Looking for Help

[newbie2IGFL3]

Hi,

I'm a 31 yr old male. Have done light cycles of test/winstrol/d-bol about 8 yrs ago. I just got my first cycle of IGF-1R3 and IGF-1 Ec (MGF). {I apologize if these arn't the proper terms}  . I'm getting so many conflicting opinions/experiences/advice on how to take this, or if it's even good at all!  Update:

- both have come in powder form, from China
- I've gotten BW to mix with it (is that right? If so, what ratio?)
- told to take MGF post workout - 100 mcgs/day (split between both sides of muscle just trained)
      Long IGF-1 R3 1 hour after -   50 - 100mcgs/day  {are these doses high for a first cycle?}
- how many consecutive days is it safe to take these?
- just did blood tests about three months ago - are they still applicable? If yes, should I request them?

Thank you for all your help.

[4thAD]

PM EMmortal he is the peptide expert! 

[Emmortal]

Ehh well not really a peptide expert I just like to dabble

So a few things first.  There hasn't been a whole lot of positive feedback on MGF, especially the non peg version of it (which only lasts about 7 minutes or so in your system the peg version will last about 17 hours).  I've ran pegMGF several times now, I got instant DOMS in the injection muscles and a severe pump.  I ran the MGF 24 hours prior to working out the muscle group and then ran the LR3-IGF1 post work out.  I've had a lot of good experiences with LR3-IGF1, but can't really quantify my results with pegMGF.  I've read a few guys that say you should run the MGF for a month first, then run the IGF after that for a month, but again this is just someones opinion.

Personally I'd just ditch the MGF and not even  bother with it, but if you were going to run it, I'd probably run it for a month first and then run the IGF.  I haven't run it this way so you might get better results than the way I did it.

LR3-IGF1 should be injected immediately post work out.  A 40mcg dose bi-laterally is probably about as much as you want to use, smaller doses would be preferred in new users (20mcgs).  You won't see a huge amount of effects immediately from it, some leaning out, more vascularity and increased pumps.  The incredible part doesn't happen for about 8-10 months down the road when new muscle cells have matured.

For reconstitution, here's some good info:

Reconstitution.

But just about always you do not have to worry about reconstituting it yourself. All of the manufacturers usually suspend their LR3 in either BA or AA for you.

The calculation:
Distilled white vinegar is supposed to be standardized to ~5% acetic acid, which would make it 850mM. To get it to the recommended 100mM, you'd want 11.76% white vinegar (100mM/850mM = 11.76%). Since it would be almost impossible to draw out 11.76IU's, I round this to 12, which is certainly going to be close to our desired 100mM.

The filtering process:
I use off the shelf grocery store distilled white vinegar. In order to ensure safety, I filter it using .20u whatman filters. Here is the step by step for those that may not be familiar with filtering using whatmans. What you will want to have on hand before starting out is some sterile vials, some .20u whatman filters, some syringes and needles (I use a 10cc syringe, and .23 gauge 1" needles), and some alcohol swabs.

(1) First draw up about 10cc of the distilled white vinegar
(2) screw on the .20u whatman to the 10cc syringe (or whatever size you use)
(3) screw on a .23 gauge needle (or whatever size you decide to use)
(4) take your sterile vial, swab the top with alcohol, insert a needle for venting.
(5) Insert your syringe/whatman/needle apparatus and slowly push the 10cc's into the sterile vial.

Now you have safe vinegar to use for your reconstituting.

ALTERNATE METHOD - Alternately, you could simply mix your water and distilled white vinegar before filtering using about 7.5 parts of water per 1 part of distilled white vinegar. After mixing these together in this ratio, run the mixture through your .20u whatman as above. You will end up with a vial of dilutent this way that has the proper PH for use with your IGF-1.

Reconstituting:

How much water/vinegar you reconstitute with is going to somewhat depend on which LR3 IGF-1 you are using. Igtropin is shipped in 100mcg vials, which I usually reconstitute at 1ml(cc) per 100mcg vial (which will make the 10 mark on your insulin syringe = 10 mcgs). The gropep based IGF-1's are primarily shipped in 1mg vials, and I usually use 5ml for these (which will make the 10 mark on your insulin syringe = 20mcgs).
At any rate, what I do is:

(1) take an alcohol swab and swab the tops of my water, vinegar solution, and IGF-1 vials
(2) take a syringe with a 23 gauge, 1" needle and draw out .12 cc's of vinegar for the 100mcg vials or .60 cc's for the 1mg vials.
(3) next I take this syringe and draw out the water - .88cc's for 100mcg, 4.4cc's for the 1mg.

FOR ALTERNATE METHOD in lieu of steps (2) and (3) - Just draw out the desired amount of dilutent from your pre-mixed vial of
vinegar / water.

(4) next i poke the needle into the LR3 IGF-1 vial and dribble this solution down the side of the vial, avoid any direct spray on the lyophilized powder until all of the dilutent is in the vial
(5) using a gentle swirling motion, I reconstitute the powder.
(6) I stick the vial in the fridge and it is now ready for use.

[Emmortal]

Also, for the most optimum results, you'll want to be on cycle when running IGF.

[tbombz]

On Mgf =

(posts taken from promuscle  http://www.professionalmuscle.com/forums/showthread.php?t=31120&page=2 )

The key factor for androgens stimulated muscle hypertrophy appears to be the satellite cells. Under influence of androgens satellite cells dividing twice faster.

In such situation two factors will play most important role, number of CD34 cells with CXR4 receptor released from bone marrow (can be increased by use of GM-CSF) and space available or not in trained muscles. If no space satellite cells will simply die. Key factor which can provide free space and stimulate proliferation of satellite cells is MGF. b/c  one of very important role of MGF is in modulation of fibrinolitic enzymes in trained muscle.

http://joe.endocrinology-journals.org/cgi/reprint/191/2/349.pdf

I assume that concept about over saturated receptors was brought up to the light with purpose to explain,
some kind of plateau situation when AAS did not works so well as it was before.
Obviously this explanation is not so correct, and some other limiting factors are there.

imo here two main factors, which can make muscle unresponsive to androgen stimulation:

- cells density in that muscle too too high, and muscle architecture cannot change overnight. It need time and modulation of
fibrinolitic enzymes secreted locally is  muscle. Therefore MGF, I would consider as most potent drug for local growth, b/c only MGF can
stimulate  both, proliferation of muscle satellite cells and change muscle architecture by modulating fibrinolitic enzymes system.

Try to inject in large muscle group bilaterally with 400 mcg of PEG MGF EOD for one week.
Any lagging muscle group will respond, with sufficient amount of protein in diet. That, I would consider as a concept
prove of importance of modulation of fibrinolitic enzymes system for changing muscle architecture.

- second limiting factor is amount of satellite cells grafted into the trained muscle. The idea of "no free space no grafting", again points toward importance of MGF. But amount of stem cells released from bone marrow during training plays very importnat role on its own.

All androgens and growth factor can only
act via satellite cells, then obviously more satellite cells presented at that moment better will be response fro drugs.
The use of GM-CSF PWO can increase number of stem cells homed in exactly those muscle which where trained.

During training a lot of very well communicated events happening, with one purpose compensation and recovery of muscles.
It is so well communicated events, different receptors expressed , different growth factors secreted, myostatin suppressed etc.
One example: during training bone marrow releasing CD34 cells, not just any kind of CD34 cells, but those cells,
which released from bone marrow during training expressing CXR4 receptor. Means those cells released from bone marrow,
with one purpose to regenerate muscles, and not any muscles, but exactly those which were trained, because CXR4 receptor is receptor
for SDF-1 (stromal cell derived factor), which expressed during training in in those muscles which were trained.
SDF-1 expressed during training and because of it CD34 cells with CXR4 receptor will get new home exactly in this place.
Why it happen during weight lifting, and not during marathon running, because expression of SDF-1 regulated
by HIF1 hypoxia inducible factor 1, which is in fact is transcription factor for SDF1.

Nerves much more sensitive to hypoxia and they will declare failure much faster then muscles, therefore the use of such drugs like piracetam can be very beneficial with this style of training.

It is one reason, why DC style training works. You can inject 800 mcg MGF and run 30 miles, your muscles will not become bigger.