I wouldn't take choline with racetams due to risk of excessive stimulation of nicotinic receptors and neurotoxicity. If you take choline, refrain from taking dopaminergics as choline already increases dopamine turnover and too much dopamine synthesis/accumulation significantly increases oxidative stress.
If you put together a nootropic blend that includes choline, then I would recommend staking it with low doses of a trycyclic like amytriptline or other. MAOIs are even better at resoring brain levels of catecholamines and indolamines, but they are too dangerous in my opinion. It is particularly difficult to take them following a bodybuilding diet.
Avoid choline and antidepressants and just take racetams with Magnesium glycinate or gluconate which have very high bioavailability, and load up on neurotransmitter precursors. I don't recommend l-tyrosine because it boosts norepinephrine synthesis at the expense of dopamine, and the latter is the preferred amine. Take instead d,l-phenylalanine which favors dopamine or very low doses of l-dopa. i don't recommend l-dopa because it increases oxidative stress significantly, but it is safe in low doses.
SUCKMYMUSCLE
Acta Pol Pharm. 2005 Sep-Oct;62(5):405-9.
Piracetam--an old drug with novel properties?
Winnicka K, Tomasiak M, Bielawska A.
Source
Department of Drug Technology, Medical University of Białystok, 1 Kilińskiego Str., 15-089 Białystok, Poland.
Abstract
Piracetam (2-oxo-1-pyrrolidine-acetamide), the most common of the nootropic drugs, is a cyclic derivative of gamma-aminobutyric acid. The treatment with piracetam improves learning, memory, brain metabolism, and capacity. Piracetam has been shown to alter the physical properties of the plasma membrane by increasing its fluidity and by protecting the cell against hypoxia. It increases red cell deformability and normalizes aggregation of hyperactive platelets. Piracetam is an agent with antithrombotic, neuroprotective and rheological properties. The interaction of this molecule with the membrane phospholipids restores membrane fluidity and could explain the efficacy of piracetam in various disorders ranging from dementia and vertigo to myoclonus and stroke.
This study in full text talks about how it improve ach function at the receptor through ligand binding. What exactly this means we are unsure, however, i do like your advise as it does err on the cautious side. People often cite choline usage because piracetam is said to deplete choline, as in increase turnover thus supplementing would allow the benefits to remain. I have tried both ways and like adding choline, from a safety standpoint i would say if it is to become a staple in a stack then choline may have negative effects. Its actually really hard to say, the dat ajust isnt there
