Author Topic: Letrozole  (Read 2361 times)

sherdogger

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Letrozole
« on: December 27, 2007, 12:56:39 PM »
so does this really work for gyno? this has proably been discussed before on here but im new. Will it help with pre-existing gyno? like will it get rid of pre-existing gyno completely?

Luv2Hurt

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Re: Letrozole
« Reply #1 on: December 27, 2007, 01:01:53 PM »
No it will not get rid of true prexisting gyno.

sherdogger

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Re: Letrozole
« Reply #2 on: December 27, 2007, 01:11:19 PM »
even if the gyno isnt that bad? like just in the nipple area? not like big man boobs just puffy nipples?

busyB

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Re: Letrozole
« Reply #3 on: December 27, 2007, 01:36:01 PM »
even if the gyno isnt that bad? like just in the nipple area? not like big man boobs just puffy nipples?

There was a post on this not too long ago. Probably do a search...

I used 2.5 mg of letro from a research company, for about two weeks and got rid of the gyno I had. It will never get rid of it completely until you remove the gland. Meaning, it could flare up again once you go back on cycle

jtsunami

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Re: Letrozole
« Reply #4 on: December 27, 2007, 02:39:08 PM »
The endo I goto says the anti-E's and ai's really do not do a good job at taking care of the gyno or taking away the pain gyno causes.
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Re: Letrozole
« Reply #5 on: December 27, 2007, 04:15:58 PM »
The endo I goto says the anti-E's and ai's really do not do a good job at taking care of the gyno or taking away the pain gyno causes.

Unfortunately most endocrinologists (as well as most doctors) don't know anything about non standard drugs.  They learn what they need to in med school and what their normal practice requires them to know, but that is about it.  That said, anti-estrogens and aromatase inhibitors will not remove growth, however, what they will do is atrophy the mammary glands but limiting the available estrogens.  This is similar to cutting off the LH in the males HPTA loop, the testes will atrophy.  The result will be that the swelling of the glands will go down and the adipose will stop accumulating and will decrease locally to a degree.  The hard tissue of the lactiferous ducts and alveoli that becomes overdeveloped in gynecomastia will never go away without removal, but AEs and AIs will halt their growth in most cases, which will stop the soreness that results. Basically if you have had gyno for years, taking medication will not help you, but if you recently started the growth you can quickly reduce the swelling and buildup, which may make it seem small enough that it isn't noticed.  If you have gyno combined with lactation then you also have a problem with progesterone and/or prolactin levels which is caused and treated in a different fashion.

busyB

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Re: Letrozole
« Reply #6 on: December 27, 2007, 04:55:42 PM »
Unfortunately most endocrinologists (as well as most doctors) don't know anything about non standard drugs.  They learn what they need to in med school and what their normal practice requires them to know, but that is about it.  That said, anti-estrogens and aromatase inhibitors will not remove growth, however, what they will do is atrophy the mammary glands but limiting the available estrogens.  This is similar to cutting off the LH in the males HPTA loop, the testes will atrophy.  The result will be that the swelling of the glands will go down and the adipose will stop accumulating and will decrease locally to a degree.  The hard tissue of the lactiferous ducts and alveoli that becomes overdeveloped in gynecomastia will never go away without removal, but AEs and AIs will halt their growth in most cases, which will stop the soreness that results. Basically if you have had gyno for years, taking medication will not help you, but if you recently started the growth you can quickly reduce the swelling and buildup, which may make it seem small enough that it isn't noticed.  If you have gyno combined with lactation then you also have a problem with progesterone and/or prolactin levels which is caused and treated in a different fashion.

Yeah, this is what I meant to say  ::)

As for prolactin, what do you suggest? Dosinex? I never had lactation but all the other symtoms as I ran deca, then tren with test for 20 weeks.


Beener

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Re: Letrozole
« Reply #7 on: December 29, 2007, 06:28:57 PM »
The endo I goto says the anti-E's and ai's really do not do a good job at taking care of the gyno or taking away the pain gyno causes.

Yeah I wondered how effective letro was, so out of curiosity i stopped takin it...it was cool for a few days then bam my left nipple started hurtin again, like lotsa pain, so i jumped back on the letro and it went a way. Lesson learned, letro is good. 

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Re: Letrozole
« Reply #8 on: December 30, 2007, 08:54:33 AM »
Yeah I wondered how effective letro was, so out of curiosity i stopped takin it...it was cool for a few days then bam my left nipple started hurtin again, like lotsa pain, so i jumped back on the letro and it went a way. Lesson learned, letro is good. 

Yes once you start on letro, or adex you need to run it all the way through cycle.

Luv2Hurt

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Re: Letrozole
« Reply #9 on: December 30, 2007, 12:36:13 PM »
Yes once you start on letro, or adex you need to run it all the way through cycle.

I totally agree.  All this stopping and starting it is ridiculous.  It does not work well that way.  letro takes if I remember correctly about 7-14 to build up enough and become active.  This spot addministration for a few days does not work.

RDW

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Re: Letrozole
« Reply #10 on: December 30, 2007, 01:04:36 PM »
I totally agree.  All this stopping and starting it is ridiculous.  It does not work well that way.  letro takes if I remember correctly about 7-14 to build up enough and become active.  This spot addministration for a few days does not work.

The half life is 2 days and a good plasma level is built up in about 5-7 days.  Anastrozle is a 3 day HL and 7-10 days for good levels.  Aromasin is faster acting (it works in different manner than letro/anastrozle) the half life is 27 hours and effects can often be felt the same day while the plasma levels peak in about 3-5 days.

trab

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Re: Letrozole
« Reply #11 on: December 30, 2007, 02:38:09 PM »
I totally agree.  All this stopping and starting it is ridiculous.  It does not work well that way.  letro takes if I remember correctly about 7-14 to build up enough and become active.  This spot addministration for a few days does not work.

That it is a Major invitation to bad estrogen side effects.. (Start & stop)

Did you guys see that post on Brown nipple discharge? (Muscle 19?) Overload says hes also heard of the same deal
from some others w/ Letro rebound. Not funny.

Luv2Hurt

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Re: Letrozole
« Reply #12 on: December 30, 2007, 02:46:23 PM »
The half life is 2 days and a good plasma level is built up in about 5-7 days.  Anastrozle is a 3 day HL and 7-10 days for good levels.  Aromasin is faster acting (it works in different manner than letro/anastrozle) the half life is 27 hours and effects can often be felt the same day while the plasma levels peak in about 3-5 days.

Thanks man thought it was something close to a week or so.

That it is a Major invitation to bad estrogen side effects.. (Start & stop)

Did you guys see that post on Brown nipple discharge? (Muscle 19?) Overload says hes also heard of the same deal
from some others w/ Letro rebound. Not funny.

Yeah I think so too.

muscle19

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Re: Letrozole
« Reply #13 on: December 30, 2007, 04:30:23 PM »
The stoping and going isn't funny at all! I switched from letro to adex and I use 1mg everyday, and my nipples have stopped hurting and see going down, the discharge is gone from taking this on a regular bases! By stopping and starting letro, my body became flooded with estrogen, not cool!
muscle

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Re: Letrozole
« Reply #14 on: December 30, 2007, 05:31:32 PM »
Yes once you start on letro, or adex you need to run it all the way through cycle.

Yeah don't worry it was a one time thing. I wouldn't start and stop it randomly. Fuck I make sure i stay on the shit, dont want my gyno worsening! Just a bad judgement call one time, but it really made me see how effective the letro is, so i was sharing.

Cheers