at the library, I got the papercuts to prove it >:( ......I would like you to provide me with a more current study, one that does not utilize antique technology. ;)
People = "antique technology?"
The point at which urine therapy quit being researched sufficiently is the point at which it became necessary to do research that has commercial interests in order to receive funding from PEOPLE WHO WOULD MAKE MONEY OFF OF THE RESEARCH.
How the fuck are you going to tell someone to pay you for their own piss?
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People = "antique technology?"
The point at which urine therapy quit being researched sufficiently is the point at which it became necessary to do research that has commercial interests in order to receive funding from PEOPLE WHO WOULD MAKE MONEY OFF OF THE RESEARCH.
How the fuck are you going to tell someone to pay you for their own piss?
it quit being researched because it showed no benefit.
I beleive chaos posted a link to the cancer society quoting studies showing no benefit.
You have yet to provide one real reference,except some case report from 1937, of people saying piss cured them. Then you posted a slue of studies that i researched and posted, most of which had nothing to do with drinking urine, not even remotely similar.
It doesn't work.
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People = "antique technology?"
The point at which urine therapy quit being researched sufficiently is the point at which it became necessary to do research that has commercial interests in order to receive funding from PEOPLE WHO WOULD MAKE MONEY OFF OF THE RESEARCH.
How the fuck are you going to tell someone to pay you for their own piss?
That is your only argument? That the medical companies don't want the info out there because they can't charge you for it? LOL, weak and you know it.
Every medical study I have seen has said the same thing, in small amounts it's harmless but also not going to benefit you anymore than eating regular food throughout the day.
If it makes you feel better to drink piss, go right ahead, but why push it on other people?
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People = "antique technology?"
The point at which urine therapy quit being researched sufficiently is the point at which it became necessary to do research that has commercial interests in order to receive funding from PEOPLE WHO WOULD MAKE MONEY OFF OF THE RESEARCH.
How the fuck are you going to tell someone to pay you for their own piss?
didnt you post a video of a guy charging to register to his piss drinking forum?
kinda hypocritical.
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That is your only argument? That the medical companies don't want the info out there because they can't charge you for it? LOL, weak and you know it.
Every medical study I have seen has said the same thing, in small amounts it's harmless but also not going to benefit you anymore than eating regular food throughout the day.
If it makes you feel better to drink piss, go right ahead, but why push it on other people?
I talked to you about that streisen bitch, you agreed, WTF!?!
That's wishful thinking, only hearing what you want, you know better, chaos.
Every last study shows nothing but miraclulous benefits.
I'm not pushing it onto other people. But when someone has a problem that can be solved with it, urine therapy should certainly be mentioned. It's out of respect for the person with the problem and out of care for other human beings. I don't give one fuck about "pushing" something onto people, but I do feel obligated to let them know if it can help them.
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I talked to you about that streisen bitch, you agreed, WTF!?!
That's wishful thinking, only hearing what you want, you know better, chaos.
Every last study shows nothing but miraclulous benefits.
I'm not pushing it onto other people. But when someone has a problem that can be solved with it, urine therapy should certainly be mentioned. It's out of respect for the person with the problem and out of care for other human beings. I don't give one fuck about "pushing" something onto people, but I do feel obligated to let them know if it can help them.
post more on piss and melatonin.
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I talked to you about that streisen bitch, you agreed, WTF!?!
That's wishful thinking, only hearing what you want, you know better, chaos.
Every last study shows nothing but miraclulous benefits.
I'm not pushing it onto other people. But when someone has a problem that can be solved with it, urine therapy should certainly be mentioned. It's out of respect for the person with the problem and out of care for other human beings. I don't give one fuck about "pushing" something onto people, but I do feel obligated to let them know if it can help them.
Not one study I have read shows "miraclulous benefits", in fact the studies I've read say it won't kill you but it won't help you either........so you are using people's testimonies as facts and you know better than that.
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The only good thing piss is for is in german porn movies.
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Not one study I have read shows "miraclulous benefits", in fact the studies I've read say it won't kill you but it won't help you either........so you are using people's testimonies as facts and you know better than that.
Self-report studies are NOT acceptable, chaos. We're talking about:
1) People who believe something is supposed to happen. (PLACEBO) and
2) People who know they're being observed. (HAWTHORNE)
Both of these will fuck up the experiment, so I'm sorry but--FAIL.
Self-report studies are not reliable nor valid. What you need is a double-blind study with random selection, random assignment, etc...
We've discussed this extensively. ;)
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Self-report studies are NOT acceptable, chaos. We're talking about:
1) People who believe something is supposed to happen. (PLACEBO) and
2) People who know they're being observed. (HAWTHORNE)
Both of these will fuck up the experiment, so I'm sorry but--FAIL.
Self-report studies are not reliable nor valid. What you need is a double-blind study with random selection, random assignment, etc...We've discussed this extensively. ;)
Thanks for proving my point. Unless you can post a "double blind study with random selection, random assignment, etc..... " then you and your 1930's library "research" are blowing smoke. ;)
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Self-report studies are NOT acceptable, chaos. We're talking about:
1) People who believe something is supposed to happen. (PLACEBO) and
2) People who know they're being observed. (HAWTHORNE)
Both of these will fuck up the experiment, so I'm sorry but--FAIL.
Self-report studies are not reliable nor valid. What you need is a double-blind study with random selection, random assignment, etc...
We've discussed this extensively. ;)
If you beleive..post a vid of YOU drinking Your Piss..its simple. :)
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Thanks for proving my point. Unless you can post a "double blind study with random selection, random assignment, etc..... " then you and your 1930's library "research" are blowing smoke. ;)
You do realize they would have had to disprove it in order for it to be "blowing smoke," right?
It's still valid. What it is not is POPULAR. ;) This won't make anyone money. $$$ :-\ $$$
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You do realize they would have had to disprove it in order for it to be "blowing smoke," right?
It's still valid. What it is not is POPULAR. ;) This won't make anyone money. $$$ :-\ $$$
I believe in the medical world you have to prove it's validity more than anything else. Until then *puff* away. ;)
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I believe in the medical world you have to prove it's validity more than anything else. Until then *puff* away. ;)
You first need the funding to do the research. ;) Research today is for the most part commercially driven and has been for decades.
"Validity" is only a judgement on whether or not a study is measuring what it claims it does. For instance, it may not make sense, or there may be a lurking variable (something else influencing the results) you are not aware of. You may be claiming you've shown something you did not. In that case it would not be "valid."
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You first need the funding to do the research. ;) Research today is for the most part commercially driven and has been for decades.
"Validity" is only a judgement on whether or not a study is measuring what it claims it does. For instance, it may not make sense, or there may be a lurking variable (something else influencing the results) you are not aware of. You may be claiming you've shown something you did not. In that case it would not be "valid."
i have no idea what you are blabbering about. Proper methodology reduces extraneous variables, science is predicated on this. Keep the thread on topic, on the topic of melatonin. I dont mind some off topic banter but you are just making ridiculous claims now.
Start another thread about piss if you like. :D
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i have no idea what you are blabbering about. Proper methodology reduces extraneous variables, science is predicated on this. Keep the thread on topic, on the topic of melatonin. I dont mind some off topic banter but you are just making ridiculous claims now.
Start another thread about piss if you like. :D
Just because you personally don't realize something that doesn't make that thing you don't realize a "ridiculous claim."
You don't know it yet. Accept that and learn.
Are you aware of Type I and Type II errors and how frequently they occur despite "proper methodology?"
WTF, if you think "proper methodology" eliminates error it's obvious you're very amateur, Necrosis. ::)
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Just so you guys know melatonin is a precurser to Estrogen. My wife was taking it to help sleep at night. Then she started to get really bitchy, and was 8 days late on her period. Take at your own risk.
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Just so you guys know melatonin is a precurser to Estrogen. My wife was taking it to help sleep at night. Then she started to get really bitchy, and was 8 days late on her period. Take at your own risk.
I had the same sides ;D
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Just because you personally don't realize something that doesn't make that thing you don't realize a "ridiculous claim."
You don't know it yet. Accept that and learn.
Are you aware of Type I and Type II errors and how frequently they occur despite "proper methodology?"
WTF, if you think "proper methodology" eliminates error it's obvious you're very amateur, Necrosis. ::)
i have done advanced statistics courses, clinical research courses and you are wrong. Proper methodology reduces error as much as possible and a well designed study, with proper power, double blind rct eliminates most error, especially with drug trials.
you are no left to arguing that the negative studies are flawed..... weak.
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I would recommend Melatonin to anyone who is trying to improve the quality of their sleep.
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i have done advanced statistics courses, clinical research courses and you are wrong. Proper methodology reduces error as much as possible and a well designed study, with proper power, double blind rct eliminates most error, especially with drug trials.
you are no left to arguing that the negative studies are flawed..... weak.
i now think i'm going to have a lucid nightmare of an upper level stats class i took last fall thanks to this thread
i'm waiting on this soundness guy to claim piss has anabolic properties next
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the dose that would be worth taking is 300mcg that is micrograms. .
Ridiculous. Mg is the dose on any bottle found in stores you idiot.
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Ridiculous. Mg is the dose on any bottle found in stores you idiot.
BWHAHAHHAHAHA........... . MELTDOWNNNNNNNNNNNNNNNNN NNNN
thats because the brands you buy are shit, also because you are stupid and have no knowledge of nutrition or training.
dont melt again.
Hope you can read....
http://web.mit.edu/newsoffice/2001/melatonin-1017.html
"According to our research, the physiological dose of melatonin of about 0.3 milligrams restores sleep in adults over the age of 50," said Wurtman, lead investigator in the study. "The adults who would normally wake up during the second and third thirds of the night were able to sleep through the night with the 0.3 milligram dosage."
OH NOESSSSSSSSSSS
"The researchers also discovered that the typical health food store dosage of melatonin, which is about three milligrams (or 10 times the dosage in the study), is less effective in treating insomnia. In addition, the higher dosage can cause potentially serious side effects, including hypothermia (low body temperature). The study also showed that the higher dosage elevated plasma melatonin levels during the day, which can cause a "hangover" effect in some of the subjects"
watch your mouth convict
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BWHAHAHHAHAHA............ MELTDOWNNNNNNNNNNNNNNNNN NNNN
thats because the brands you buy are shit, also because you are stupid and have no knowledge of nutrition or training.
dont melt again.
Hope you can read....
http://web.mit.edu/newsoffice/2001/melatonin-1017.html
"According to our research, the physiological dose of melatonin of about 0.3 milligrams restores sleep in adults over the age of 50," said Wurtman, lead investigator in the study. "The adults who would normally wake up during the second and third thirds of the night were able to sleep through the night with the 0.3 milligram dosage."
OH NOESSSSSSSSSSS
"The researchers also discovered that the typical health food store dosage of melatonin, which is about three milligrams (or 10 times the dosage in the study), is less effective in treating insomnia. In addition, the higher dosage can cause potentially serious side effects, including hypothermia (low body temperature). The study also showed that the higher dosage elevated plasma melatonin levels during the day, which can cause a "hangover" effect in some of the subjects"
watch your mouth convict
Great post mate
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Great post mate
thanks, normally i wouldnt be such as ass on this board but pumpster seems to be a habitual know-it-all asshole. He is a habitual line stepper.
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EXACTLY! Did you catch Necrosis' sorry ass reply's and epic inability to learn and comprehend? ::) ;D
Learning from others' personal experience is heresay, not scientific.
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EXACTLY! Did you catch Necrosis' sorry ass reply's and epic inability to learn and comprehend? ::) ;D
Necrosis = a good guy, and he = Gary Busey approved.
You = approved as well, for your initiative in the piss. :)
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I cant seem to find a bad word about melatonin, or anyone saying 3mg or higher is a high dose.
you sure you on top of this necro ?
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BWHAHAHHAHAHA............ MELTDOWNNNNNNNNNNNNNNNNN NNNN
thats because the brands you buy are shit, also because you are stupid and have no knowledge of nutrition or training.
dont melt again.
Hope you can read....
http://web.mit.edu/newsoffice/2001/melatonin-1017.html
"According to our research, the physiological dose of melatonin of about 0.3 milligrams restores sleep in adults over the age of 50," said Wurtman, lead investigator in the study. "The adults who would normally wake up during the second and third thirds of the night were able to sleep through the night with the 0.3 milligram dosage."
OH NOESSSSSSSSSSS
"The researchers also discovered that the typical health food store dosage of melatonin, which is about three milligrams (or 10 times the dosage in the study), is less effective in treating insomnia. In addition, the higher dosage can cause potentially serious side effects, including hypothermia (low body temperature). The study also showed that the higher dosage elevated plasma melatonin levels during the day, which can cause a "hangover" effect in some of the subjects"
watch your mouth convict
That's happened to me almost everytime I've taken it.
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thats a pretty old study, 2001. i wonder if there's been plenty of more since then and if their conclusions are the same
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ill try my luck with pubmed but so far ive only found a study about jetlag:
Comparative study to determine the optimal melatonin dosage form for the alleviation of jet lag.
To compare the impact of various dosage forms of melatonin and placebo on jet lag symptoms, 320 volunteers who had flights over 6 to 8 time zones were recruited for a double-blind, randomized, placebo-controlled study. The volunteers received either melatonin 0.5-mg fast-release (FR) formulation, melatonin 5-mg FR formulation, melatonin 2-mg controlled-release (CR) formulation, or placebo. The study medication was taken once daily at bedtime during 4 days after an eastward flight. The volunteers completed the Profile of Mood States (POMS), sleep log, and symptoms questionnaires once daily and the Karolinska Sleepiness Scale (KSS) three times daily prior to departure and during the 4 days of medication intake postflight. A total of 234 (73.1%) participants were compliant and completed the study. The FR melatonin formulations were more effective than the slow-release formulation. The 5-mg FR formulation significantly improved the self-rated sleep quality (p < .05), shortened sleep latency (p < .05), and reduced fatigue and daytime sleepiness (p < .05) after intercontinental flight. The lower physiological dose of 0.5 mg was almost as effective as the pharmacological dose of 5.0 mg. Only the hypnotic properties of melatonin, sleep quality and sleep latency, were significantly greater with the 5.0-mg dose.
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I also found a study of retards :D
Mentally retarded people typically exhibit poor sleep efficiency and reduced nocturnal plasma melatonin levels. The daytime administration of oral melatonin to those people, in doses that raise their plasma melatonin levels to the nocturnal range, can accelerate sleep onset. We examined the ability of similar, physiological doses to restore nighttime melatonin levels and sleep efficiency in mentally retarded subjects with sleep deficits. In a double-blind, placebo-controlled study, mentally retarded subjects (n = 20) received, in randomized order, a placebo and two melatonin doses (0.1, and 3.0 mg) orally 30 minutes before bedtime for a week. Treatments were separated by 1-week washout periods. Sleep data were obtained by polysomnography on the last three nights of each treatment period. The physiologic melatonin dose (0.3 mg) restored sleep efficiency (p < 0.0001), acting principally in the midthird of the night; it also elevated plasma melatonin levels (p < 0.0008) to normal. The lowest dose (0.1 mg) also improved sleep.
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I forgot to mention that not only did she get bitchy, and was late on her period. Her boobs got bigger and swollen. This might be great for the ladies, but in guys this might increase the chance of a gyno.
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to crack this one back open. i cant take this stuff anymore i sleep like im in a coma all day and night and have the most wild dreams!
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Any new studies on melatonin? Somewhere I read its a miracle substance, somewhere they say its dangerous. I am running out of it, and now I am considering should I buy more or not.
Lately I take it every night, 3mg dosage since months, no side effects.
Btw I am 22 y/o male, and I can sleep without it.
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I cant seem to find a bad word about melatonin, or anyone saying 3mg or higher is a high dose.
you sure you on top of this necro ?
ya for sleep induction and quality the lower dose seems to work best. However, there have been studies with melatonin in the close to gram range for long periods showing no ill effects. Also, im not against taking higher doses as i once stated, after continual usuage the next day hypersomnolence is gone. Also, it is a potent antioxidant and with the safety data higher doses offer potential health benefits. I mentioned this before but for people with GERD, you may want to try 6-9 mgs of melatonin a day to reduce symptoms, it is quite effective and validated by research. There has been quite a bit of research on cancer and melatonin and the possible treatment of such. I think it is a great supplement and if treating solely insomnia, i would still recommend the lower dosing.
Hypertens Res. 2009 Oct 30. [Epub ahead of print]
Melatonin for nondippers with coronary artery disease: assessment of blood pressure profile and heart rate variability.
Rechciński T, Trzos E, Wierzbowska-Drabik K, Krzemińska-Pakuła M, Kurpesa M.
Department of Cardiology, Biegański Hospital, Medical University of Lodz, Lodz, Poland.
The aim of this study was to assess the effects of 5 mg melatonin before sleep in patients with coronary artery disease (CAD) and with an abnormal circadian pattern of blood pressure (BP) on changes in circadian BP profile and heart rate variability (HRV). Sixty patients with CAD, nondippers aged 48-80 years (male 75%), were included. In addition to previous treatment, they were randomly allocated to melatonin or placebo. After 90 days, a second 24-h BP monitoring was carried out. Each patient had two sessions (before randomization and at the end of study) of 24-h ECG monitoring to assess the changes in HRV. Inclusion of melatonin led to BP pattern normalization in 35% of patients in the melatonin group and in 15% of controls (P=0.609). This effect was reached not only by a decrease in nighttime BP, but also by an increase in daytime BP (significant in the melatonin group). A nonoptimal effect for BP profile was observed in 12.5% of patients: extreme- or reverse dippers. In patients with conversion from nondippers to dippers (responders), an increase in standard deviation of normal-to-normal intervals between initial and final HRV analyses was observed. Nonresponders represented an increase in the mean circadian heart rate. To avoid nonoptimal effects, the inclusion of melatonin in pharmacotherapy of patients with CAD should be based on monitoring of circadian BP profile, before and during treatment. As melatonin caused not only a nocturnal decrease in BP but also a daytime increase, it should not be recommended in patients with 'high normal' values of BP because of the danger of induction of arterial hypertension.Hypertensio n Research advance online publication, 30 October 2009; doi:10.1038/hr.2009.174
melatonin and its relationship to blood pressure. Sorry guys there is a shit ton of research but im so sedated right now i dont think i can weed through it much more. If anyone wants more info on melatonin or research for general knowledge just request it. i have absolutely no problem helping, i rather enjoy learning about possible therapies.
Postepy Hig Med Dosw (Online). 2009 Sep 15;63:425-34.
[MT1 melatonin receptors and their role in the oncostatic action of melatonin]
[Article in Polish]
Danielczyk K, Dziegiel P.
Katedra i Zakład Histologii i Embriologii Akademii Medycznej im. Piastów Slaskich we Wrocławiu.
Melatonin, the main hormone produced by the pineal gland, strongly inhibits the growth of cancer cells in vitro and in vivo. Some publications indicate that the addition of melatonin to culture medium slows the proliferation of some cancer cell lines. It is also suggested that melatonin used as an adjuvant benefits the effectiveness and tolerance of chemotherapy. The mechanisms of this are not fully understood, but melatonin receptors might be one of the most important elements. Two distinct types of membrane-bound melatonin receptors have been identified in humans: MT1 (Mel1a) and MT2 (Mel1b) receptors. These subtypes are 60% homologous at the amino-acid level. MT1 receptors are G-protein-coupled receptors. Through the a subunit of G protein, melatonin receptors stimulate an adenylate cyclase and decrease the level of cAMP. This has a significant influence on cell proliferation and has been confirmed in many tests on different cell lines, such as S-19, B-16 murine melanoma cells, and breast cancer cells. It seems that expression of the MT1 melatonin receptors benefits the efficacy of melatonin treatment. Melatonin and its receptors may provide a promising way to establish new alternative therapeutic approaches in human cancer prevention.
some research on cancer(above and below).
Br J Cancer. 2009 Nov 3;101(9):1613-9. Epub 2009 Sep 22.
Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expression and activity in breast cancer cells.
Martínez-Campa C, González A, Mediavilla MD, Alonso-González C, Alvarez-García V, Sánchez-Barceló EJ, Cos S.
Department of Physiology and Pharmacology, School of Medicine, University of Cantabria, 39011 Santander, Spain.
BACKGROUND: Melatonin reduces the development of breast cancer interfering with oestrogen-signalling pathways, and also inhibits aromatase activity and expression. Our objective was to study the promoters through which melatonin modifies aromatase expression, evaluate the ability of melatonin to regulate cyclooxygenases and assess whether the effects of melatonin are related to its effects on intracellular cAMP, in MCF-7 cells. METHODS: Total aromatase mRNA, aromatase mRNA promoter regions and cyclooxygenases mRNA expression were determined by real-time RT-PCR. PGE(2) and cAMP were measured by kits. RESULTS: Melatonin downregulated the gene expression of the two major specific aromatase promoter regions, pII and pI.3, and also that of the aromatase promoter region pI.4. Melatonin 1 nM was able to counteract the stimulatory effect of tetradecanoyl phorbol acetate on PGE(2) production and inhibit COX-2 and COX-1 mRNA expression. Melatonin 1 nM elicited a parallel time-dependent decrease in both cyclic AMP formation and aromatase mRNA expression. CONCLUSIONS: This study shows that melatonin inhibits aromatase activity and expression by regulating the gene expression of specific aromatase promoter regions. A possible mechanism for these effects would be the regulation by melatonin of intracellular cAMP levels, mediated by an inhibition of cyclooxygenase activity and expression.
cool thing about this study is it confirms that melatonin is an anti-estrogen via inhibiting testosterone aromatization. Anyway i want to examine the role of melatonin on GH production as topically it is synergistic with GH in osteoblastic(bone building) activity. I have a look tom, im zonked.