Anyone who knows anything about real lab work on heavy Androgen users, would realize that it alters cholesterol levels(LDL and HDL) for the worse. This can even be seem with mild doses of Anavar. Take over a gram of test for several years and combine that with heavy beef intake, do you think maybe...just maybe, that might contribute to Plaque in your arteries. Does anyone think that some of your Mr. O competitors may start seeing some heart troubles by their mid to late 40's? Also, the heart has valves which contain Androgen receptors, which has been shown in studies to hypertrophy. This enlarged valve syndrome can cause some serious problems too.