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Getbig Main Boards => Gossip & Opinions => Topic started by: calfzilla on January 03, 2015, 01:51:18 AM
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Which one would it be?
For me probably yohimbe. I feel like I'm about to have a stroke and die when I take that shit. :-X
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Definitely Super HD. I tried that stuff for a couple days and my kidney's were aching fierce.
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The original jack3d.
"I really might be dying"
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Anapolon
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Yohimbe/Yohimbine for me too. It is the only one that makes me feel odd to bad any time I take it. Shame cause it works better than Ephedrine for me.
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dnp
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dnp
This.
I really don't understand why people take DNP - I mean, if you can't get ripped from diet, cardio, T3, clen, GH, or ephedrine, then you've got a serious problem.
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This.
I really don't understand why people take DNP - I mean, if you can't get ripped from diet, cardio, T3, clen, GH, or ephedrine, then you've got a serious problem.
maybe because DNP is cheaper, faster and less harmful (unless youre completely retarded) than diet, cardio, t3, clen, gh or ephedrine
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DMAA
Ephedrine
Arginine or any nitric oxide booster will kill you slowly
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DMAA
Ephedrine
Arginine or any nitric oxide booster will kill you slowly
How does arginine slowly kill you?
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My supplemental health
insurance will probably kill me. .
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I am going with DNP also.
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Dnp. It's kills me when I'm on it but fuck man it works
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How does arginine slowly kill you?
Flooding your body with Peroxynitrate.
The not so pleasant side off effect of Arginine that is conveniently never mentioned in the promotional material of all these stupid NO supplements. Sure its effects are slow, but its probably the most indirectly toxic supplement out there.
Peroxynitrite generation represents a crucial pathogenic mechanism in conditions such as stroke, myocardial infarction, chronic heart failure, diabetes, circulatory shock, chronic inflammatory diseases, cancer, and neurodegenerative disorders
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Cocaine. Best pre workout supplement there is but the old ticker races pretty quickly.
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Flooding your body with Peroxynitrate.
The not so pleasant side off effect of Arginine that is conveniently never mentioned in the promotional material of all these stupid NO supplements. Sure its effects are slow, but its probably the most indirectly toxic supplement out there.
Peroxynitrite generation represents a crucial pathogenic mechanism in conditions such as stroke, myocardial infarction, chronic heart failure, diabetes, circulatory shock, chronic inflammatory diseases, cancer, and neurodegenerative disorders
That's pretty interesting, know of any studies? Id like to read more
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Not a huge amount to hand, but there is tons of studies out there, read up about iNOS and eNOS as well. I will look for some studies and post them here. I believe Arginine, AAKG, Citrulline, Ornithine-alpha keto glutarate and any other NO booster should be avoided. I think Citrulline is the worst out of the lot, being the most effective at boosting NO. I think it is better to stick with things that boost natural NO half life, like Vitamin C for example.
NO has emerged as a fundamental signaling device regulating virtually every critical cellular function, as well as a potent mediator of cellular damage in a wide range of conditions. Recent evidence indicates that most of the cytotoxicity attributed to NO is rather due to peroxynitrite, produced from the diffusion-controlled reaction between NO and another free radical, the superoxide anion. Peroxynitrite interacts with lipids, DNA, and proteins via direct oxidative reactions or via indirect, radical-mediated mechanisms
http://www.ncbi.nlm.nih.gov/pubmed/17237348 (http://www.ncbi.nlm.nih.gov/pubmed/17237348)
http://www.jbc.org/content/288/37/26464.abstract (http://www.jbc.org/content/288/37/26464.abstract)
http://www.enzim.hu/~lbarna/articles/17667957.pdf (http://www.enzim.hu/~lbarna/articles/17667957.pdf)
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Not a huge amount to hand, but there is tons of studies out there, read up about iNOS and eNOS as well. I will look for some studies and post them here. I believe Arginine, AAKG, Citrulline, Ornithine-alpha keto glutarate and any other NO booster should be avoided. I think Citrulline is the worst out of the lot, being the most effective at boosting NO. I think it is better to stick with things that boost natural NO half life, like Vitamin C for example.
NO has emerged as a fundamental signaling device regulating virtually every critical cellular function, as well as a potent mediator of cellular damage in a wide range of conditions. Recent evidence indicates that most of the cytotoxicity attributed to NO is rather due to peroxynitrite, produced from the diffusion-controlled reaction between NO and another free radical, the superoxide anion. Peroxynitrite interacts with lipids, DNA, and proteins via direct oxidative reactions or via indirect, radical-mediated mechanisms
http://www.ncbi.nlm.nih.gov/pubmed/17237348 (http://www.ncbi.nlm.nih.gov/pubmed/17237348)
http://www.jbc.org/content/288/37/26464.abstract (http://www.jbc.org/content/288/37/26464.abstract)
http://www.enzim.hu/~lbarna/articles/17667957.pdf (http://www.enzim.hu/~lbarna/articles/17667957.pdf)
This is really graduate level stuff but from what I'm as to understand is no can oxidize cells casuarina damage and death? Also seems to mix with free radicals in the body leading to complications? I'm i reading this right?
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This is really graduate level stuff but from what I'm as to understand is no can oxidize cells casuarina damage and death? Also seems to mix with free radicals in the body leading to complications? I'm i reading this right?
generally yes. NO is not the problem itself as is it is a free radical with modest negative effects, but it combines with another free radical superoxide to create a powerful oxidant in the form of peroxynitrite.
While the body does need some radicals in the body, generally you dont want to be boosting the amount of free radicals and you definitely don't want to be boosting oxidants, especially very harmful ones.
NO has positive effects at health levels, by keeping blood vessels dilated and smooth so things like arterial plaques (cholesterol) do not form. But the more is better mentality does not apply.
Fr example there was a studies where they prescribed arginine for people with heart disease and endothelial dysfunction (blood vessel lining does not work well, plaques, cholesterol, inflammation etc), as it was believed that by boosting NO, the NO would reverse the damage, initially the arginine helped due to the increased NO, however long term the patients suffered other issues and their endothelial function was still poor, possibly due to long term elevated peroxynitrite.
Supplement companies are selective in telling you what people want to hear and forgetting about the downsides. Beta-Alanine is another supplement with potentially Neurotoxic effects.
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Yohimbine, ECA, Original Jack3d and Clen
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Cocaine. Best pre workout supplement there is but the old ticker races pretty quickly.
costanza, a man with taste for the finer things in life....fuck havent snorted or done any drugs since my ex got pregnant 7years ago..not that i did it often but benching full withamphetamine or coce was great
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costanza, a man with taste for the finer things in life....fuck havent snorted or done any drugs since my ex got pregnant 7years ago..not that i did it often but benching full withamphetamine or coce was great
I haven't done anything for a while either, but I still recall blasting my last couple of bumps before a workout instead of partying, best lifting session ever.
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Hard ten nights
Spiked with a drug in Viagra
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The original jack3d.
"I really might be dying"
That stuff killed erections
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Pgcl makes me feel im dying, using it now to get rid of christmas gristle before I start on the gear again
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Purple Haze made me feel strange.
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generally yes. NO is not the problem itself as is it is a free radical with modest negative effects, but it combines with another free radical superoxide to create a powerful oxidant in the form of peroxynitrite.
While the body does need some radicals in the body, generally you dont want to be boosting the amount of free radicals and you definitely don't want to be boosting oxidants, especially very harmful ones.
NO has positive effects at health levels, by keeping blood vessels dilated and smooth so things like arterial plaques (cholesterol) do not form. But the more is better mentality does not apply.
Fr example there was a studies where they prescribed arginine for people with heart disease and endothelial dysfunction (blood vessel lining does not work well, plaques, cholesterol, inflammation etc), as it was believed that by boosting NO, the NO would reverse the damage, initially the arginine helped due to the increased NO, however long term the patients suffered other issues and their endothelial function was still poor, possibly due to long term elevated peroxynitrite.
Supplement companies are selective in telling you what people want to hear and forgetting about the downsides. Beta-Alanine is another supplement with potentially Neurotoxic effects.
Thank you for this info. I supplement with arginine and beta alinine regularly. Not outside of the recommended dosages. I may eliminate this after reading more on the potential negatives
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Original formula white flood. Felt like I was haddnen taken MDMA through an iv
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HMB... it felt too much like Deca. ;D
Seriously, for me it is Yohimbe and/or Ephedrine
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I'm also sensitive to ephedrine but not as bad as yohimbe :-X
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Thank you for this info. I supplement with arginine and beta alinine regularly. Not outside of the recommended dosages. I may eliminate this after reading more on the potential negatives
No problem, glad it was useful. There are other things that can help boost natural NO production such as citrus fruits (no grapefruit jokes please :-), 70% plus cocoa dark chocolate, alcohol free red wine, pycnogenol.
These work on different mechanisms to dumping a huge amount of a precursor in there. In theory the potential for peroxynitrite production should be much less.
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No problem, glad it was useful. There are other things that can help boost natural NO production such as citrus fruits (no grapefruit jokes please :-), 70% plus cocoa dark chocolate, alcohol free red wine, pycnogenol.
These work on different mechanisms to dumping a huge amount of a precursor in there. In theory the potential for peroxynitrite production should be much less.
Wow great posts "Lord Homos." :D
I usually am up on this stuff but this was news to me, I'll be cutting back as well on my pre workout NO supps. I will however up my Dbol dose to offset any potential catabolism.
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Wow great posts "Lord Homos." :D
I usually am up on this stuff but this was news to me, I'll be cutting back as well on my pre workout NO supps. I will however up my Dbol dose to offset any potential catabolism.
Please, I prefer Lord Humous or Hummus depending on your spelling preference. Strangely enough steroids seem to have some good effects on endothelial function. If you are taking gear NO supplements are waste of time anyway.
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The Gakic, Leukic, and Creakic stack was pretty vicious.