Not at all. It's easier for me to shoot my calves than my quads and shoulders, and I shoot my quads quite often as well.
Funny, you're the complete opposite of me. I got to where I never injected my quads anymore, too much irritation for some reason. Shoulders, glutes and pecs were always my mainstay, triceps occasionally...biceps a few times but I never really cared for bicep injections, it would get so tight in there I could hardly move my arms, lol!