Most Prohormones May be Gone in SIX Months!

[DK II]

Oh absolutely. I'd love to see Falcon Punches thrown in the oval office. Sarah Palin for VP- she's got a sweet ass on her booooy.

You missed the point, "dumby".

[Alexander D]

Diagnosis is usually caught by accident for example doing a liver value test based on symptoms brought on by blocked ducts. So what specific cancer maker test is used while tracking Cholangiocarcinoma?

LMAO and you know this from something you read on google, right? LOL Give up bro.

It is often a difficult diagnosis to make, we see it more commonly in patients with UC, so certainly those patients are monitored closer than you would for the general population.

Define- "TRACKING" I am not a bloodhound. I do not "TRACK" anything.

If you read my previous post, I've already told you that tumor markers mean VERY VERY little. CEA, CA19/9, biliary insulin-like growth factor... They are one tiny part of the giant algorithm and mean very little for diagnosis.

[DK II]

LMAO and you know this from something you read on google, right? LOL Give up bro.

It is often a difficult diagnosis to make, we see it more commonly in patients with UC, so certainly those patients are monitored closer than you would for the general population.

Define- "TRACKING" I am not a bloodhound. I do not "TRACK" anything.

If you read my previous post, I've already told you that tumor markers mean VERY VERY little. They are one tiny part of the giant algorithm.

You're surely trying very hard here.

[Disgusted]

LMAO and you know this from something you read on google, right? LOL Give up bro.

It is often a difficult diagnosis to make, we see it more commonly in patients with UC, so certainly those patients are monitored closer than you would for the general population.

Define- "TRACKING" I am not a bloodhound. I do not "TRACK" anything.

If you read my previous post, I've already told you that tumor markers mean VERY VERY little. They are one tiny part of the giant algorithm.

No I know this not from google but from someone that I knew who died from it and as far as using the word "track" this is the word that the Dr used to keep an eye on the progress of the disease so I am not sure why you find that so unusual.

[Alexander D]

No I know this not from google but from someone that I knew who died from it and as far as using the word "track" this is the word that the Dr used to keep an eye on the progress of the disease so I am not sure why you find that so unusual.

As i've stated in previous posts, there isn't 1 specific PERFECT tumor marker that we follow for someone with cholangio...

We look at CEA, CA 19/9, Biliary Insulin-like growth factor (sometimes)... its important to have pre-op/pre-treatment values to compare to post-treatment values for follow up. This Doc may have followed the only tumor marker that was drawn pre-treatment... this DOESNT mean that everyone follows this specific marker for that type of cancer. do you understand?

Did your friend have Ulcerative Colitis or Primary Scherolsing Cholangitis prior to his diagnosis of cholangio ca... and was the cancer Adeno (glandular, most common- about 80% of cholangio ca) or squamous cell varient? (far less common)

For a lot of other cancers tumor markers mean much more... Breast Cancer and the BRCA1 and 2 mutations have been researched a shit load and are now used in genetic counseling of family members... other cancers we are still WAY behind... for example- pancreatic cancer research is my area of interest. That is def one son of a bitch that you don't want to get... My old med school anatomy professor told me if you get pancreatic CA "Get yourself a bottle of champagne, a blonde whore and kiss your ass good bye" LOL Sadly, times haven't changed much.

[Alexander D]

Either way, sorry for your loss... It's a terrible cancer... Up there with Pancreatic and esophageal in my opinion with respect to long term prognosis/ survival.

[Disgusted]

As i've stated in previous posts, there isn't 1 specific PERFECT tumor marker that we follow for someone with cholangio...

We look at CEA, CA 19/9, Biliary Insulin-like growth factor (sometimes)... its important to have pre-op/pre-treatment values to compare to post-treatment values for follow up. This Doc may have followed the only tumor marker that was drawn pre-treatment... this DOESNT mean that everyone follows this specific marker for that type of cancer. do you understand?

Did your friend have Ulcerative Colitis or Primary Scherolsing Cholangitis prior to his diagnosis of cholangio ca... and was the cancer Adeno (glandular, most common- about 80% of cholangio ca) or squamous cell varient? (far less common)

No history of Uc or PSC and not sure bout the second.

[Alexander D]

What stage was she diagnosed? What treatment did she receive? How long did she survive following diagnosis?

[Disgusted]

Either way, sorry for your loss... It's a terrible cancer... Up there with Pancreatic and esophageal in my opinion with respect to long term prognosis/ survival.

OK well thanks honestly. Very sad and she was only 56.

[Alexander D]

OK well thanks honestly. Very sad and she was only 56.

All BS aside, i am sorry to hear that... 56 is way too young.

[Disgusted]

What stage was he diagnosed? What treatment did he receive? How long did he survive following diagnosis?

Well its was inoperable and chemo was done, but basically was a waste of time. She lasted about 4 months but actually died from and intestinal blockage. Funny thing is she never once looked sick and actually was working up until the time she died.

[225for70]

All hail Disgusted- GETBIG.COM EXPERT. JACK OF EVERYTHING, MASTER OF NOTHING.

Disgusted is one of the most knowledgeable guys on the bodybuilding scene..He doesn't need to spew "he's not a doctor in every post." none the less in anything related to bodybuilding and Losing weight i would take disgusted's word over any doctor.

[Alexander D]

Well its was inoperable and chemo was done, but basically was a waste of time. She lasted about 4 months but actually died from and intestinal blockage. Funny thing is she never once looked sick and actually was working up until the time she died.

Hmm... Was she enrolled in a clinical trial for the chemo? Where did she go, to a high volume academic hospital or community?

By and large, most GI cancers that are inoperable (usually because of presense of metastatic disease at the time of dianosis) have a terrible prognosis. Good for her that she never really got sick and was working until she died.

We sometimes operate on patients who are good surgical candidates who have for example an isolated liver met... but widely metastatic disease no surgeon will touch because it's not been shown to improve long term survival... Instead it makes their quality of life even WORSE their last few months... because now they have to heal from a big operation and its impossible to resect microscopic mets and even the gross tumor-debulking is difficult at times.

I could never do Med Onc because basically you are telling patients "You are probably going to die soon, but hopefully this new chemo drug we have can help buy you a few months, or maybe more. we aren't really sure. Lets see how you do and hopefully you wont have too many side effects" Being open and honest with your patients being as important as it is, it would be tough to have that conversation every day... Fortunately for us, we usually get to see the patients who end up doing pretty well.

[225for70]

Just wanted all you buck tooth jack asses to know, I will officially be a doctor very soon..

[Alexander D]

Just wanted all you buck tooth jack asses to know, I will officially be a doctor very soon..

Wait, are you black?

[Disgusted]

Hmm... Was she enrolled in a clinical trial for the chemo? Where did she go, to a high volume academic hospital or community?

By and large, most GI cancers that are inoperable (usually because of presense of metastatic disease at the time of dianosis) have a terrible prognosis. Good for her that she never really got sick and was working until she died.

We sometimes operate on patients who are good surgical candidates who have for example an isolated liver met... but widely metastatic disease no surgeon will touch because it's not been shown to improve long term survival... Instead it makes their quality of life even WORSE their last few months... because now they have to heal from a big operation and its impossible to resect microscopic mets and even the gross tumor-debulking is difficult at times.

I could never do Med Onc because basically you are telling patients "You are probably going to die soon, but hopefully this new chemo drug we have can help buy you a few months, or maybe more. we aren't really sure. Lets see how you do and hopefully you wont have too many side effects" Being open and honest with your patients being as important as it is, it would be tough to have that conversation every day... Fortunately for us, we usually get to see the patients who end up doing pretty well.

No far as I know the Dr just gave her some kind of chemo that may have been the same drugs that they use for breast cancer as I was under the impression that bile duct cancer has no protocol when it comes to chemo. Even after the chemo didn't work they still wanted to give her more and when asked if this would help her survival they said it won't?? Jesus at that point it was all about the money at 11K a pop what else could it be.

She did start to use a drug on her own and her cancer maker went down 7000 points in one month and this drug has actually put some with bile duct cancer into remission, but like i said she actually died from an intestinal blockage.

[Disgusted]

Disgusted is one of the most knowledgeable guys on the bodybuilding scene..He doesn't need to spew "he's not a doctor in every post." none the less in anything related to bodybuilding and Losing weight i would take disgusted's word over any doctor.

Thanks and I can tell you that I have researching diet and nutrition for way over 20 years and still do. I love it and think it's fun. Believe it or not I am way more interested in using diet for longevity purposes than BBing. Peaking for a show is all about diet and NOT drugs. If drugs where it when everyone would peak perfectly and in todays world the majority don't peak correctly. Years ago you rarely say guys miss their peak. I gotta be honest I hate the direction that BBing is going today as there is just way to much emphasis on drugs instead of diet.

[Alexander D]

No far as I know the Dr just gave her some kind of chemo that may have been the same drugs that they use for breast cancer as I was under the impression that bile duct cancer has no protocol when it comes to chemo. Even after the chemo didn't work they still wanted to give her more and when asked if this would help her survival they said it won't?? Jesus at that point it was all about the money at 11K a pop what else could it be.

She did start to use a drug on her own and her cancer maker went down 7000 points in one month and this drug has actually put some with bile duct cancer into remission, but like i said she actually died from an intestinal blockage.

Hmmm... Survival time isn't the only issue that needs to be considered... (Although for family members this is often the most important question they want answered "HOW LONG ARE THEY GOING TO LIVE DOCTOR"...) Quality of life, in terms of getting rid of symptoms/preventing others, pain management etc etc all are part of the equation. I really cannot speak on why they did what they did. There are a few albumin-tagged drugs used with fairly good success for metastatic breast cancer. Abraxis Bioscience, which was just bought out by Celegene, has a drug called Abraxane (not sure if the name has changed now that the company was bought) but either way, not sure if there is any data on its utility for cholangio. My guess is there isn't any.

The 3 most common causes of intestinal obstruction (we are talking small and large bowel) are Adhesions from prior surgery, hernias and CANCER... And given her history of cancer, my guess is that she had mets all over the place by the time she passed. Not a fun way to go, but I'm glad to hear she didn't suffer much.

[Alexander D]

Once she was deemed inoperable, the tumor markers would continue to be drawn with routine labs, to see how/if the chemo is working, but really it doesn't provide a TON of help most of the time at that moment. Inoperable Cholanio- 3-6 months is usually the survival i have seen with no treatment or equivical (shitty chemo that doesnt help)

Our lab is very actively involved in tumor biology research, hopefully in a few years we will have a better understanding of pathways of more cancers and we will know what to look for way in advance.

[Disgusted]

Hmmm... Survival time isn't the only issue that needs to be considered... (Although for family members this is often the most important question they want answered "HOW LONG ARE THEY GOING TO LIVE DOCTOR"...) Quality of life, in terms of getting rid of symptoms/preventing others, pain management etc etc all are part of the equation. I really cannot speak on why they did what they did. There are a few albumin-tagged drugs used with fairly good success for metastatic breast cancer. Abraxis Bioscience, which was just bought out by Celegene, has a drug called Abraxane (not sure if the name has changed now that the company was bought) but either way, not sure if there is any data on its utility for cholangio. My guess is there isn't any.

The 3 most common causes of intestinal obstruction (we are talking small and large bowel) are Adhesions from prior surgery, hernias and CANCER... And given her history of cancer, my guess is that she had mets all over the place by the time she passed. Not a fun way to go, but I'm glad to hear she didn't suffer much.

Yes Abraxane uses a human albumin protein to coat taxol and doesn't need premeds like reg taxol but some have still got bad effect from it just like taxol, but at the same time they use it in a higher dose which to me makes not sense. I believe that this is the only one of it's kind on the market. Also Abraxane is only used after Taxol has been shown to be too toxic. Far as I know it is not being used for bile duct cancer.

[225for70]

Thanks and I can tell you that I have researching diet and nutrition for way over 20 years and still do. I love it and think it's fun. Believe it or not I am way more interested in using diet for longevity purposes than BBing. Peaking for a show is all about diet and NOT drugs. If drugs where it when everyone would peak perfectly and in todays world the majority don't peak correctly. Years ago you rarely say guys miss their peak. I gotta be honest I hate the direction that BBing is going today as there is just way to much emphasis on drugs instead of diet.

I agree with pretty much everything...A dieting for cutting and longevity differ greatly..The consensus of what's healthy changes from day to day by the medical community...As well how bodybuilders diet for shows..You can see the dependence on bodybuilding drugs in the shit you see on IFBB stage these days..


I'm only curious as to what you think is the max protein a person who wants to gain muscle should consume for anabolism?

[Disgusted]

I agree with pretty much everything...A dieting for cutting and longevity differ greatly..The consensus of what's healthy changes from day to day by the medical community...As well how bodybuilders diet for shows..You can see the dependence on bodybuilding drugs in the shit you see on IFBB stage these days..


I'm only curious as to what you think is the max protein a person who wants to gain muscle should consume for anabolism?

One to 1.5 gr per pound, but I tend to lean towards one. I think people eat too much protein to begin with and I personally don't like whey.

[Disgusted]

Once she was deemed inoperable, the tumor markers would continue to be drawn with routine labs, to see how/if the chemo is working, but really it doesn't provide a TON of help most of the time at that moment. Inoperable Cholanio- 3-6 months is usually the survival i have seen with no treatment or equivical (shitty chemo that doesnt help)

Our lab is very actively involved in tumor biology research, hopefully in a few years we will have a better understanding of pathways of more cancers and we will know what to look for way in advance.

OK would you happen to know why her marker went down so quickly in one month time? To me this is indicative to the drug she was taking starting to work, maybe not??

[DK II]

Just wanted all you buck tooth jack asses to know, I will officially be a doctor very soon..

I also have a doctors degree in internet bullshitting in medicine, nutrition, training and politics. 

[225for70]

I also have a doctors degree in internet bullshitting in medicine, nutrition, training and politics. 

I'm attempting to get a doctrine in finance..I finished my MBA about 1.5 years ago..