This could very well backfire on him. I know that part of his onscreen allure is his witty humor, but that comes packaged in with his overweight, goofy-looking Jewish persona.
You take away the fat and he is just another witty guy. It's hard to laugh at John Candy or Chris Farley without the 200+ pounds of excess fat that make them great targets to laugh at.
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Oddly enough I think that is why fat people in Hollywood don't lose weight. I can see their agent telling them "you will never be a sex symbol, and you are typed cast as the fat funny person". Losing weight for the fringe actor is a risky proposition, one where the consequences may mean less work.
for the me, If I were a guy in Hollywood I would live, eat, sleep and breath on HGH. A low enough dosage where I could lie and say it is all because of my diet and tabata training.