How does milk thistle actually work?

[ToxicAvenger]

or is it an old wives tale?

[noodrin]

interesting subject

My father has fatty liver due to Massive alcohol and According to father both AST ALT are pretty bad.
So he prescribed Glutathione, but he run out and didnt visit dr since September.

Recently I bought Liv.52 and samarin 140. father took 6tab Liv.52 and 280mg samarin ed.
I will post bloodwork result when he run out 200T samarin

BTW demecal is awesome for who don't like doctors.

[Vet]

http://www.ahrq.gov/clinic/epcsums/milktsum.htm
http://www.ahrq.gov/clinic/tp/milkttp.htm
Theres quite a bit of debate about milk thistle depending on who you ask. 

[freakfestMD]

interesting subject

My father has fatty liver due to Massive alcohol and According to father both AST ALT are pretty bad.
So he prescribed Glutathione, but he run out and didnt visit dr since September.

Reduced glutathione is marketed under the trade name Tationil.  It can be taken at 200mg IM every 4 weeks throughout a cucle for liver protection.

There is evidence that the compound in milk thistle can interfere with the androgen receptor, and so it may not be ideal for someone on a cycle of AAS.

[Slintowin4424]

Milk thistle is believed to have protective effects on the liver and improve its function. It is typically used to treat liver cirrhosis, chronic hepatitis (liver inflammation), and gallbladder disorders. Treatment claims also include:

Lowering cholesterol levels
Reducing insulin resistance in people with type 2 diabetes who also have cirrhosis
Reducing the growth of cancer cells in breast, cervical, and prostate cancers

[ToxicAvenger]

thanx for all the info guys..

take home lesson..

it cant hurt after a cycle..soo why not

[Van_Bilderass]

A study you may not have seen

Med Pregl. 2003;56 Suppl 1:79-83. Links
[Hepatoprotective effects of silymarin in androgenic-anabolic steroid-induced liver damage]
[Article in Serbian]

INTRODUCTION: The use and abuse of anabolic-androgenic steroids (AAS) commonly induces liver damage. MATERIAL AND METHODS: The study included 40 male Wistar rats, divided into 4 groups of 10 rats each. Animals in the first experimental group (M), were subjected to progressive systematic forced swimming test, 5 days a week, during 8 weeks. Animals in this group were treated with AAS methandienone [Dianabol], 2 mg/kg BW/day, per os, before swimming, 5 d/w for 8 weeks. After swimming, animals were given three times more food than the laboratory animals of the same age and kind. Animals in the second group (M+S), were subjected to progressive forced swimming test, 5 d/w 8 weeks. Animals in this group were treated with methandienone equally as the experimental group M and received the same amount of food. Apart from that, they received silymarin 20 mg/kg BW/day. Animals in the third group (K), represented the control group, which was neither subjected to swimming test, nor treated with methandienone or silymarin. Animals in this group received the same amount of food as animals in groups M and M+S. Animals in the fourth group ©, also represented a control. This group was not exercised nor treated, and animals received a standard amount of food for laboratory animals of this kind and age. Quantitative analysis of obtained hemataxylin-eosin, periodic acid shift and enzymohistochemical preparations was processed using Digital Image Analysis System: Microimage 3.0. RESULTS: It was established that processes in the nuclei of animals in groups M and K were significantly more intensive (p<0.001) in relation to groups M+S and C. The investigation of glycogen showed significantly higher density in the cells of groups M and M+S in comparison to groups K and C. Also, there was a significant difference between groups M+S and M. Density of enzyme activity of glutamate dehydrogenase in hepatocytes of animals in the group M+S was significantly higher in relation to the remaining three groups. A statistically significant difference was not found in enzyme activity of succinate dehydrogenase and lactate dehydrogenase. DISCUSSION: In cell nuclei of animals in the experimental group M, in the absence of silymarin effect, methandienone causes damages which induce regenerative processes and in this way increase high intensity activity. Silymarin significantly increases the glycogen density in hepatocytes. Increased activities of GDH are attributed to cell vitality. CONCLUSION: The present results show hepatoprotective effects of silymarin in androgenic-anabolic steroid induced liver damage.

PMID: 15510919

I don't think it hurts gains any either, there was some study pointing to it maybe inhibiting the AR in the prostate. In any case I'm sure the potential AR inhibiting effect is overridden completely by the string anabolic effect of the steroids.

[noodrin]

interesting subject

My father has fatty liver due to Massive alcohol and According to father both AST ALT are pretty bad.
So he prescribed Glutathione, but he run out and didnt visit dr since September.

Recently I bought Liv.52 and samarin 140. father took 6tab Liv.52 and 280mg samarin ed.
I will post bloodwork result when he run out 200T samarin

BTW demecal is awesome for who don't like doctors.

Best things for liver seems get rid of any liver stress. After above regime still bloodwork show no improvement. father doesnt say clearly but

GGT above 500
AST and/or ALT 70~80

time to stop alcohol abuse