Bose is fine for a bedroom. For the main movie-watching room you definitely want to go with a receiver and speakers. I did a ton of research when I was putting together my home theater set-up last year. I disagree with the comment above about not noticing the difference of good speakers after a while. I am constantly impressed by how much better movies are, even ones I have seen many times before. A movie's audio is half the experience. I initially considered Bose but the components are not upgradable, and some Bose systems use hardwired cables instead of standard speaker cable (so if the cables are not long enough or need to be replaced, you're screwed).
You want to start with the best receiver you can afford, then the best subwoofer you can afford, then your front, center, and rears ( which don't have to be expensive). I went with a Denon receiver, an SVS sub, and Pioneer FS52 speakers. The best thing about going this route is that each piece can be upgraded whenever needed. With Bose what you get is what you get.