Mon, Feb. 9, 2009Eating more fruits and vegetables, cutting down on calories and carbohydrates and increasing exercise are all-important parts of any healthy diet. But
according to new research at the University of Texas Southwestern Medical Center, Dallas, a low-carbohydrate diet burns more excess liver fat than a low-calorie diet.
Researchers in the small clinical study found that people on low-carbohydrate diets are more dependent on the oxidation of fat in the liver for energy than those on a low-calorie diet.
These findings could have implications for treating obesity and other related diseases like diabetes, insulin resistance and nonalcoholic fatty liver disease, says Dr. Jeffrey Browning assistant professor in the UT Southwestern Advanced Imaging Research Center and of internal medicine at the medical center and the study's lead author.
"Instead of looking at drugs to combat obesity and the diseases that stem from it, maybe optimizing diet cannot only manage and treat these diseases, but also prevent them," Dr. Browning says.
Glucose, a form of sugar, and fat are both sources of energy that are metabolized in the liver and used as energy in the body. For participants on the low-calorie diet, they received 40 percent of their glucose from glycogen, which comes from ingested carbohydrates and is stored in the liver until the body needs it. However, the low-carbohydrate dieters only received 20 percent of their glucose from glycogen. Instead of using their glycogen reserve, the subjects burned excess liver fat for energy.
"Energy production is expensive for the liver," Dr. Browning says. "It appears that for the people on a low-carbohydrate diet, in order to meet that expense, their livers have to burn excess fat. Understanding how the liver makes glucose under different dietary conditions may help us better regulate metabolic disorders with diet."
Although the original study was not designed to determine the effectiveness of one diet over the other, the average weight loss for low-calorie eaters was about five pounds, compared to nine and a half pounds for low-carbohydrate dieters. Results indicated that participants on the low-carbohydrate diet increased fat burning throughout the entire body.
http://www.philly.com/philly/living/CTW_health_20090209_Eat_to_Better_Living.html