Author Topic: pm question answered - receptor downgrade  (Read 13594 times)

The Coach

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Re: pm question answered - receptor downgrade
« Reply #25 on: April 09, 2008, 09:17:36 PM »
'androgen receptor'

you know what that is, right?

if testosterone was insulin and androgen receptors were muscle cells the receptopr downgrade would be like insulin resistance

get it now?

That wasn't my question..........the specific words were "Receptor Downgrade" I punch it in and nothing remotely comes up.

candidizzle

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Re: pm question answered - receptor downgrade
« Reply #26 on: April 09, 2008, 09:19:24 PM »
That wasn't my question..........the specific words were "Receptor Downgrade" I punch it in and nothing remotely comes up.
that WAS your question ..what, are you afraid of being percieved as someone who learned something from 'candidizzzle' ??

hahaha
 ;D

Arnold jr

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Re: pm question answered - receptor downgrade
« Reply #27 on: April 09, 2008, 09:19:56 PM »
"Receptor Downgrade" the second most misused misunderstood concept in bodybuilding...first place goes to the term "Over Training."

The Coach

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Re: pm question answered - receptor downgrade
« Reply #28 on: April 09, 2008, 09:26:36 PM »
that WAS your question ..what, are you afraid of being percieved as someone who learned something from 'candidizzzle' ??

hahaha
 ;D


From a friend of mines site who I work with frequently




http://www.johnberardi.com/articles/hormones/androgen.htm

candidizzle

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Re: pm question answered - receptor downgrade
« Reply #29 on: April 09, 2008, 09:30:29 PM »

From a friend of mines site who I work with frequently




http://www.johnberardi.com/articles/hormones/androgen.htm
just skimmed through it.   what was your point? you dont think i understand what androgens and androgen receptors are?




AJ, what are your thoughts on the subject? to what extent do you think downgrade exists and occurs?

Hurricane Beef !

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Re: pm question answered
« Reply #30 on: April 09, 2008, 09:44:59 PM »
naposim terapia
anabol british dispenary
you wont find russian any more only methyl but some like it

the main 2 and the only 2 i recomend are naposim and anabol by british disp,,,those 2 are 20-30 lb within first 4 weeks gh15 approved,,again must be legit because ip like to do the pentagons ,,

no i do not approve danabol as of now days no need to ask

What about the use of DBol on training days only as recommended by some.

Th eBeef

Arnold jr

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Re: pm question answered - receptor downgrade
« Reply #31 on: April 09, 2008, 09:58:45 PM »

AJ, what are your thoughts on the subject? to what extent do you think downgrade exists and occurs?
I've been fairly blunt on the subject many times on here before and I believe it is one of the biggest excuses people make in regards to their lack of growth and success as a bodybuilder.

Like GH15 said, so many guys out there use UG garbage and this is a large part of what leads to the myth of receptors being downgraded, flooded, etc. Here's why.

Any guy who buys hormones from a UG supplier, assuming it is real...most of the time it is real...however, most of the time it's severally underdosed and more often then that every bottle, every vile and amp is underdosed test. It may say deca, tren, etc but in actuality is is underdosed test. So the guy does the cycle, he grows...anyone will grow off a small minute amount of hormones the first time...a lot no, but it happens. But if you want to be big, really big, make continued gains the crap has to be real. For many guys when the initial growth stops they immediately say something about receptors...why not, it sounds good right? The truth of the matter, their gear was junk...that's all the problem there is.

Part of the problem with most guys understanding this is they view their receptors like a bank. For example, the drugs go in, they pile up in the receptors and sit there until the job is done...eventually the receptor runs out of room. This is a rough example but all I can think of at the moment. Obviously this is ridiculous, it's no differant then saying that every time you drink a whey protein shake the whey's amino's mound up inside the muscle bellies until their is no room left and that you need to stop taking in protein until they can refresh...this makes no sense so why would the other?

Again, I realize this is a very rough example, and there are a lot of "technical" things that could be added in to give it sound backing. However, when it comes to that sort of thing, sometimes simple ways of explaining do a better job.

Vince B

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Re: pm question answered - receptor downgrade
« Reply #32 on: April 09, 2008, 10:12:38 PM »
Hardly a scientific way to approach using hormones. What makes you know what anyone was taking and how pure those substances were? Seems to me there is way too much speculating and hardly any real knowledge here. This is exactly what I expected. The blind are leading and advising the ignorant.

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Re: pm question answered - receptor downgrade
« Reply #33 on: April 09, 2008, 10:16:59 PM »
Dr Bernardi is not an expert in receptor research. He merely interprets some research for his clients which don't appear to be bodybuilders. The University of Western Ontario doesn't sound like a premier university for exercise science research. I doubt many on Getbig can comprehend the cited article.

Wonder why the young doctor abandoned his bodybuilding career? He claims a bench of 430 pounds in competition.

Arnold jr

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Re: pm question answered - receptor downgrade
« Reply #34 on: April 09, 2008, 10:31:02 PM »
Hardly a scientific way to approach using hormones. What makes you know what anyone was taking and how pure those substances were? Seems to me there is way too much speculating and hardly any real knowledge here. This is exactly what I expected. The blind are leading and advising the ignorant.
I was simply trying to be as "simple" as I could. Most people do not respond to understanding "actuality" they need to be spoon fed. Not because they are incapable of understanding, but rather it is the only way they'll take it.

As far as knowing how "pure the substances are" well, it's common and accepted knowledge that most UG gear is "UG" "Underdosed Garbage." Anyone who's used both "UG" & "HG" knows this to be true.

Vince B

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Re: pm question answered - receptor downgrade
« Reply #35 on: April 09, 2008, 10:39:27 PM »
Well, surely the test for drugs is a science lab and not how someone places in a contest. If the guy wins he must be on the right stuff? I am sorry, you might be right but that logic is lame.

jr

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Re: pm question answered - receptor downgrade
« Reply #36 on: April 10, 2008, 12:35:21 AM »
'androgen receptor'

you know what that is, right?

if testosterone was insulin and androgen receptors were muscle cells the receptopr downgrade would be like insulin resistance

get it now?


The term you idiots should be looking for is "Receptor Downregulation".

Van_Bilderass

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Re: pm question answered - receptor downgrade
« Reply #37 on: April 10, 2008, 04:24:09 AM »
Hardly a scientific way to approach using hormones. What makes you know what anyone was taking and how pure those substances were? Seems to me there is way too much speculating and hardly any real knowledge here. This is exactly what I expected. The blind are leading and advising the ignorant.

Do you not know that the mechanism of how many drugs work in modern medicine is not fully understood? Pick up a PDR and read it. Side effects are not known either which is why you often see drugs withdrawn after many years of use. If you are waiting for some type of definitive data on drugs you are going to be waiting a long time.




Bob's own words humiliate him. I merely point out the obvious. He has achieved very little re bodybuilding titles.

Now, the point was what are your qualifications regarding exercise science? Do you hold a degree in science? I doubt it. Anyone who believes crap about extraterrestrials is not what I call informed, educated or enlightened. You are expert in nothing at all. Don't come here crapping on about receptors when you don't have the vocabulary to do so.


Do YOU have a degree in exercise science? Has that stopped you from training and trying different protocols? Has it stopped you from having strong opinions on the subject?

FullROM

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Re: pm question answered - receptor downgrade
« Reply #38 on: April 10, 2008, 04:28:00 AM »
I don't know much about steroids but if Growth hormone is so good why waste money on test, dbol etc

The Coach

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Re: pm question answered - receptor downgrade
« Reply #39 on: April 10, 2008, 07:05:45 AM »
.

Wonder why the young doctor abandoned his bodybuilding career? He claims a bench of 430 pounds in competition.


Yes, as a matter of fact I do...........he was smart!

Stavios

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Re: pm question answered - receptor downgrade
« Reply #40 on: April 10, 2008, 07:58:44 AM »
"Receptor Downgrade" the second most misused misunderstood concept in bodybuilding...first place goes to the term "Over Training."

I had the proof that it isn't a myth last year

peroni

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Re: pm question answered - receptor downgrade
« Reply #41 on: April 10, 2008, 08:05:48 AM »
Dr Bernardi is not an expert in receptor research. He merely interprets some research for his clients which don't appear to be bodybuilders. The University of Western Ontario doesn't sound like a premier university for exercise science research. I doubt many on Getbig can comprehend the cited article.

Wonder why the young doctor abandoned his bodybuilding career? He claims a bench of 430 pounds in competition.

In the pic you posted, the good doctor has bigger biceps than thighs. :o

Vince B

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Re: pm question answered - receptor downgrade
« Reply #42 on: April 10, 2008, 08:53:35 AM »

Do YOU have a degree in exercise science? Has that stopped you from training and trying different protocols? Has it stopped you from having strong opinions on the subject?

I've taken an exercise science course during my masters degree. However, I don't claim to be an exercise scientist. Not knowing about those drugs has definitely stopped me from using those extreme protocols. I haven't popped a pill since the mid 1970s.

Arnold jr

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Re: pm question answered - receptor downgrade
« Reply #43 on: April 10, 2008, 09:08:08 AM »
I had the proof that it isn't a myth last year
?

Stavios

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Re: pm question answered - receptor downgrade
« Reply #44 on: April 10, 2008, 09:11:00 AM »
?

there was a huge guy at my gym who has been juicing for 10 years +, he wasn't making any gains anymore.

he took a year off the juice, lost a shitload of weight, got back on with the same dosages and he ended up 20 pounds heavier than he ever was after only 3 months back on


candidizzle

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Re: pm question answered - receptor downgrade
« Reply #45 on: April 10, 2008, 09:13:58 AM »
there was a huge #### at my gym who has been juicing for 10 years +, he wasn't making any gains anymore.

he took a year off the juice, lost a shitload of weight, got back on with the same dosages and he ended up 20 pounds heavier than he ever was after only 3 months back on


what if he would have dropped the ijectables, switched to orals, ran some hcg and some clomid for two weeks, then hopped back on the injectables...   

 ;D ;D ;D ;D

Stavios

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Re: pm question answered - receptor downgrade
« Reply #46 on: April 10, 2008, 09:16:25 AM »
off cycle means OFF everything for us normal people  ;D

candidizzle

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Re: pm question answered - receptor downgrade
« Reply #47 on: April 10, 2008, 09:17:09 AM »
yeah...but, WHAT IF..??  lol    :D

Overload

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Re: pm question answered - receptor downgrade
« Reply #48 on: April 10, 2008, 09:23:56 AM »
there was a huge #### at my gym who has been juicing for 10 years +, he wasn't making any gains anymore.

he took a year off the juice, lost a shitload of weight, got back on with the same dosages and he ended up 20 pounds heavier than he ever was after only 3 months back on

That isn't exactly "proof"...

Too many factors come into play.

I know guys who have been on for over 5 years and they still make impressive gains every year.

8)

Stavios

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Re: pm question answered - receptor downgrade
« Reply #49 on: April 10, 2008, 09:25:50 AM »
that's a proof for me if the guy didn't change anything in his lifestyle exept stopping the juice and starting again


 8)