well i will say this, i been on letro 2 weeks, both nips are wayyyyyy down from being puffed out however on my left pec there is either adipose tissue cause i do have slight fat in my love handles so its either fat there or gyno, it would suck if it is, it makes my pec look a little strange but i have more cutting to do before i can tell for sure.. but the letro and nolva i had did shrink the puffy nipples.