Any man can be defeated if his opponent lands a blow devastating enough to compromise his ability to fight back. In other words, any great fighter (be it Fedor, Overeem, Chuck Lidell, Tyson, Pacquiao, GSP) can be knocked out with a single punch if the person delivering it knows how to actually strike.
Do I believe that Ronnie Coleman would be capable of defeating any seasoned MMA fighter, regardless of weight? Not really.
Ronnie Coleman is
NOT a fighter. Being capable of lifting 200lb dumbbells will not provide for powerful strikes, on the contrary, it goes against the training philosophy boxers do in fact have.
Big (as in pro BB big) muscles in the arms does not equate to increased punching power, it actually slows you down when trying to deliver strikes.
Big (as in pro BB big) leg muscles does not provide for better leg strikes, it actually slows you down.
Could Ronnie Coleman possibly bear hug an MMA fighter, get him to gas out and then start pounding his head in? ABSOLUTELY.
The question is whether or not he can get the MMA fighter in such a predicament. I believe the MMA fighter would simply outbox him to the point where Ronnie would become much too tired and collapse due to over exhaustion.
If it goes to the ground and it is skilled MMA fighter, he would simply submit Ronnie by way of a choke or limb lock.
All that said, anything can happen in a street fight. I wouldn't underestimate anyone and do believe that one solid punch is all it takes to defeat anyone. So, whether Ronnie could defeat an MMA fighter is possible, but I peg it as highly improbable.
Again, this is just the opinion of a lonely gay man in the desert with nothing but his cock to chop down cactuses with for water.
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P.S. While far from a "real" fight, here is an example that the honorable Frozzor posted in which GSP has his way with a professional hockey player by the name of Georges Laraque. Mr. Laraque's height is 6'3 and he typically walks around at 243 lbs of weight. Notice how GSP flings him around the ring like a child and the professional athlete has no way to counter. Even if strikes were not thrown, it just goes to show that all that height and overall muscle mass means nothing when fighting against a professional MMA fighter that does this for a living.