Anticancer activity in urea.
http://www.ncbi.nlm.nih.gov/pubmed/6851311?ordinalpos=14&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
The effects of urea treatment in combination with curettage in extensive lip cancers.
http://www.ncbi.nlm.nih.gov/pubmed/7070090?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
Urea--treatment of liver metastases.
http://www.ncbi.nlm.nih.gov/pubmed/7318281?ordinalpos=16&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
Look at more yourself: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Danopoulos%20ED%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus
the first paper has no abstract and you have not presented the full paper, so no conclusions can be drawn a title doesnt indicate findings. The second one is about surgery and urea, the cancer metastisized to post cervical lymph nodes and they used surgery, gasp, not urea to treat it, another fail.
1: J Surg Oncol. 1982 Mar;19(3):127-31.Links
The effects of urea treatment in combination with
curettage in extensive lip cancers.Danopoulos ED, Danopoulou IE, Besbeas S, Ramantanis G.
Thirty cases of lip cancer in 28 patients, 23 of which were extensive or very extensive, were treated with local urea injections in combination with curettage. Out of the 30 cases there were 26 squamous cell carcinomas, three basal cell carcinomas extending to the mucosa from the skin of the lips, and one adenocarcinoma of the mucosa of the interior surface of the upper lip. This treatment was effective in all our patients. Recurrences appeared in four patients. These were easily treated in three out of the four patients who returned for treatment, by the same method.
In three cases metastases appeared in the lymphnodes of the neck, which were surgically treated.the other papers have no abstracts so no conclusion again, on top of that the eldor paper is a mere hypothesis with no testing. These papers are on the american society of cancers alternative page, did you not see that, they conclude that no prominent research has been done and well done studies show no effects.
lets see
1: Clin Oncol (R Coll Radiol). 2008 Dec;20(10):745-50. Epub 2008 Oct 8. Links
Raised serum urea predicts for early death in small cell lung cancer.Winter MC, Potter VA, Woll PJ.
Academic Unit of Clinical Oncology, University of Sheffield, Weston Park Hospital, Sheffield, UK.
AIMS: Previous studies have defined prognostic factors predicting a favourable response to treatment and long-term survival in small cell lung cancer (SCLC) patients. Here we sought specific pre-treatment features predicting early death in SCLC. MATERIALS AND METHODS: An exploratory cohort of 62 patients with poor prognosis SCLC and a separate confirmatory independent cohort of 152 unselected SCLC patients were identified to determine risk factors for early death, defined as within 8 weeks of diagnosis. RESULTS: In an exploratory cohort of patients with poor prognosis SCLC, 46 received chemotherapy and 16 patients received no chemotherapy. Multivariate analysis of chemotherapy patients showed a raised serum urea to be predictive of early death - increasing the risk by 13-fold (odds ratio 13.3, 95% confidence interval=2.8-64). In a separate cohort of 152 unselected SCLC patients, 123 received chemotherapy and 29 did not. Logistic regression analysis of treated patients showed that performance status >2 (P=0.009), urea>upper limit of normal (P=0.01), neutrophil count >10 (P=0.024) and weight loss >10% (P=0.03) significantly contributed to the risk of early death. Of note, raised serum urea increased the risk of early death by 12-fold (odds ratio 11.8, 95% confidence interval=1.8-76.9).
CONCLUSION: We have shown that pre-treatment raised serum urea is a significant predictor of early death. This readily available information will be useful for assessing SCLC patients at the bedside and discussing the risks of chemotherapy with them.strange conclusion no? since urea cures cancer, higher levels are predictive of death!!!!!!!!!!!!11
another
1: Br J Cancer. 1988 Mar;57(3):317-8.Links
Oral urea in the treatment of secondary tumours in the liver.Clark PI, Slevin ML, Webb JA, Osborne RJ, Jones S, Wrigley PF.
Department of Medical Oncology, St. Bartholomew's Hospital, London, UK.
Twenty patients with secondary liver tumours, predominantly from colorectal carcinoma, were treated with oral urea at a daily dose of 8 gm-2. Treatment was well tolerated without side-effects.
No objective responses were seen. It is concluded that oral urea is ineffective in the treatment of liver metastases from colorectal cancer.MOAR
1: Clin Oncol. 1984 Dec;10(4):341-4.Links
Oral urea in the treatment of colo-rectal liver metastases.Hooper TL, Rahman M, Magell J.
A consecutive series of 10 patients with hepatic metastases from colo-rectal carcinoma have been treated with oral urea. This substance has been reported to produce regression of hepatic secondaries from a variety of primary sources including colon. Although well tolerated, and leading to subjective improvement in some patients, no objective benefit has been confirmed from the treatment in this study.
http://www.cancer.org/docroot/ETO/content/ETO_5_3X_Urotherapy.asp?sitearea=ETOanother utter FAIL.
