O.K I was a guinea pig of sorts when it comes to this topical tren...the pellets....the DMSO....I would crush the pellets into a powder, and mix that with the DMSO, and then apply the solution on my thighs...wrap them with saran wrap, and let it soak in for about an hour. I had good results, as I was training for a local contest, and did fairly well.....and it did work... but I had horrible raw tender skin at the application areas. So you definitely get a dermatological reaction, but again, I was very happy with the "gains"