Dave Meltzer reports on Wrestling Observer Radio and in his latest newsletter (subscription required) that Anderson Silva has informed the UFC that he won't be ready to fight by UFC 95 in London. This leaves the UFC in a really bad position, as they once again have a London show where they have to scramble for a main event, and it's hard to think of anything they can come up with for a show that is scheduled for PPV.
That is the short term story, the long term story is Anderson Silva's status with the UFC. It's very clear to me that this is not a time issue, just a few months ago Anderson wanted to be fighting all the time. It's obvious that Anderson had no interest in fighting guys like Luis Cane or Thales Leites, and he appears to be more interested in boxing training than fighting guys on that level.
What can be done for Anderson Silva at this point? The middleweight division is a mess, none of the potential fights are marketable, and it sounds like he isn't interested in fighting unless the fight is a big fight. There are obviously 185 options all over the world that would be interesting to hardcore fans, but Anderson seems to be only interested in doing big fights.