another clown trying to sound like he knows something, when i fact he's never used the stuff at all.
keep reading and spouting off about something you know nothing about.
dnp if used properly is an awesome fat burner. i wouldnt use it again just due to the discomfort associated with its use.
it makes you so uncomfortable, that just the act of walking seems difficult. drains you of any/all energy you have.
that being said, i'd rather go thru 4-6 weeks more diet/ cardio than run this stuff again, and i have used it on 4 different occasions, so my opinion isnt based on one shot, or what i read like the idiot who posted above me.
Read this moron........
2,4-DINITROPHENOL
Please Note: The main sources of information for this fact sheet are EPA's Integrated Risk Information System (IRIS), which contains information on the oral chronic toxicity of 2,4-dinitrophenol and the RfD, and the National Research Council's Drinking Water and Health. Other secondary sources include the Hazardous Substances Data Bank (HSDB), a database of summaries of peer-reviewed literature, and the Registry of Toxic Effects of Chemical Substances (RTECS), a database of toxic effects that are not peer reviewed.
Environmental/Occupational Exposure
* Little information is available on environmental exposure to 2,4-dinitrophenol. The available data suggest that exposure to 2,4-dinitrophenol occurs primarily from pesticide runoff to water. (1)
Assessing Personal Exposure
* No data were located concerning personal exposure to 2,4-dinitrophenol.
Health Hazard Information
Acute Effects:
* Acute (short-term) oral exposure to high levels of 2,4-dinitrophenol in humans has resulted in nausea, vomiting, sweating, dizziness, headache, loss of weight, and other symptoms. The lethal oral dose is reported to be 14 to 43 mg/kg. (2)
* 2,4-Dinitrophenol is considered to have high acute toxicity, based on short-term animal tests such as the LD50 tests in rats and mice. (3)
Chronic Effects (Noncancer):
* Chronic (long-term) oral exposure to 2,4-dinitrophenol in humans and animals has resulted in the formation of cataracts and skin lesions and has caused effects on the bone marrow, central nervous system, and cardiovascular system. (2)
* The RfD for 2,4-dinitrophenol is 0.002 mg/kg/d based on cataract formation in humans. (4)
* EPA has low confidence in the study on which the RfD was based since this study only describes anecdotal data; low confidence in the database since the supporting database is meager; and, consequently, low confidence in the RfD. (4)
* EPA has determined that there are inadequate data for the establishment of an RfC for 2,4-dinitrophenol. (4)
* EPA's Office of Air Quality Planning and Standards, for a hazard ranking under Section 112 (g) of the Clean Air Act Amendments, has evaluated 2,4-dinitrophenol for chronic toxicity and has given it a composite score of 30 (scores range from 1 to 100, with 100 being the most toxic). These scores are nonlinear and are the product of two ratings: a rating based on the minimal-effect-dose and a rating based on the type of effect. (1)
* EPA's Office of Air Quality Planning and Standards, for a hazard ranking under Section 112 (g) of the Clean Air Act Amendments, considers 2,4-dinitrophenol to be a "high concern" pollutant based on severe chronic toxicity. (1)
Reproductive/Developmental Effects:
* No information is available on the reproductive or developmental effects of 2,4-dinitrophenol in humans.
* The available animal studies reported fetal growth inhibition, but no birth defects in the offspring of animals fed 2,4-dinitrophenol. (5)
Cancer Risk:
* No information is available on the carcinogenic effects of 2,4-dinitrophenol in humans.
* One oral study in mice reported no tumor formation after 6 months exposure, but another study reported that 2,4-dinitrophenol did not promote tumor development in mice. (5)
* EPA has not classified 2,4-dinitrophenol for potential carcinogenicity. (1)
Physical Properties
* The chemical formula for 2,4-dinitrophenol is C6H4N2O5 and the molecular weight is 184.11 g/mol. (6)
* The vapor pressure for 2,4-dinitrophenol is 1.42 H 10-7 mm Hg at 25 EC, and its log octanol/water partition coefficient is 1.91. (7)
* 2,4-Dinitrophenol exists as yellowish crystals, is slightly soluble in water, and is volatile with steam. (6)
* The odor threshold for 2,4-dinitrophenol is not available.
Uses
* 2,4-Dinitrophenol is used in the manufacture of dyes and wood preservatives and as a pesticide. (6)
* 2,4-Dinitrophenol is also used as an indicator for the detection of potassium and ammonium ions. (6)
Health Data from Oral Exposure
Concentration (mg/kg/d)
Health numbersa
Regulatory, advisory numbersb
Reference
100.0
_
_
_
_
10.0
* LD50 (cats) (75 mg/kg)
* LD50 (mice) (45 mg/kg)
* LD50 (rats) (30 mg/kg)
3
3
3
_
_
_
_
1.0
* LOAELc (humans) (2 mg/kg/d)
4
_
_
_
_
0.1
_
_
_
_
0.01
_
_
_
_
0.001
* EPA RfD (0.002 mg/kg/d)
4
LD50 (Lethal Dose50)CA calculated dose of a chemical in water to which exposure for a specific length of time is expected to cause death in 50% of a defined experimental animal population.
LOAELCLowest-observed-adverse-effect level.
RfDCReference dose.
a Health numbers are toxicological numbers from animal testing or risk assessment values developed by EPA.
b Regulatory numbers are values that have been incorporated in Government regulations, while advisory numbers are nonregulatory values provided by the Government or other groups as advice.
c The LOAEL is from the critical study used as the basis for the EPA RfD.
References
