« previous next »
Pages: [1]   Go Down

Author Topic: want to roll harder? ditch the anti estrogens  (Read 2406 times)

tbombz

  • Getbig V
  • *****
  • Posts: 19350
  • Psalms 150
want to roll harder? ditch the anti estrogens
« on: September 11, 2009, 03:14:44 PM »
An interesting observation is that females seem to be much more sensitive to the subjective and neurotoxic effects of MDMA (66). This too is probably related to hormones. Estrogen has a substantial activating effect on 5-HT neurotransmission, upregulating tryptophan hydoxylase, decreasing both 5-HT transporter mRNA and the sensitivity of 5-HT (1A) autoreceptors (67).

66. Liechti ME, Gamma A, Vollenweider FX. Gender differences in the subjective effects of MDMA. Psychopharmacology (Berl). 2001 Mar 1;154(2):161-8.
67. McEwen B. Estrogen actions throughout the brain. Recent Prog Horm Res. 2002;57:357-84.
Logged

ManBearPig...

  • Getbig V
  • *****
  • Posts: 12280
  • Professional Fighter
Re: want to roll harder? ditch the anti estrogens
« Reply #1 on: September 11, 2009, 03:15:49 PM »
Logged
Deep Tissue Massage

JimmyJam1974

  • Getbig V
  • *****
  • Posts: 5779
  • "No sir, the ball ain't heavy." - Herschel Walker
Re: want to roll harder? ditch the anti estrogens
« Reply #2 on: September 11, 2009, 04:03:14 PM »
1997 called, they want their drugs back.
Logged
U

aglifter

  • Getbig III
  • ***
  • Posts: 442
  • Conan! What is best in life?
Re: want to roll harder? ditch the anti estrogens
« Reply #3 on: September 11, 2009, 07:06:43 PM »
english please

Quote from: tbombz on September 11, 2009, 03:14:44 PM
An interesting observation is that females seem to be much more sensitive to the subjective and neurotoxic effects of MDMA (66). This too is probably related to hormones. Estrogen has a substantial activating effect on 5-HT neurotransmission, upregulating tryptophan hydoxylase, decreasing both 5-HT transporter mRNA and the sensitivity of 5-HT (1A) autoreceptors (67).

66. Liechti ME, Gamma A, Vollenweider FX. Gender differences in the subjective effects of MDMA. Psychopharmacology (Berl). 2001 Mar 1;154(2):161-8.
67. McEwen B. Estrogen actions throughout the brain. Recent Prog Horm Res. 2002;57:357-84.
Logged

The Master

  • Getbig V
  • *****
  • Posts: 13785
Re: want to roll harder? ditch the anti estrogens
« Reply #4 on: September 11, 2009, 07:18:48 PM »
Quote from: tbombz on September 11, 2009, 03:14:44 PM
An interesting observation is that females seem to be much more sensitive to the subjective and neurotoxic effects of MDMA (66). This too is probably related to hormones. Estrogen has a substantial activating effect on 5-HT neurotransmission, upregulating tryptophan hydoxylase, decreasing both 5-HT transporter mRNA and the sensitivity of 5-HT (1A) autoreceptors (67).

66. Liechti ME, Gamma A, Vollenweider FX. Gender differences in the subjective effects of MDMA. Psychopharmacology (Berl). 2001 Mar 1;154(2):161-8.
67. McEwen B. Estrogen actions throughout the brain. Recent Prog Horm Res. 2002;57:357-84.

T-BRAIN TO THE RESCUE
Logged

tbombz

  • Getbig V
  • *****
  • Posts: 19350
  • Psalms 150
Re: want to roll harder? ditch the anti estrogens
« Reply #5 on: September 11, 2009, 07:19:12 PM »
Quote from: aglifter on September 11, 2009, 07:06:43 PM
english please

estrogen makes ecstacy work better
Logged

2Thick

  • Getbig IV
  • ****
  • Posts: 1703
  • His Thickness
Re: want to roll harder? ditch the anti estrogens
« Reply #6 on: September 11, 2009, 08:02:10 PM »
Quote from: tbombz on September 11, 2009, 07:19:12 PM
estrogen makes ecstacy work better

Does it also make one crave anal deep tissue massage more as well?
Logged
A

flexingtonsteele

  • Competitors II
  • Getbig V
  • *****
  • Posts: 5653
  • The new age pussy Punisher!
Re: want to roll harder? ditch the anti estrogens
« Reply #7 on: September 11, 2009, 08:02:54 PM »
Quote from: 2Thick on September 11, 2009, 08:02:10 PM
Does it also make one crave anal deep tissue massage more as well?

what, u didnt read that part of the article  ::)
Logged

2Thick

  • Getbig IV
  • ****
  • Posts: 1703
  • His Thickness
Re: want to roll harder? ditch the anti estrogens
« Reply #8 on: September 11, 2009, 08:10:17 PM »
Quote from: flexingtonsteele on September 11, 2009, 08:02:54 PM
what, u didnt read that part of the article  ::)

I guess I was expecting a personal anecdote. You're not tbombz, but how about you? Do you have any light to shed on my question yourself? Thanks in advance.
Logged
A

Rami

  • Getbig V
  • *****
  • Posts: 8120
  • One Hundred Percent
Re: want to roll harder? ditch the anti estrogens
« Reply #9 on: September 12, 2009, 01:01:49 AM »
how else would one be able to go through life being born female.
Logged

Mars

  • Time Out
  • Getbig V
  • *
  • Posts: 27707
Re: want to roll harder? ditch the anti estrogens
« Reply #10 on: September 12, 2009, 01:35:04 AM »
Logged
Pages: [1]   Go Up
« previous next »