I'm a big believer in sticking with the basic compound, strict, heavy movements mixed with isolation squeezes for my workouts...always have always will. But, every now and then, I throw little twists in..for example, my recent quad w/o consisted of the following:
Leg extensions 3 x 25
BB Squats 225 lbs...for 100 reps and the least amount of sets! It took me 4 sets...24, 24, 24, 28...I did NOT want to do another set, so I REALLY pushed it on the last set. It was really tough..diff than the usual( 4 x 6-8) for me. I did this w/o 2 days ago and I am def more sore than usual..nice curveball I threw myself! BTW these were all parallel squats, paused, with a box. Guaranteed...I don't cheat myself. Anyone wanna give it a try?