Getbig Bodybuilding, Figure and Fitness Forums
July 29, 2014, 12:39:32 PM *
Welcome, Guest. Please login or register.

Login with username, password and session length
 
   Home   Help Calendar Login Register  
Pages: [1]   Go Down
  Print  
Author Topic: Glutamine potentially dangerous?  (Read 1410 times)
WOOO
Getbig V
*****
Gender: Male
Posts: 15890


Mr. Unpopular


View Profile
« on: January 10, 2013, 05:03:40 AM »

http://www.ncbi.nlm.nih.gov/pubmed/22990615

Side Effects of Long-term Glutamine Supplementation.

Holecek M.

Source
Charles University in Prague, Hradec Kralove, Czech Republic.

Abstract

Some people consume chronically glutamine (GLN) in high quantities (~40 g/d), although a number of biochemical pathways and cellular functions may be negatively affected. The following side effects of GLN supplementation are discussed: (1) Alterations in amino acid transport-as GLN shares the transporters with other amino acids, enhanced GLN intake may impair amino acid distribution among tissues and their absorption in the gut and kidneys. (2) Alterations in GLN metabolism-GLN supplementation may impair synthesis of endogenous GLN and enhance glutamate and ammonia production. (3) Alterations in ammonia transport-GLN supplementation may impair ammonia detoxification and negatively affect the role of GLN as the carrier of ammonia among tissues. (4) Abnormalities in aminoacidemia-increased plasma levels of GLN, glutamate, citrulline, ornithine, arginine, and histidine and decreased levels of valine, leucine, isoleucine, glycine, threonine, serine, and proline are reported. (5) Alterations in immune system-as GLN has immunomodulating properties, the effect of chronic GLN consumption on the immune system needs to be assessed. (6) Effect on tumor growth-it should be elucidated whether chronic intake of GLN increases the risk of cancer. (7) Effect of the withdrawal of GLN supplementation-due to the adaptive response of the organism to enhanced GLN consumption, the withdrawal of GLN may enhance the risk of health problems resulting from GLN deficiency. It is concluded that enhanced intake of GLN has substantial side effects, and long-term studies should be performed to justify chronic consumption of a GLN-enriched diet.
Report to moderator   Logged
Montague
Moderator
Getbig V
*****
Gender: Male
Posts: 11836



View Profile
« Reply #1 on: January 10, 2013, 07:45:01 AM »

I remember years ago, our own Necrosis (yousmokepole) mentioned the concept of certain amino acids competing with the transport of others, and thus should not be taken together. I don't recall any further elaboration, but #1 above explains it.

This is the first I've heard of glutamine's other sides; some of them pretty serious, too. As an OTC supplement, I doubt this will receive the proper research it deserves to determine its longterm safety - at least not anytime soon.

I briefly used glutamine years ago, noticed nothing, and discontinued.

Great abstract!
Report to moderator   Logged
a_ahmed
Getbig V
*****
Posts: 5754


Team Nasser


View Profile
« Reply #2 on: January 10, 2013, 03:56:46 PM »

Glutamine + vit c helps me heal faster/not get sick. It also seems to mildly help with recovery that's about it... And I did in fact come upon medical journals which illustrate its benefit in healing, preventing infections, speeding healing/infections/etc... as it is one of the main ingredients in the building up of the immune system
Report to moderator   Logged
njflex
Getbig V
*****
Gender: Male
Posts: 18999


team guido


View Profile
« Reply #3 on: January 10, 2013, 04:45:55 PM »

used it for while yrs ago on own,,couple protein shakes a day will recover and fill muscle,,stopped it yrs ago ,,no change,,
Report to moderator   Logged

$
Princess L
Moderator
Getbig V
*****
Gender: Female
Posts: 10200


I stop for turtles


View Profile
« Reply #4 on: January 10, 2013, 06:32:51 PM »

I remember years ago, our own Necrosis (yousmokepole) mentioned the concept of certain amino acids competing with the transport of others, and thus should not be taken together. I don't recall any further elaboration, but #1 above explains it.

This is the first I've heard of glutamine's other sides; some of them pretty serious, too. As an OTC supplement, I doubt this will receive the proper research it deserves to determine its longterm safety - at least not anytime soon.

I briefly used glutamine years ago, noticed nothing, and discontinued.

Great abstract!

Isn't this the same reason it's always been said it's a waste to mix your BCAA's with your protein shake?
Report to moderator   Logged

:
WOOO
Getbig V
*****
Gender: Male
Posts: 15890


Mr. Unpopular


View Profile
« Reply #5 on: January 10, 2013, 06:37:56 PM »

Isn't this the same reason it's always been said it's a waste to mix your BCAA's with your protein shake?


i've heard that too and read the theoretical reasons why but have never found a study proving it...

PS: where ya bin? when you're not here we're stuck with monty and he's MEAN
Report to moderator   Logged
Montague
Moderator
Getbig V
*****
Gender: Male
Posts: 11836



View Profile
« Reply #6 on: January 10, 2013, 06:40:39 PM »


i've heard that too and read the theoretical reasons why but have never found a study proving it...

PS: where ya bin? when you're not here we're stuck with monty and he's MEAN


Hey, fukk you, ass-face. I'm not mean!
Report to moderator   Logged
Montague
Moderator
Getbig V
*****
Gender: Male
Posts: 11836



View Profile
« Reply #7 on: January 10, 2013, 06:42:12 PM »

 Grin
Report to moderator   Logged
WOOO
Getbig V
*****
Gender: Male
Posts: 15890


Mr. Unpopular


View Profile
« Reply #8 on: January 10, 2013, 06:50:03 PM »


Hey, fukk you, ass-face. I'm not mean!


hahaha... best insult on the nutrition board in years!
Report to moderator   Logged
Montague
Moderator
Getbig V
*****
Gender: Male
Posts: 11836



View Profile
« Reply #9 on: January 10, 2013, 06:58:25 PM »

Isn't this the same reason it's always been said it's a waste to mix your BCAA's with your protein shake?


Traditionally, that seems to have been the case. Although, it never made much sense to me with whey shakes since they contain BCAA's already; what's the harm in adding a few more?

Now, I'm noticing that some BCAA product labels mention adding them to your protein drinks or favorite beverage.

In terms of sports nutrition, the branched chain amino's serve to stimulate global rates of protein synthesis in skeletal muscle. Since that is the case, then it makes sense to ingest them in the presence of other complete proteins. By themselves, they seem much less effective.

Donkey Kong and I had some discussions about this some time ago.

Report to moderator   Logged
Montague
Moderator
Getbig V
*****
Gender: Male
Posts: 11836



View Profile
« Reply #10 on: January 10, 2013, 06:58:54 PM »


hahaha... best insult on the nutrition board in years!


Thanks.
I'm here all week.
Report to moderator   Logged
WOOO
Getbig V
*****
Gender: Male
Posts: 15890


Mr. Unpopular


View Profile
« Reply #11 on: January 10, 2013, 07:09:49 PM »


Thanks.
I'm here all week.

<a href="http://www.youtube.com/watch?v=IxAKFlpdcfc" target="_blank">http://www.youtube.com/watch?v=IxAKFlpdcfc</a>
Report to moderator   Logged
panos32
Getbig II
**
Gender: Male
Posts: 58



View Profile
« Reply #12 on: February 02, 2014, 10:27:45 AM »

all supplements are garbage and a waste of money...period
Report to moderator   Logged
Montague
Moderator
Getbig V
*****
Gender: Male
Posts: 11836



View Profile
« Reply #13 on: February 02, 2014, 02:38:10 PM »

all supplements are garbage and a waste of money...period


First one of 2014!
 Grin
Report to moderator   Logged
Princess L
Moderator
Getbig V
*****
Gender: Female
Posts: 10200


I stop for turtles


View Profile
« Reply #14 on: February 02, 2014, 03:44:55 PM »

Too often we... enjoy the comfort of opinion
without the discomfort of thought.

                       John F. Kennedy

Report to moderator   Logged

:
Montague
Moderator
Getbig V
*****
Gender: Male
Posts: 11836



View Profile
« Reply #15 on: February 02, 2014, 03:53:33 PM »

Too often we... enjoy the comfort of opinion
without the discomfort of thought.

                       John F. Kennedy




Quite...
Report to moderator   Logged
Pages: [1]   Go Up
  Print  
 
Jump to:  

Theme created by Egad Community. Powered by MySQL Powered by PHP Powered by SMF 1.1.16 | SMF © 2011, Simple Machines Valid XHTML 1.0! Valid CSS!