Take it from me, if you roll off the gain and give Moore a strat with no single coils and asked him to do what Mayer or Stevie Ray does he wouldn't know where to start. Well maybe he would, but conversely, give Mayer a massive sounding pair of high output humbuckers and he could shred endlessly if he wanted to. Moore is great but that rock style takes less nuanced playing than the proper bluesy stuff, because it's all turned up to 11. You could argue it sounds better, and I couldn't disagree, but it's easier than what Mayer does.