Manny was able to utilize his speed against a very slow De La Hoya and Hatton who has zero technical boxing skills.
Cotto is as much of a boxing technician as you'll ever see in the sport. The holes in ODLH and Hatton's defense won't be there.
I like both fighter's equally, but Cotto is a huge step up in competition. The last time Manny fought someone as dangerous was Juan Manuel Marquez, but Cotto is more technical and powerful.
If Cotto can handle Mosley's explosiveness then he can handle Pacman's. This fight will come down to whether Pacman has become a boxer and not a brawler.