Alright as everyone knows im a big fan of sesamin and forskolin for fat loss, so i will post some info why.
Dietary sesamin and docosahexaenoic and eicosapentaenoic acids synergistically increase the gene expression of enzymes involved in hepatic peroxisomal fatty acid oxidation in rats.Arachchige PG, Takahashi Y, Ide T.
Laboratory of Nutritional Biochemistry, National Food Research Institute, Tsukuba 305-8642, Japan.
The interaction of sesamin, one of the most abundant lignans in sesame seed, and highly purified docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA) in the form of ethyl ester in affecting hepatic fatty acid oxidation was examined in rats. In the first experiment, 3 groups of rats were fed with purified experimental diets free of n-3 fatty acid ethyl ester and containing 0%, 0.2%, and 0.4% sesamin (1:1 mixture of sesamin and episesamin), and 2 groups of animals were fed with a 2% DHA ethyl ester diet containing either 0% or 0.2% sesamin. In the second trial, 4 groups of rats were fed with either a 0% or a 2% EPA ethyl ester diet containing 0% or 0.2% sesamin. After 15 days of feeding, DHA and EPA ethyl esters added to a sesamin-free diet little affected the activity and messenger RNA (mRNA) levels of various enzymes involved in fatty acid oxidation. Sesamin increased the activity levels of various hepatic enzymes involved in fatty acid oxidation irrespective of the presence or absence of n-3 fatty acid ethyl ester in diets. However, the diet containing sesamin and DHA or EPA ethyl ester in combination increased many of these parameters synergistically. In particular, the peroxisomal palmitoyl-coenzyme A oxidation rate and acyl-coenzyme A oxidase activity level were much higher in rats fed with sesamin and DHA or EPA in combination than in animals fed with a diet free of n-3 fatty acid ethyl ester and containing sesamin. Analyses of mRNA levels revealed that a diet simultaneously containing sesamin and n-3 fatty acid ethyl ester increased the gene expression of various enzymes involved in peroxisomal fatty acid oxidation in a synergistic manner. However, the combination of sesamin and n-3 fatty acid ethyl esters was ineffective in causing a synergistic increase in mRNA levels of enzymes of mitochondrial fatty acid oxidation, microsomal cytochrome P-450 IV A1, and cytosolic liver-type fatty acid-binding protein.
It was concluded that sesamin and DHA or EPA ethyl ester synergistically increased hepatic fatty acid oxidation primarily through up-regulation of the gene expression of peroxisomal fatty acid oxidation enzymes. The results essentially reproduced those observed in our previous study with a diet containing both fish oil and sesamin despite the fact that DHA and EPA ethyl esters were much less effective than fish oil in increasing hepatic fatty acid oxidation.
the short and sweet here is that sesamin does what fish oil does, that is increase fat burning enzymes called PPAR alpha only to a higher degree and also works synergistically with fish oil to do this, win win situation.1: Metabolism. 1999 Oct;48(10):1303-13. Links
Sesamin, a sesame lignan, is a potent inducer of hepatic fatty acid oxidation in the rat.Ashakumary L, Rouyer I, Takahashi Y, Ide T, Fukuda N, Aoyama T, Hashimoto T, Mizugaki M, Sugano M.
Laboratory of Nutrition Biochemistry, National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries, Tsukuba, Japan.
The effects of sesamin, one of the most abundant lignans in sesame seed, on hepatic fatty acid oxidation were examined in rats that were fed experimental diets containing various amounts (0%, 0.1%, 0.2%, and 0.5%) of sesamin (a 1:1 mixture of sesamin and episesamin) for 15 days. Dietary sesamin dose-dependently increased both mitochondrial and peroxisomal palmitoyl-coenzyme A (CoA) oxidation rates. Mitochondrial activity almost doubled in rats on the 0.5% sesamin diet. Peroxisomal activity increased more than 10-fold in rats fed a 0.5% sesamin diet in relation to rats on the sesamin-free diet. Dietary sesamin greatly increased the hepatic activity of fatty acid oxidation enzymes, including carnitine palmitoyltransferase, acyl-CoA dehydrogenase, acyl-CoA oxidase, 3-hydroxyacyl-CoA dehydrogenase, enoyl-CoA hydratase, and 3-ketoacyl-CoA thiolase. Dietary sesamin also increased the activity of 2,4-dienoyl-CoA reductase and delta3,delta2-enoyl-CoA isomerase, enzymes involved in the auxiliary pathway for beta-oxidation of unsaturated fatty acids dose-dependently. Examination of hepatic mRNA levels using specific cDNA probes showed a sesamin-induced increase in the gene expression of mitochondrial and peroxisomal fatty acid oxidation enzymes. Among these various enzymes, peroxisomal acyl-CoA oxidase and bifunctional enzyme gene expression were affected most by dietary sesamin (15- and 50-fold increase by the 0.5% dietary level). Sesamin-induced alterations in the activity and gene expression of carnitine palmitoyltransferase I and acyl-CoA oxidase were in parallel with changes in the mitochondrial and peroxisomal palmitoyl-CoA oxidation rate, respectively.
In contrast, dietary sesamin decreased the hepatic activity and mRNA abundance of fatty acid synthase and pyruvate kinase, the lipogenic enzymes. However, this lignan increased the activity and gene expression of malic enzyme, another lipogenic enzyme. An alteration in hepatic fatty acid metabolism may therefore account for the serum lipid-lowering effect of sesamin in the rat.here we see another good thing sesamin does which is inhibit most lipogenic (fat storing) enzymeshttp://www.bodybuilding.com/fun/beast21.htman article that covers some of the topics, and is worth a read to get the basic gist of it.write-up on forskolin, i was going to post abstracts but this writeup is from a good company which outline its other benefits people should know about, for the record it is working great on my asthma.http://www.thorne.com/media/ColeusMono.pdfthe short and sweet, it increase a second messenger cAMP which is involved in a host of biological activities, one being lipolysis(fat loss), while simultaneously stimulating thyroid secretion, increases TSH from the ant pituatary which increase t3/t4=more fat lossso for the original question i would suggest taking forskolin, fish oil, sesamin, l-tyrosine,rasberry ketones, Ecgc and possibly some items for cortisol reduction since you want to avoid stims. Namely phosphotidylserine and cissus quadrangularis along with 6 grams of daily vitamin c, this would be a nice overall stack.
mild stimulants for the record like low dose caffeine will do you no harm and i would argue are healthy wrt to keeping dopaminergic neurons healthy, ie staving off parkisons and alzheimers. However, i would suggest coffee insted of caffeine as it disrupts sleep architecture less, has potent antioxidants which will help with fat loss and a monoamine oxidase inhibitor (a and b) called beta carboline which will elevate your mood.
hope that helps son.
