recpetor downgrade/oversaturation/diminishing returns

[Van_Bilderass]

Train Natural.

Amen. Not worth the hassle to juice. Just take some Jungle Warfare with Monkey Balls for PCT.

[candidizzle]

wow. i remember trying to read those articles before and they were all mumbo-jumbo to me. now they are somewhat complex but very informative and i understand them ! cool.

thx van

[abc123]

wow. i remember trying to read those articles before and they were all mumbo-jumbo to me. now they are somewhat complex but very informative and i understand them ! cool.

thx van

Will you please summarize the article for those of us that don't have the time to read in detail? 

[local hero]

do you realy need to know,,, why make bodybuilding so complicated?... ronny and dorian were at the max size they could possibly acheive until the next new big drug discovery, theres a limit to how big u can get...

on the subject of receptor downgrade,,, it doesnt exist!.. i'll tell u why in everyday terms...

 u take a 269lb bodybuilder, he's been on for 2 yr straight,, isnt grown like he used to ( see above ) , so he comes off to clean up.... looses size and conditon in the 6 month to a yr off.... comes back on, spends 6 month to get back to where he was, then is back to where he was before..

only thing that will change that body will be more drugs, different drugs ( slin etc ) even more time on etc etc... when youve already got to that stage where the extras are added and your still stalling,, your done, thats your peak size more or less,,, they think its downgrade cos there on 2000mg more than 2 yrs ago and there not gaining...bullshit....

[DIVISION]

I find it very hard to believe that there isn't a limit to the total amount and saturation abilities of androgen receptors.  At some point they all have to be being utilized, which to me seems like it'd be a prime point for the body to say "well, looks like we got enough of this, no need for so many test receptors) and will downregulate the number of receptors. 

I agree.

from wiki

Anabolic steroids such as methandrostenolone bind weakly to this receptor and instead directly affect protein synthesis or glycogenolysis.[51] On the other hand, steroids such as oxandrolone bind tightly to the receptor and act mostly on gene expression.http://en.wikipedia.org/wiki/Anabolic_steroid

(last portion of 'mechanism of action')

^Don't get your AAS knowledge from Wikipedia.

That has to be one of the most ignorant things I've ever seen on here.

Even the generic info from bodybuilding.com is pretty accurate.

Don't give advice to other people if you don't know what you're talking about.

u take a 269lb bodybuilder, he's been on for 2 yr straight,, isnt grown like he used to ( see above ) , so he comes off to clean up.... looses size and conditon in the 6 month to a yr off.... comes back on, spends 6 month to get back to where he was, then is back to where he was before..

only thing that will change that body will be more drugs, different drugs ( slin etc ) even more time on etc etc... when youve already got to that stage where the extras are added and your still stalling,, your done, thats your peak size more or less,,, they think its downgrade cos there on 2000mg more than 2 yrs ago and there not gaining...bullshit....

You're forgetting about the synergistic effect that AAS/GH/IGF-1 have on each other when taken together........or any combination of AAS for that matter.

You didn't take in to account training and diet and sleep patterns.

Many factors go in to optimal growth and I don't see it as a genetic ceiling that only a few ever reach.

There's alot more research that needs to be done before we can come to that conclusion.


DIV

[candidizzle]

^Don't get your AAS knowledge from Wikipedia.

That has to be one of the most ignorant things I've ever seen on here.

Even the generic info from bodybuilding.com is pretty accurate.

Don't give advice to other people if you don't know what you're talking about.
DIV

yeah because the binding affinity an androgen has for the AR is really common knowledge and really something that i SHOULD know, and something that talking about without full knowledge would have any consequence for anyone reading it...  give me a goddamn break

[DIVISION]

yeah because the binding affinity an androgen has for the AR is really common knowledge and really something that i SHOULD know, and something that talking about without full knowledge would have any consequence for anyone reading it...  give me a goddamn break

You don't have enough experience to give any advice, bro.

That's the point people were making.

I'm just voicing it because I'm a Mod.

It's not like people haven't complained about you before.


DIV

[candidizzle]

You don't have enough experience to give any advice, bro.

That's the point people were making.

I'm just voicing it because I'm a Mod.

It's not like people haven't complained about you before.


DIV

dude dont give me that bullshit, i was discussing androgen receptors...

but hey bro

you know

its all good

keep doing your thing BIG MAN

 

[Alex23]

dude dont give me that bullshit, i was discussing androgen receptors...

but hey bro

you know

its all good

keep doing your thing BIG MAN

 

hahaha candidizzle, don't mind the fat emotial "DIVIDED"..

you = young buck with potential. Will make sure you follow through and florish.

him = washed up individual who emotionally rely on his made up internet love stories to stay afloat.

[DIVISION]

hahaha candidizzle, don't mind the fat emotial "DIVIDED"..

you = young buck with potential. Will make sure you follow through and florish.

him = washed up individual who emotionally rely on his made up internet love stories to stay afloat.

.....back to playing internet wars, I see, Alex?

Why would I expect you to disagree with dizzle when you have done much the same thing as he is doing.

Not much intelligence or experience required to load up on anabolics.

Do you know the guy offline, do you anyone from here offline?

I think you spend way too much time assuming things about people you've never met.

Of course, I could just delete everything you post as I have in the past..........but then no one would see what a meathead you are.

You're like a Kovacs without the strength.   


DIV