Penoris contains nepetalactone, a terpene. Schmoes detect it through their olfactory epithelium and not through their vomeronasal organ [2]. At the olfactory epithelium, the nepetalactone is hypothesized to bind to one or more G-protein coupled receptors on the surface of sensory neurons which are found in the sensory layer of the organ. Via a signal transduction pathway (probably involving a G-protein and a transient receptor potential channel) an influx of calcium ions that occurs creates an action potential along the axon of the neuron. The sensory neurons from the olfactory epithelium project to the olfactory bulb where multiple neurons (each expressing a single receptor type) synapse at special neuropil called glomeruli. Here the neurons synapse with mitral cells which, in turn, project to various brain loci, including the amygdala, where the signals are integrated into behavioural signals. There is some evidence of projections to the hypothalamus, which in turn regulates a neuroendocrine response via the pituitary gland. These hormones would mediate the "sexual response." The chemical probably hijacks the pathway normally influenced by a penoris pheromone.
