I would say yes to that. A lot depends on your overall health and conditioning. But yes, generally speaking I’d say you need to look out for your cardiovascular health including cholesterol and heart, kidneys, liver, prostate, testicular health etc if you are on anything over hrt dosages over 45 even if you felt you have been healthy up to that point. The variables would be dosage, type of aas, your overall health, and what condition you are in along with history of use. I would go out on a limb to say that some might actually improve health and quality of living if they adjusted their test/ estrogen ratio to that of a healthy 25 yo male. Playing it safe is wise. Your health is priceless.