Maybe some people feel that synthetic hormones, on the cellular level, don't react exactly the same as your own genetically coded hormones. Very close, but not exactly. It also seems some people start with a light dose of say testosterone, and for a while everything is great..Sex drive is up, muscle mass is up, fat loss. Then after a while, the effects begin to diminish and the sex drive goes down. Between courses of anti-estrogens, HCG, then maybe proscar for hair loss and prostatic enlargment, high doses of test are needed to get the same effect as in the beginning. Soon that dose doesn't work as well, and higher doses are needed. Then more auxilliaries to combat the sides. I don't think HRT has been perfected yet. Look at Stallone. Yeah, his physique looks impressive, but it seems his face is very bloated and distorted from the GH and Test. I'm 45 and I wouldn't do HRT at this point. Maybe in 5 years if there are doctors that really perfect it. For now, I just take supplements that I find increase my own GH and test levels. They definitely work, just not dramatically. Some people in their 40's definitely need it and it helps with their quality of life. I just prefer personally to stimulate my own production rather than replace them.