flint, the waist starts to grow at certains doses.
biggers not always better.one can only go so far until sides and unwanted cosmetic effects happen.
but agree, starting young and running kinda wild doses will do good term if you survive it undamaged and healthy, can later on maintain almost same size on basicaly a fourth of the old doses.no idea why.
but one has to have good diet and almost kill themselves in the gym, no playing around, the high doses alone wont do shit.
true. But I was trying to make the point that very rarely is someone truly maxed out. dont quote me but from the studies we have, in humans it would take roughly 5.5 grams of testosterone to truly saturate receptors.
proof right here, that testosterone induced hypertrophy is due to an increase in satellite cells.
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Abstract
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Am J Physiol Endocrinol Metab. 2003 Jul;285(1):E197-205. Epub 2003 Apr 1.
Testosterone-induced muscle hypertrophy is associated with an increase in satellite cell number in healthy, young men.
Sinha-Hikim I, Roth SM, Lee MI, Bhasin S.
Source
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California 90059, USA.
Abstract
Testosterone (T) supplementation in men induces muscle fiber hypertrophy. We hypothesized that T-induced increase in muscle fiber size is associated with a dose-dependent increase in satellite cell number. We quantitated satellite cell and myonuclear number by using direct counting and spatial orientation methods in biopsies of vastus lateralis obtained at baseline and after 20 wk of treatment with a gonadotropin-releasing hormone agonist and a 125-, 300-, or 600-mg weekly dose of T enanthate. T administration was associated with a significant increase in myonuclear number in men receiving 300- and 600-mg doses. The posttreatment percent satellite cell number, obtained by direct counting, differed significantly among the three groups (ANCOVA P < 0.000001); the mean posttreatment values (5.0 and 15.0%) in men treated with 300- and 600-mg doses were greater than baseline (2.5 and 2.5%, respectively, P < 0.05 vs. baseline). The absolute satellite cell number measured by spatial orientation at 20 wk (1.5 and 4.0/mm) was significantly greater than baseline (0.3 and 0.6/mm) in men receiving the 300- and 600-mg doses (P < 0.05). The change in percent satellite cell number correlated with changes in total (r = 0.548) and free T concentrations (r = 0.468). Satellite cell and mitochondrial areas were significantly higher and the nuclear-to-cytoplasmic ratio lower after treatment with 300- and 600-mg doses. We conclude that T-induced muscle fiber hypertrophy is associated with an increase in satellite cell number, a proportionate increase in myonuclear number, and changes in satellite cell ultrastructure.