Author Topic: New Research  (Read 797 times)

smaul

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New Research
« on: April 29, 2007, 11:39:34 PM »
How long till this hits the shops?  Looks pretty good, actually activates genes responsible for fat loss!



US scientists have devised a drug that can switch on a gene to burn body fat, offering hope of an exercise pill.
Mice given the drug burned off fat, even when they did not exercise, and were resistant to weight gain despite a high-fat diet.

The ultimate use would be to treat people at risk of obesity-related diseases like diabetes, rather than offer a "no-work six-pack" pill.

The Salk Institute team presented their work at Experimental Biology 2007.

  Although this might become an 'exercise pill', it is unlikely to provide all the other benefits of real physical exercise

UK expert Dr Fredrik Karpe

The drug mimics normal fat and chemically triggers a gene switch called PPAR-delta.

Turning on this switch activates the same fat-burning process that occurs during exercise.

Lead researcher Dr Ronald Evans believes the same will occur in humans.

Human trials

UK expert Dr Fredrik Karpe, from the Oxford Centre for Diabetes, Endocrinology and Metabolism, is hoping to test this in the near future.

Commenting on the work, he said: "There has never been a method to 'medically' switch on fat burning before.

"The finding that PPAR-delta co-ordinates this process, not only by switching on fat burning, but also to rebuild the muscle in a way making it more fit for fat burning, is of major interest, not least as a completely novel approach for the treatment of the metabolic derangements accompanying obesity."

But he cautioned; "Although this might become an 'exercise pill', it is unlikely to provide all the other benefits of real physical exercise."


http://news.bbc.co.uk/2/hi/health/6599013.stm
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Tapeworm

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Re: New Research
« Reply #1 on: April 30, 2007, 04:46:44 AM »

The drug mimics normal fat and chemically triggers a gene switch called PPAR-delta.

Turning on this switch activates the same fat-burning process that occurs during exercise.


I've never heard of PPAR-delta, but I assume there's a reason it isn't "switched on" all the time, namely other chemical signals.  Will this pill make it more difficult to lose fat (or easier to gain it back) once the person stops taking it?  Hard to believe anything comes for free.

It is interesting stuff though.  I'll let some other guinnea pigs try it out for a few years before I'd consider it.