If it's so liver toxic, what exactly is its clinical use in studies?
I did a 6 week cycle of Tren just to see how my body felt on it......and I like it.
It's a nice drug to stack with Test and Winstrol.
Not as nice as Halotestin though.
DIV
As far as current research uses, I'm not sure what all purposes would be, though I've seen it used multiple times in determining androgen binding activity (for example when studying androgen receptor mutations).
Here are a few studies done w/ methyltrienolone:
Tremblay RR, Dube JY, Ho-Kim MA, Lesage R. Determination of rat muscles androgen-receptor complexes with methyltrienolone. Steroids. 1977 Feb;29(2):185-95.
Asselin J, Labrie F, Gourdeau Y, Bonne C, Raynaud JP. Binding of [3H] methyltrienolone (R 1881) in rat prostate and human benign prostatic hypertrophy (BPH). Steroids. 1976 Oct;28(4):449-59.
Kruskemper HL, Noell G. Liver toxicity of a new anabolic agent: methyltrienolone (17-alpha-methyl-4,9,11-estratriene-17 beta-ol-3-one). Steroids. 1966 Jul;8(1):13-24.
And here's a good write-up regarding that last study by Kruskemper:
"Studies were done on 13 humans in Germany in 1966. GPT and GOT livervalues were measured. Now the max value of GPT (glutamaatpyruvaattransam
inases) is 12.5 mu/ml. Some subjects got 0.1 (!) mg methyltrienolone per day and saw their GPT rise from
4.50 mu/ml to 224.0 mu/ml in only 2 weeks! That's fifty times higer than normal. Not two or three. Fifty! After a week off it was still at 68 mu/ml.
Some subjects who got the full 1.0mg/day saw their GPT rise to 299 mu/ml.
GOT (glutamaatoxalacetaatrans
aminases) testing: same explosive increase to highly pathologic values in two weeks.
Cholinesterase enzyme lowered in the 1.0 mg group. That damage was permanent.
Not only is methyltrienolone the most hepatoxic steroid, it is also the most androgenic with a 'displacing ability' of 165%. It is also the most prostate unfriendly.
All 13 test subjects suffered permanent liver damage. They all also exhibited poisoning symptoms during the 2 week cycle, even de 0.1mg group."