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Getbig Main Boards => Gossip & Opinions => Topic started by: falco on February 14, 2019, 06:55:06 AM

Title: Joe Rogan - David Sinclair, the anti-aging guru
Post by: falco on February 14, 2019, 06:55:06 AM
Very interesting interview where Sinclair discloses what he is currently using to remain young:



Metformin, NMN, diet, fasting, exercise, sauna/cold showers...
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: IroNat on February 14, 2019, 06:59:09 AM
Can you tell us what time  this is mentioned so we don't have to watch the whole vid?
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: Dokey111 on February 14, 2019, 07:00:09 AM
Can you tell us what time  this is mentioned so we don't have to watch the whole fucking vid?

fxd
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: falco on February 14, 2019, 07:55:15 AM
It evens adresses themes like the use of branched chain amino acids and TRT.
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: falco on February 14, 2019, 07:58:09 AM
Can you tell us what time  this is mentioned so we don't have to watch the whole vid?

Phone your valentine telling her you won't be making it tonight because you will be watching the Joe Rogan experience 1234#.
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: Hypertrophy on February 14, 2019, 08:58:27 AM
Sinclair pushes resveratrol as the anti-aging magic bullet. The jury is still out on it- but Sinclair has made a lot of money with companies that are involved in its manufacture. BTW he is only 49 years old. When he hits 69 let's see what he looks like. So many quacks in the anti-aging field because people will believe anything if they think it will keep them young. And quacks can be professors at Harvard.

Ill save you a fortune in pills: just exercise regularly and moderately, sleep 8 or so hours a night, don't smoke, take recreational drugs, drink to excess, or have a high stress life and make sure to get outside more..
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: tres_taco_combo on February 14, 2019, 09:08:18 AM
lots of sleep
fasting
solid clean diet
exercise
avoid stress
use sunscreen
cold showers/sauna/hot yoga
maintain a good sex life
limited booze intake

all can be done without the use of drugs -
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: davej1963 on February 14, 2019, 09:19:22 AM
Sinclair pushes resveratrol as the anti-aging magic bullet. The jury is still out on it- but Sinclair has made a lot of money with companies that are involved in its manufacture. BTW he is only 49 years old. When he hits 69 let's see what he looks like. So many quacks in the anti-aging field because people will believe anything if they think it will keep them young. And quacks can be professors at Harvard.

Ill save you a fortune in pills: just exercise regularly and moderately, sleep 8 or so hours a night, don't smoke, take recreational drugs, drink to excess, or have a high stress life and make sure to get outside more..

He's 49 now, but looks 35. So in 20 years he'll look about 50 so he's probably onto something.
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: njflex on February 14, 2019, 09:47:56 AM
lots of sleep
fasting
solid clean diet
exercise
avoid stress
use sunscreen
cold showers/sauna/hot yoga
maintain a good sex life
limited booze intake

all can be done without the use of drugs -
DITTO...i follow this pretty much to a t.....my sex life has vastly improved since my divorce ;D
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: Hypertrophy on February 14, 2019, 10:13:29 AM
He's 49 now, but looks 35. So in 20 years he'll look about 50 so he's probably onto something.

Aging is non-linear. It happens in 10 year cycles.
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: _bruce_ on February 14, 2019, 02:02:47 PM
Just stay level headed and work out.
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: Dave D on February 14, 2019, 02:38:21 PM
He's 49 now, but looks 35. So in 20 years he'll look about 50 so he's probably onto something.

He doesn't look 35. And theres no guarantee what he will look like in 20 years, he could age in dog years.

He looks good for his age.
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: ratherbebig on February 14, 2019, 03:15:01 PM
complete moron.

one minute into the show and he's talking about results in mice.

apparantely he is a mouse.

Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: IRON CROSS on February 14, 2019, 04:31:07 PM
Can you tell us what time  this is mentioned so we don't have to watch the whole vid?

Go to YouTube D.Sinclair ,more interesting staff  is there .He 1 smart Aussie.
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: Anna Recksiek on February 14, 2019, 09:20:16 PM
You can’t really go by looks. I’m older and all fucked up but still look pretty good
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: IRON CROSS on February 14, 2019, 10:30:26 PM
Sinclair pushes resveratrol as the anti-aging magic bullet. The jury is still out on it- but Sinclair has made a lot of money with companies that are involved in its manufacture. BTW he is only 49 years old. When he hits 69 let's see what he looks like. So many quacks in the anti-aging field because people will believe anything if they think it will keep them young. And quacks can be professors at Harvard.

Ill save you a fortune in pills: just exercise regularly and moderately, sleep 8 or so hours a night, don't smoke, take recreational drugs, drink to excess, or have a high stress life and make sure to get outside more..


U need other staff with Resveratrol to work.
It's cheap , HGH is far more costly  ;)
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: AbrahamG on February 14, 2019, 11:09:32 PM
You can’t really go by looks. I’m older and all fucked up but still look pretty good

Do you like it in the ass?
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: galain on February 14, 2019, 11:48:26 PM
The other thing he said quite often was low protein/less amino acids. Matches what a lot of other anti-aging people are saying about keeping IGF levels low - seems to be a lot better for the heart.
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: falco on February 15, 2019, 12:57:58 AM
I believe his metformin intake is too high, taking into account he is not a diabetic. I am willing to try 500mg a day, if it doesn't upset my stomach.
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: IRON CROSS on February 15, 2019, 01:40:52 AM
I believe his metformin intake is too high, taking into account he is not a diabetic. I am willing to try 500mg a day, if it doesn't upset my stomach.

Do U take Nicotominade Riboside & Niacin too ?, unfortunately there is only 4-5 guys like D.Sinclair  around :-\
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: ratherbebig on February 15, 2019, 05:35:21 AM
Do U take Nicotominade Riboside & Niacin too ?, unfortunately there is only 4-5 guys like D.Sinclair  around :-\

what happened to the rest of them? did they die young?
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: Griffith on February 15, 2019, 05:41:58 AM
The other thing he said quite often was low protein/less amino acids. Matches what a lot of other anti-aging people are saying about keeping IGF levels low - seems to be a lot better for the heart.

IGF increases when HGH goes up, doesn't it?

Wouldn't an increase in IGF be a good thing?
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: usmcdevildoc on February 15, 2019, 08:12:28 AM
Just stay level headed and work out.

Dude looks like a dwarf and probably suffers from micropenis. He looks his age.
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: falco on February 15, 2019, 08:28:07 AM
Regarding fasting:



Rhonda Patrick (from minute 12:30) has very interesting views about fasting.
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: MAXX on February 15, 2019, 08:54:58 AM
iv'e seen younger looking 50 year olds

advice is sound but common knowlage by now
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: IRON CROSS on February 15, 2019, 10:07:45 PM
what happened to the rest of them? did they die young?

consult vince how to survive to 77  ;)
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: galain on February 16, 2019, 02:11:04 AM
IGF increases when HGH goes up, doesn't it?

Wouldn't an increase in IGF be a good thing?

Here's a link to a mouse trial. I didn't have much time to look extensively but it seems to be a theme in this community.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074016/ (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074016/)
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: ratherbebig on February 16, 2019, 09:57:57 AM
i wonder how many shitty supplements theyve tried to sell over the years based on great results with mice.
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: Humble Narcissist on February 16, 2019, 01:23:32 PM
There is no such thing as anti ageing.  You can keep muscle by working out, stay lean by calorie restriction and protect your skin by not getting too much sun but you are still going to break down in your old age and die about the same time as anyone else.
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: Humble Narcissist on February 16, 2019, 01:24:54 PM
consult vince how to survive to 77  ;)
No one can afford the supination machine so we can't use his secret.
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: Disgusted on February 16, 2019, 01:38:00 PM
IGF increases when HGH goes up, doesn't it?

Wouldn't an increase in IGF be a good thing?

No
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: MAXX on February 18, 2019, 10:31:28 AM
There is no such thing as anti ageing.  You can keep muscle by working out, stay lean by calorie restriction and protect your skin by not getting too much sun but you are still going to break down in your old age and die about the same time as anyone else.
well

fasting and low calories in general is supposed to slow down cell degeneration(which is aging)

but none of us here wants to be small and worthless
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: Humble Narcissist on February 18, 2019, 11:16:41 AM
well

fasting and lowories in general is supposed to slow down cell degeneration(which is aging)

but none of us here wants to be small and worthless
As I stated in an earlier post, calorie restriction has been proven to keep mice alive a lot longer and probably works in humans as well.  For it to work for humans it seems the daily caloric limit is about 1,800 calories which would make most of us skinny and scrawny weaklings.  The high profile scientist who actually used this diet and wrote a book about it died at age 79 from ALS.  His name was Roy Walford and the book was called the 120 Year Diet.

https://en.wikipedia.org/wiki/Roy_Walford

Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: ProudVirgin69 on February 18, 2019, 11:21:55 AM
IGF increases when HGH goes up, doesn't it?

Wouldn't an increase in IGF be a good thing?

High IGF levels are desirable for maximal muscle mass but not for longevity
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: IRON CROSS on February 18, 2019, 11:30:18 AM
well

fasting and lowories in general is supposed to slow down cell degeneration(which is aging)

but none of us here wants to be small and worthless



Exept mr. Safety Fat who is fat big & worthless  ;)
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: tres_taco_combo on February 18, 2019, 01:58:33 PM
well

fasting and low calories in general is supposed to slow down cell degeneration(which is aging)

but none of us here wants to be small and worthless

ive been doing lots of fasting (and yes i complete)

totally worth it -

there are several methods of fasting

for anti the aging - research shows you want to do the 20-30 hour fast

Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: Pray_4_War on February 18, 2019, 02:10:34 PM
Ill save you a fortune in pills: just exercise regularly and moderately, sleep 8 or so hours a night, don't smoke, take recreational drugs, drink to excess, or have a high stress life and make sure to get outside more..

I've got every one of these covered...........except my life is very high stress. 
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: Griffith on February 18, 2019, 11:03:21 PM
High IGF levels are desirable for maximal muscle mass but not for longevity

Though IGF also helps protect brain neurons.
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: falco on February 19, 2019, 08:56:58 AM
English is not my forte, but from what i could summarize:

- Either by caloric restriction or by fast everyday, reduce caloric intake
- Avoid carbs and do low protein
- Take 500mg of resveratrol everyday (morning)
- Take 1 gram of NMN (nicotinamide mononucleotide) (morning)
- Take 1 gram of metformin at night
- Avoid red meat
- Avoid iron supplements
- Moderate exercise
- Testosterone and BCCA's reduce lifespan.
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: Griffith on February 19, 2019, 09:43:54 AM
English is not my forte, but from what i could summarize:

- Either by caloric restriction or by fast everyday, reduce caloric intake
- Avoid carbs and do low protein
- Take 500mg of resveratrol everyday (morning)
- Take 1 gram of NMN (nicotinamide mononucleotide) (morning)
- Take 1 gram of metformin at night
- Avoid red meat
- Avoid iron supplements
- Moderate exercise
- Testosterone and BCCA's reduce lifespan.

Though I would think quality of life is more important than total lifespan.
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: The Italian Lifter on February 19, 2019, 01:11:55 PM
As I stated in an earlier post, calorie restriction has been proven to keep mice alive a lot longer and probably works in humans as well.  For it to work for humans it seems the daily caloric limit is about 1,800 calories which would make most of us skinny and scrawny weaklings.  The high profile scientist who actually used this diet and wrote a book about it died at age 79 from ALS.  His name was Roy Walford and the book was called the 120 Year Diet.

https://en.wikipedia.org/wiki/Roy_Walford



Don't want to sound like a smartass but the guy lived like a monk and died 79?
I would choose the way of my grandpa and dad who smoked, fucked like honey badgers, eat like bears and still out lived him by 5 to 8 years.
 ;D
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: Humble Narcissist on February 19, 2019, 01:18:29 PM
Don't want to sound like a smartass but the guy live like a monk and died 79?
I would choose the way of my grandpa and dad who smoked, fucked like honey badgers, eat like bears and still out lived him by 5 to 8 years.
 ;D
Exactly, that was my point that this guy restricted his calories to half and was a skinny scrawny twink and still died at 79 of a debilitating disease.  There is no anti aging diet, drug or lifestyle to keep you alive any longer than anyone else for any real length of time.
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: IRON CROSS on February 19, 2019, 01:47:59 PM
Exactly, that was my point that this guy restricted his calories to half and was a skinny scrawny twink and still died at 79 of a debilitating disease.  There is no anti aging diet, drug or lifestyle to keep you alive any longer than anyone else for any real length of time.


People of Okinawa contradict that  ;)
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: Humble Narcissist on February 20, 2019, 03:26:25 AM

People of Okinawa contradict that  ;)
No they don't.  Life expectancy is only 83 which is a few years longer than western countries.  If you want to live on rice and sprouts everyday go for it.
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: The Italian Lifter on February 20, 2019, 04:12:33 AM
No they don't.  Life expectancy is only 83 which is a few years longer than western countries.  If you want to live on rice and sprouts everyday go for it.

Exactly, a part from smoking and drugs which I'm not interested in, I want to live a full life.
Also you can eat so many good and also healthy things and not live like a monk from Tibet
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: Tha Grim Lifter on February 20, 2019, 04:30:03 AM
Best way to look younger supplements aside

Stay Lean
Resistance training obviously
Some higher intensity cardio sport, I started doing outrigging and now Surf Skiing after I competed in BBing a few times and I looked far younger than I was and still do.
Obviously no alcohol, rec drugs, smoking, prescription drugs

I disagree with his iron supplements statement, that's great until your levels are low from the training I've done.
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: IroNat on February 20, 2019, 04:39:34 AM
Your life expectancy is genetically detemined.

There is little you can do to change it.  The human being however wants to believe he can control this.

Everyone's DNA is different though so just because your father died at 45 doesn't mean you will too.

Extremely poor lifestyle habits can shorten your life just like a deadly car accident.  If you are exposed to plutonium or inhale asbestos you will die sooner.

Life is a crapshoot.
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: Humble Narcissist on February 20, 2019, 04:54:59 AM
Your life expectancy is genetically detemined.

There is little you can do to change it.  The human being however wants to believe he can control this.

Everyone's DNA is different though so just because your father died at 45 doesn't mean you will too.

Extremely poor lifestyle habits can shorten your life just like a deadly car accident.  If you are exposed to plutonium or inhale asbestos you will die sooner.

Life is a crapshoot.
If life expectancy is determined by genetics but you can't use parents as a guide then how do you know it's genetically determined? :-\
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: IroNat on February 20, 2019, 05:01:10 AM
If life expectancy is determined by genetics but you can't use parents as a guide then how do you know it's genetically determined? :-\

However all those genes are mixed up is how it works out.

Every child of two parents comes out different.

I'm a bro-scientist with a degree in bro-ology.
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: BUCK Murdock on February 20, 2019, 06:24:25 AM
Apparently results in mice don't necessarily translate to results in humans. Resveratrol and NMN supplements have not shown good results in human trials.
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: IroNat on February 20, 2019, 08:40:47 AM
Apparently results in mice don't necessarily translate to results in humans. Resveratrol and NMN supplements have not shown good results in human trials.

Except for a noticeable cheese craving.
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: Humble Narcissist on February 20, 2019, 11:24:18 AM
However all those genes are mixed up is how it works out.

Every child of two parents comes out different.

I'm a bro-scientist with a degree in bro-ology.
I'm not shitting on you but the medical community that makes these claims.  If a person lives a long time they say it's genetics even if his siblings, parents and distant relatives died early.  How is a person supposed to know if they have the longevity gene pre-death? 
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: IroNat on February 20, 2019, 12:44:43 PM
I'm not shitting on you but the medical community that makes these claims.  If a person lives a long time they say it's genetics even if his siblings, parents and distant relatives died early.  How is a person supposed to know if they have the longevity gene pre-death? 

Life is a crapshoot.

Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: Griffith on February 20, 2019, 01:13:44 PM
There's also epigenetics, the study of how our actions can alter or influence our genetics or gene expression during our lifetime.

So for instance, the lifestyle of a parent could apparently even affect the starting genetics of the children they have.

Even our state of mind could affect our gene expression.
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: Humble Narcissist on February 20, 2019, 01:15:18 PM
There's also epigenetics, the study of how our actions can alter or influence our genetics or gene expression during our lifetime.

So for instance, the lifestyle of a parent could apparently even effect the starting genetics of the children they have.

Even our state of mind could effect our gene expression.
Even our state of mind could effect our gene expression.  ***Winner, winner, chicken dinner!***
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: Earl1972 on February 20, 2019, 06:18:37 PM
his forehead doesn't move too much, might have used botox

E
Title: Re: Joe Rogan - David Sinclair, the anti-aging guru
Post by: falco on February 21, 2019, 12:43:32 AM
English is not my forte, but from what i could summarize:

- Either by caloric restriction or by fast everyday, reduce caloric intake
- Avoid carbs and do low protein
- Take 500mg of resveratrol everyday (morning)
- Take 1 gram of NMN (nicotinamide mononucleotide) (morning)
- Take 1 gram of metformin at night
- Avoid red meat
- Avoid iron supplements
- Moderate exercise
- Testosterone and BCCA's reduce lifespan.

Forgot daily sauna / cold showers.