Hey freakfest could you elaborate on this? Does tren decrease production of prolactin-inhibiting hormone? Is tren considered a female hormone because I have heard of female estrogens causing this effect?
I do not really know for sure, to be honest. It seems that much of trens reputed effect on increasing prolactin levels comes more from underground heresay than from scientific fact. In fact, the medical literature, although scant on this topic, would suggest that the
opposite is true (see articles below).
Androgens in almost all cases lower prolactin levels and higher than normal levels of estrogen raise prolactin.
Big-O (
much respect) took some degree of blame for promoting this concept on the old getbig board, whether directly or indirectly. Several years ago he posted studies in relation to a certain trenbolone compound raising prolactin levels. The compound was Synovex plus. The high estradiol concentration in Synovex was the chief mechanism of action of this. He posted the full study and outlined why there was a lack of dopaminergic binding to the lactotrophs in the anterior pituitary region, thus resulting in raised prolactin levels. As he summarized, "the stalk was cut and excess prolactin was dumped into the portal system." He later reiterated that he did not believe that tren as we all know it should have a prolactin-raising effect.
I hope you find the following articles to be of interest:
Effects of anabolic implants of oestradiol alone or in combination with trenbolone acetate on the ultrastructure of mammary glands in female lambs regarding their interference in prolactin secretion.
Blanco A, Moya L, Flores R, Aguera E, Monterde JG.
Department of Comparative Anatomy and Pathological Anatomy, Veterinary Faculty, University of Cordoba, Spain.
The side-effects of anabolic steroid implants on mammary gland ultrastructure were evaluated in female lambs treated with oestradiol (n = 10) and with oestradiol plus trenbolone acetate (n = 10). Ten non-implanted lambs were used as controls. Apart from the ultrastructural study of the mammary gland, an assessment of the prolactin pituitary cell population was carried out by immunological methods. Our results showed that oestrogenic implants exert stimulating effects on mammary gland development, both by activating the synthesis process at mammary gland cell levels and by increasing prolactin pituitary production. Nevertheless, there was no evidence of secretory products in the lumen of the gland.
Implants containing trenbolone acetate counteracted the mammary stimulus of oestrogens showing ultrastructural images of cell autolysis and necrosis.Growth hormone, insulin, prolactin and total thyroxine in the plasma of sheep implanted with the anabolic steroid trenbolone acetate alone or with oestradiol.Donaldson IA, Hart IC, Heitzman RJ.
The mode of action of the anabolic steroid trenbolone acetate (19-norandrost-4,9,11-trien-3-one-17-acetate) was studied through the endogenous hormonal response of castrated male sheep to subcutaneous implantation of 140 mg of trenbolone acetate and 20 mg of oestradiol both separately and in combination. Radioimmunoassay of delta-4,9,11-trienic steroids and oestradiol-17 beta in plasma confirmed that simultaneous administration of trenbolone acetate with oestradiol led to a significantly greater persistence of oestradiol-17 beta residues in plasma (P less than 0.05) than with implantation of oestradiol alone. Oestradiol treatment increased concentrations of growth hormone and insulin (P less than 0.05; P less than 0.001 respectively) in plasma samples collected weekly.
Trenbolone acetate by itself had no significant effect and the oestrogenic response was blocked on the simultaneous implantation of trenbolone acetate and oestradiol (despite higher plasma levels of oestradiol-17 beta with this treatment). Plasma total thyroxine was markedly depressed to 45 per cent of its basal level by trenbolone acetate, alone or with oestradiol (P less than 0.001) and depressed to 80 per cent of basal by oestradiol treatment alone (P less than 0.001). Plasma prolactin was unaltered by the above treatments.
