LMAO! Sorry dude but you have no fucking clue what you're talking about.
Aspirin inhibits prostaglandin production outside of the cells, which, in conjunction with caffeine, greatly prolongs the thermogenic effects and increased metabolism by sustaining elevated cAMP levels.
No offense to you bro and this isn't a personal attack but there are some fucking morons on this board and I've seen some really terrible advice from a lot of people concerning nutrition and steroids on here. Mods should do a better job of "modding" and weeding out the bullshit if they expect any real bodybuilders to seek out information and knowledge from getbig.
Studies have shown that aspirin is not required in the stack for weight loss (in non-obese people). Chronic use of aspirin is a good way to eat a hole in your gut. For the slight difference in thermogenic effect it might produce, I'd rather do a little extra cardio and eat less.
As far as modding goes, none of us are degreed medical physicians nor claim to be. We're just a bunch of people who enjoy the lifestyle and like sharing information and experience. As Mods, we're no more "experts" than some of the members.
That doesn't mean people reading the board should take that information blindly. Too many people come to these sites or walk into a GNC or go to a "real" medical Dr. and just blindly do or take what they say without doing their research. Ultimately, it comes down to personal choice and thinking for yourself.
For the most part this board is self policed by the participating members. It is everyone’s responsibility to contribute. We just help to maintain the board, enforce the rules and keep things from getting out of line.
Logical and civil arguments are fine. No flaming, bashing or personal attacks. Play nice and be respectful and generally everyone will respond in kind. Hopefully we can all get ideas and learn from each other.
Just a couple of studies on ECA..
: The Role of Caffeine, Ephedrine and Asprin by Mike Prevost PH.D - Muscle Growth and Fat Loss by stimulating the ß-agonist System, The Role of Caffeine, Ephedrine and Asprin
1: Int J Obes Relat Metab Disord. 1996 Feb;20(2):91-7.
Post-prandial thermogenesis with ephedrine, caffeine and aspirin in lean,
pre-disposed obese and obese women.
Horton TJ, Geissler CA.
Department of Nutrition and Dietetics, King's College, University of London,
Kensington, UK.
OBJECTIVE: To determine whether or not aspirin further potentiates the greater
post-prandial thermogenesis induced by ephedrine with caffeine. DESIGN:
Determination of the acute metabolic rate response to the following treatments:
1050 kJ liquid meal (M); meal plus ephedrine (30 mg) and caffeine (100 mg) (MEC)
or meal plus ephedrine, caffeine and aspirin (300 mg) (MECA). SUBJECTS: Lean,
pre-disposed obese and obese women (n = 10 each group). MEASUREMENTS: Pre- and
post-treatment metabolic rate determinations via indirect calorimetry.
Post-treatment measurements made at 20 min intervals for a total of 160 min.
RESULTS: In all groups, metabolic rate increased significantly more following
the MEC or MECA, compared to the meal only (p < 0.05). The obese group had a
significantly greater absolute increase in metabolic rate following the MECA and
MEC compared to both the lean and pre-disposed obese groups (p < 0.05).
Metabolic rate remained elevated at the end of the 160 min following all
treatments. CONCLUSION: Aspirin does not further potentiate the acute thermic
effect of ephedrine and caffeine with a meal. However, the full thermogenic
response was not measured and longer duration studies are necessary to confirm
these results.
PMID: 8646257 [PubMed - indexed for MEDLINE]
2: Int J Obes. 1991 May;15(5):359-66.
Aspirin potentiates the effect of ephedrine on the thermogenic response to a
meal in obese but not lean women.
Horton TJ, Geissler CA.
Department of Food and Nutritional Sciences, King's College (KQC), Kensington,
London, UK.
The effect of ephedrine (30 mg) and aspirin (300 mg) on the acute thermogenic
response to a liquid meal (250 kcal) was investigated in lean and obese women (n
= 10 each group). Resting metabolic rate (RMR) was measured prior to each of the
following treatments: meal only (M), meal plus ephedrine (ME) or meal plus
ephedrine and aspirin (MEA). Eight post-treatment measurements of metabolic rate
were made over a total of 160 minutes. Rise in post-treatment metabolic rate was
compared to the baseline RMR. Following the M treatment, the mean increase in
metabolic rate was 0.17 +/- 0.01 and 0.13 +/- 0.02 kcal/min in the lean and
obese groups respectively, with the corresponding rises being 0.21 +/- 0.02 and
0.19 +/- 0.02 kcal/min following the ME, and 0.23 +/- 0.03 and 0.23 +/- 0.01
kcal/min following the MEA. The increase in post-prandial thermogenesis with the
ephedrine or ephedrine plus aspirin was significant in the obese group (P less
than 0.03 and P less than 0.001 respectively) but not the lean. Furthermore, the
post-treatment rise in metabolic rate, following the MEA treatment compared to
the ME, was significantly greater for the obese group (P less than 0.05) but not
the lean. It was concluded that aspirin potentiates the stimulatory effect of
ephedrine on the thermogenic response to a meal in obese but not lean women.
