Its a shame that such a good topic sands again in flaming and bashing. You don't have to agree with each other, thats why its a DISCUSSION form.
I especially like the subjects of injectable 17 alpha methylated oral available roids. Old scientific studies patents from Ciba shows that from the beginning Ciba patented injectable Dianabol I wrote about it here:
http://juicedmuscle.com/jmblog/content/dianabolr-history-use-and-dosagesPersonally I believe its only a fraction hepatotoxic compared to oral usage and even that is highly exagerated. The old Ciba research also showed that an increased metabolism (by example from using T3 increases excretion and thus decreases bioavailability)
Also the fact (?) that IV is superior to sub-q?
A detailed pamphlet on subcutaneous injections in PDF form is available from the National Institutes of Health. It provides background, detailed instructions and some useful tips. It will be particularly useful to patients who elect to self-administer any part of their therapy in this form and generally helpful to anyone who wants to understand this important delivery mechanism.
The effect of the size of the drug molecule makes a difference. Remember, we said blood capillaries are like fine tubes with very small pores through which stuff passes from the blood system into the lymph pools around cells. Drugs that are composed of small, water soluble molecules are readily taken up by the blood circulation. Larger molecules, or those that are more fat soluble, do not find it easy to get in through the fine holes in the blood capillaries. These types of drug molecules stay in the lymphatic system, gradually working their way through the many lymph nodes and the like, until they are finally returned back into the blood circulation when the lymph drains back at the junction of your jugular and subclavian veins.
Sounds interesting, right? If even a small percent of the drug travels through the lymphatic system, as opposed to the general blood circulation, you might expect to get more bang for the buck, right? Right. The second abstract below shows that subcutaneous injection is more efficient than intravenous administration,
for fludarabine administration in Lupus. The efficiency of oral, IV and subcutaneous administration are, respectively, 54: 100: 105.The formulations of the old injectables where amde of PEG and PG. Newer ones with "super solvent" Guiacogol and today with newer methods like cold solving and "wetting" I posted about it here:
http://juicedmuscle.com/showthread.php?4648-Oxy-ject&p=37811http://juicedmuscle.com/archive/index.php/t-4249.html