smokepole... grain fed meats would NOT be organic. grain is what livestock are fed with on factory farms. same with chickens, and fish too. wild game feeds off of the land..off of grass..cla is more abundant in organic beef and eggs than in factory beef and eggs. just as omega-3's and omega-6's are found in organic meat, while they are not found in factory fed meat.
CLA is natural.
you might argue that there are no benefits(your argument would be invalid, however, because it DOES work), but your argument that its HARMFUL is just plain stupid.
linoleic acid is an omega 6 polyunsaturated fat.
what do you think the conjugation does to it?
if you think conjugating an omega-6 makes it a trans fat, well, okay; but realize that trans fats are not deemed unhealthy when they are in the form of a conjugated fat.
look it up.
First off i can tell you lack the power to deduce. You said "
lol. cla is not a trans fat... cla is an omega-6 fatty acid..its naturally found in grass fed organic beef and eggs. "
so, first off it is a trans fat, so you where proven wrong already.
Secondly you said GRASS FED ORGANIC beef and eggs, its found in any grass fed animal, and organic is not grass fed as the title of organic means raised without pesticides, hormones, etc..
http://en.wikipedia.org/wiki/Organic_food#Legal_definitionso there goes that whole sentence.
"CLA is natural", SO?
"you might argue that there are no benefits(your argument would be invalid, however, because it DOES work), but your argument that its HARMFUL is just plain stupid. "
you have any evidence for your claims? i do. When adults argue intelligently they provide evidence for their arguments, specifically factual ones not anecdotal or emotional ones like your making.
"
your argument that its HARMFUL is just plain stupid. "
THIS IS BRAND NEW TOO. ON TOP OF THE PREVIOUS STUDIES.JUST READ WHAT I BOLDED FOR YOU, AS I KNOW YOUR ALLERGIC TO TRUTH.
J Nutr. 2008 Mar;138(3):455-61. Links
Trans-10, cis-12 conjugated linoleic acid antagonizes ligand-dependent PPARgamma activity in primary cultures of human adipocytes.Kennedy A, Chung S, LaPoint K, Fabiyi O, McIntosh MK.
Department of Nutrition, University of North Carolina, Greensboro, NC 27402-6170, USA.
We previously demonstrated that trans-10, cis-12 (10,12) conjugated linoleic acid (CLA) causes human adipocyte delipidation, insulin resistance, and inflammation in part by attenuating PPARgamma target gene expression. We hypothesized that CLA antagonizes the activity of PPARgamma in an isomer-specific manner. 10,12 CLA, but not cis-9, trans-11 (9,11) CLA, suppressed ligand-stimulated activation of a peroxisome proliferator response element-luciferase reporter. This decreased activation of PPARgamma by 10,12 CLA was accompanied by an increase in PPARgamma and extracellular signal-related kinase (ERK)1/2 phosphorylation, followed by decreased PPARgamma protein levels. To investigate if 10,12 CLA-mediated delipidation was preventable with a PPARgamma ligand (BRL), cultures were treated for 1 wk with 10,12 CLA or 10,12 CLA + BRL and adipogenic gene and protein expression, glucose uptake, and triglyceride (TG) were measured. BRL cosupplementation completely prevented 10,12 CLA suppression of adipocyte fatty acid-binding protein, lipoprotein lipase, and perilipin mRNA levels without preventing reductions in PPARgamma or insulin-dependent glucose transporter 4 (GLUT4) expression, glucose uptake, or TG. Lastly, we investigated the impact of CLA withdrawal in the absence or presence of BRL for 2 wk. CLA withdrawal did not rescue CLA-mediated reductions in adipogenic gene and protein expression. In contrast, BRL supplementation for 2 wk following CLA withdrawal rescued mRNA levels of PPARgamma target genes. However, the levels of PPARgamma and GLUT4 protein and TG were only partially rescued by BRL. Collectively, we demonstrate for the first time, to our knowledge, that 10,12 CLA antagonizes ligand-dependent PPARgamma activity, possibly via PPARgamma phosphorylation by ERK.
MORE PROOF
Appl Physiol Nutr Metab. 2007 Jun;32(3):372-82.Links
Conjugated linoleic acid increases skeletal muscle ceramide content and decreases insulin sensitivity in overweight, non-diabetic humans.Thrush AB, Chabowski A, Heigenhauser GJ, McBride BW, Or-Rashid M, Dyck DJ.
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, N1G 2W1, Canada. athrush@uoguelph.ca
The effect of conjugated linoleic acid (CLA), a popular weight-loss supplement, on insulin sensitivity in humans is controversial and has not been extensively studied. To date no studies have examined the effects of CLA supplementation on human skeletal muscle metabolism or lipid content. It is also unknown whether CLA accumulates in human skeletal muscle with supplementation. In the present study, 9 overweight, non-diabetic individuals received 4 g/d of mixed CLA isomers in the form of 1 g supplements, for 12 weeks. CLA isomers significantly increased in both plasma and skeletal muscle following supplementation. Skeletal muscle ceramide content was also significantly increased, although there was no consistent change in muscle diacylglycerol or triacylglycerol content. Insulin sensitivity was significantly decreased (p<or=0.05) following CLA supplementation, with a significant increase in glucose and insulin area under the curve during an oral glucose tolerance test (p<or=0.005). The protein content of PPARalpha, for which CLA is a potent ligand, was unchanged following supplementation. Accordingly, there was no change in markers of muscle oxidative capacity.
In conclusion, mixed-isomer CLA supplementation in overweight non-diabetic humans results in the accumulation of CLA and ceramide in skeletal muscle, and decreases insulin sensitivity.MORE
Crit Rev Food Sci Nutr. 2006;46(6):479-88. Links
Conjugated linoleic acid intake in humans: a systematic review focusing on its effect on body composition, glucose, and lipid metabolism.Salas-Salvadó J, Márquez-Sandoval F, Bulló M.
Departament de Bioquímica i Biotecnologia, Facultat de Medicina i Ciències de la Salut de Reus, Spain. jss@fmcs.urv.es
Studies performed on different species show that the consumption of conjugated linoleic acid (CLA) leads to a loss of fat and total body weight, reduces the plasma concentrations of total and LDL cholesterol, and has an antiinflammatory effect. This article reviews the clinical trials on human beings that evaluate how mixtures of CLA isomers administered as supplements or CLA-enriched products can affect total body weight, body composition, plasma lipid profile, glycemia, insulinemia, insulin sensitivity, lipid oxidation, and inflammation. After analyzing the few studies published to date in reduced samples of healthy humans or patients with overweight, obesity, metabolic syndrome, or diabetes, we deduce that there is not enough evidence to show that conjugated linoleic acid has an effect on weight and body composition in humans.
However, some of these studies have observed that the administration of various CLA isomers has adverse effects on lipid profile (it decreases HDL cholesterol concentration and increases Lp(a) circulating levels), glucose metabolism (glycemia, insulinemia or insulin sensitivity), lipid oxidation, inflammation, or endothelial function. Therefore, long-term randomized clinical trials, controlled with placebo, need to be made in large samples of patients to evaluate the efficacy and safety of CLA isomers before its indiscriminate use in human beings can be recommended.Atheroscler Suppl. 2006 May;7(2):37-9. Epub 2006 May 18. Links
Trans fatty acids and insulin resistance.Risérus U.
Clinical Nutrition and Metabolism, Uppsala University, Faculty of Medicine, Sweden. ulf.riserus@pubcare.uu.se
Since trans fatty acids (TFA) might interfere with cell membrane functions, there are reasons to believe that high TFA intakes could affect insulin sensitivity and consequently diabetes risk. It is possible that low amounts of TFA consumed during long time-periods might be clinically relevant. Data from controlled intervention studies investigating the effects of TFA on insulin sensitivity are reviewed. The results show no significant effect of TFA on insulin sensitivity in lean healthy subjects.
However, there is some evidence that TFA could impair insulin sensitivity compared to unsaturated fat in insulin resistant or diabetic individuals. This is especially true for conjugated TFA, i.e. conjugated linoleic acid (CLA), which clearly impairs insulin sensitivity. In fact, the effect of CLA on insulin action is the most dramatic adverse effect described for a dietary fatty acid. The inconsistent effect of TFA as a group might partly be due to methodological limitations (e.g. few studies, short duration or small sample size) and differences between studies in design, type and amount of TFA used. Large controlled trials have been required to demonstrate adverse effects of saturated fat on insulin sensitivity, and similar efforts will probably be needed to clarify the effect of TFA on insulin sensitivity.
Arterioscler Thromb Vasc Biol. 2006 Feb;26(2):307-12. Epub 2005 Dec 8. Links
Conjugated linoleic acid impairs endothelial function.Taylor JS, Williams SR, Rhys R, James P, Frenneaux MP.
Morriston Hospital, Swansea, UK. jswt@totalise.co.uk
OBJECTIVE: To determine the effect of dietary supplementation with conjugated linoleic acid (CLA) on body mass index (BMI), body fat distribution, endothelial function, and markers of cardiovascular risk. METHODS AND RESULTS: Forty healthy volunteers with BMI >27 kg/m2 were randomized to receive a CLA isomeric mixture or olive oil in a 12-week double-blind study. Subcutaneous body fat and abdominal/hepatic fat content were assessed using skin-fold thicknesses and computed tomography scanning, respectively. Endothelial function was assessed by brachial artery flow-mediated dilatation (FMD). Plasma isoprostanes were measured as an index of oxidative stress. CLA supplementation did not result in a significant change in BMI index or total body fat. There was a significant decrease in limb (-7.8 mm, P<0.001), but not torso skin-fold thicknesses or abdominal or liver fat content. Brachial artery FMD declined (-1.3%, P=0.013), and plasma F2-isoprostanes increased (+91 pg/mL, P=0.042).
CONCLUSIONS: A CLA isomeric mixture had at most modest effects on adiposity and worsened endothelial function. On the basis of these results, the use of the isomeric mixture of CLA as an aid to weight loss cannot be recommended.ANYWAY THERE is more but you get the point, the supp is shit with obvious consequences shown in human studies that are well done. This supp can hinder fat loss and does the opposite of fish oil, reduce insulin sensitivity, endothelial function, may have adverse effects on heart health.
THERE IS NO GOOD REASON TO TAKE THIS SUPP AND MANY THAT PROVE IT IS HARMFUL. IT IS SHIT IN A BOTTLE.
NOW, you could be an ass and continue to make retarded arguments or try to discuss this intelligently. Prove im wrong
