Can you imagine what Dr. Albert Hoffman the doctor who synthesized LSD was thinking when he first tried it? The usual dosage is like 50-150micrograms, but his first dose was 25 milligrams!! Holy shit that must have been intense
Actually Hoffman only took 250 micrograms on his first trip. Or 0.25 miligrams. Enough for a solid trip, equal to 3 or 4 blotters.
If he would have took 25 milligrams of LSD he would have tripped for a couple weeks and probably would have gone insane. 25 milligrams would probably turn a lot of people into a vegetable for while.
From Wikipedia:
April 19, 1943, Hofmann performed a self-experiment to determine the true effects of LSD, intentionally ingesting 0.25 miligrams (250 micrograms of the substance, an amount he predicted to be a threshold dose (an actual threshold dose is 20 micrograms).[6] Less than an hour later, Hofmann experienced sudden and intense changes in perception. He asked his laboratory assistant to escort him home and, as use of motor vehicles was prohibited because of wartime restrictions, they had to make the journey on a bicycle. On the way, Hofmann’s condition rapidly deteriorated as he struggled with feelings of anxiety, alternatingly believing the next-door neighbor was a malevolent witch, that he was going insane, and the LSD had poisoned him. When the house doctor arrived, however, he could detect no physical abnormalities, save for a pair of incredibly dilated pupils. Hofmann was reassured, and soon his terror began to give way to a sense of good fortune and enjoyment, as he later wrote
"... little by little I could begin to enjoy the unprecedented colors and plays of shapes that persisted behind my closed eyes. Kaleidoscopic, fantastic images surged in on me, alternating, variegated, opening and then closing themselves in circles and spirals, exploding in colored fountains, rearranging and hybridizing themselves in constant flux ..."
