Article for the steroids creeps

[Bodybuilder Lex Reeves]

One of the primary questions often asked about anabolic steroids is how they will affect future health. As with any drug the effects of steroids depends on time and dosage; that is, how much you use and how long you use them. The higher the dose and the longer you stay on the drugs, the greater your chances of health problems.

Bodybuilders and athletes who use steroids rarely suffer serious health problems directly related to steroid use because they cycle the drugs—few stay on them year-round. Various studies have shown that most adverse changes in the body induced by steroids tend to fade when people stop using them. In short, giving the body a break from steroids enables it to repair any damage.

Some effects of high-dose steroid use are more controversial than others; for example, how steroids affect the brain. Numerous reports of out-of-control bodybuilders and other athletes on steroids have given birth to the term “roid rage.” It implies that using high-dose steroid regimens may affect the brain, causing feelings of anger and rage to be increased. Indeed, most of the wars in history have been blamed on higher testosterone levels in men.

The truth, however, is a bit more nebulous. Studies of men who lacked normal testosterone showed that having low testosterone tends to increase feelings of anger more than having normal-to-high levels. That, of course, is the opposite of what most people believe, but it makes sense when you consider all the symptoms that come with having a deficiency in testosterone, including depression and lack of sex drive. What appears to be true is that when an already angry person uses a high-dose steroid regimen, he is likely to become angrier and more reactive to things that peeve him.

That’s not to say that high-dose steroids don’t affect the brain. In recent years numerous studies, almost all involving animals, have shown definite effects, most of them negative. It appears, based on those studies, that both deficient and supernormal levels of testosterone or steroids affect the brain badly. Having too little testosterone has been linked to an increased risk for Alzheimer’s disease; however, according to a recent animal study, using high-dose steroid regimens for extended periods may set you up for the same problems.1

It has to do with the way that steroids affect a protein called nerve growth factor. The scientists who discovered NGF in the 1950s earned a Nobel Prize in physiology in 1986 for their work. As the name implies, NGF nourishes, repairs and promotes the growth of nerves. Several degenerative-brain diseases, such as Alzheimer’s, show a deficiency of NGF, suggesting that the brain is unable to repair the damage induced by Alzheimer’s. When injected into rat brains, NGF leads to a complete rapid repair of damaged neurons.

When body inflammation is increased, NGF increases, since it exerts anti-inflammatory activity. NGF is also known to set off the repair of myelin, the fatlike coating of nerves that permits nerve transmission.

Athletes lose speed with age because of the ineffective myelin repair that occurs. Basically, nerve transmissions are slowed as a result, and the physical effect is evident. (This is not to be confused with the far more pathological disease of multiple sclerosis, in which patches of myelin are destroyed as a result of a self-inflicted attack by the immune system Giving NGF to people suffering from M.S. can lead to considerable relief of symptoms.)

Although it has not been tested on athletes, NGF may, theoretically, extend the career of athletes whose sports require quick reflexes and power. Then again, not many athletes would want to have NGF injected directly into their brains—no matter how fast it made them.

Various mental diseases are related to a lack of NGF, including dementia, depression, autism, anorexia and bulimia. It’s involved in diseases not directly related to brain function as well, such as cardiovascular disease, type 2 diabetes and the metabolic syndrome. Among other functions, it interacts with insulin and can suppress excessive appetite. It can even accelerate wound healing and has been linked to feelings of being in love. It peaks during the first year of being in love and then returns to normal.

NGF interacts with two receptors in the brain. The new rat study looked at the effects of steroids on both NGF activity and brain receptors. Although this was a rat study, all of the affected structures in the brain also exist in humans. Whether the same effects would be duplicated in the human brain is probable but still speculative.

As noted, recent animal studies have shown that high-dose steroid regimens—comparable to those used by some bodybuilders and other athletes—are toxic to neurons in the brain. Some have shown that high-dose steroid use amplifies excitotoxic damage to the neurons. One example is the sudden release of the excitatory amino acid glutamate in large amounts in the brain, which commonly occurs during strokes. It’s the exposure to high levels of glutamate that leads to most of the damage or even death of brain neurons during a stroke. That doesn’t mean that the glutamic acid you get from protein foods or drinks is toxic. It relates to a large-scale release of the amino acid in the brain that is unrelated to dietary intake.

Previous animal-based studies have shown that athletic-use doses of testosterone and nandrolone (trade name Durabolin) have interfered with the activity of one of the two brain receptors for NGF. Another study showed that high-dose nandrolone and stanozolol (Winstrol) reduced levels of brain-derived neurotrophic factor in the brain. That’s problematic because BDNF is also involved in the normal maintenance of brain neurons and is increased with exercise. The study implies that using high-dose steroids may block that exercise-related benefit.

In the new study rats were injected with nandrolone and stanozolol in doses equivalent to those used in humans for athletic purposes for 28 days. The result? The steroids significantly interfered with the activity of NGF in the basal forebrain, an area of the brain that is heavily involved in intelligence and memory functions.

The steroids inhibited the transport of NGF from the hippocampus of the brain to the basal forebrain by interfering with the activity of one of the two NGF brain receptors. In doing that, they also interfered with the primary enzyme that produces acetylcholine in the brain. Acetylcholine is a brain neurotransmitter thought to be the primary neurotransmitter involved in memory and intelligence. Notably, neurons that produce acetylcholine are the most heavily damaged in Alzheimer’s disease. Most of the current drugs used to treat Alzheimer’s work by attempting to boost acetylcholine in the brain.

The loss of memory in the steroid-treated rats was reflected in their difficulty navigating a simple maze. Again, it was thought to be a result of loss of NGF activity that adversely affected acetylcholine production. The underlying cause of the whole problem, however, was likely an overactivation of androgen receptors in the brain brought on by the high-dose steroids.

This study raises two questions. First, was the negative effect on memory temporary or permanent? As noted above, most side effects linked to steroid use tend to recede when the steroid use ceases; however, that wasn’t tested here. The other salient question is whether this negative brain effect can occur in humans who are using high-dose steroids. It also suggests that those who stay on such regimens without a break are seriously risking the future health and function of their brains, as their brains will be unable to completely repair any damage that may occur due to the loss of NGF activity.

The damage can result from various factors, such as blows to the head or, less dramatically, constant attack by free radicals produced during the metabolism of oxygen. The brain is largely composed of polyunsaturated fat, which makes it more susceptible to free-radical attacks. Without NGF to repair any damage that may ensue from the constant attacks, the effects on brain function could eventually prove catastrophic.

Editor’s note: Jerry Brainum has been an exercise and nutrition researcher and journalist for more than 25 years. He’s worked with pro bodybuilders as well as many Olympic and professional athletes. To get his new e-book, Natural Anabolics —Nutrients, Compounds and Supplements That Can Accelerate Muscle Growth Without Drugs, visit www.JerryBrainum.com.   IM

 

1 Pieretti, S., et al. (2013). Brain nerve factor unbalance induced by anabolic androgenic steroids in rat. Med Sci Sports Exerc. 45:29-35

[wes]

Girls and sons who have not been loved by their fathers seek attention once teens and adults to compensate for what they didnt have originally. Fathers either left them alone, or were distant most of the time and not encouraging them. Some even despised them which would shape their personality and the way they d interact with others for the rest of their life.
They are extremistic in everything they do, always looking exageratly for attention, and have troubles adapting to society's rules, because they also have troubles defining their own identity and respecting authority and hierarchy.

Also boys who got picked on by others during childhood and adolescence -often sons without a father figure- try to compensate by lifting weights, to develop muscles and survive in ther male world. They re insecure because they re girly, childish, feminine having been raised by a single mom. They lift obsessively hoping it will transform them into men, to compensate for their lack of influence from a father figure that was not there. Unfortunaltey they can get as big as they can it doesnt cure their insecurity and who they truly are, how they grew up being raised by a single mom. They re no as manly as other men whatever they do, and they often have a big lack of masculine presence they dont know how to balance, hence often being borderline homosexuals while trying to get their manhood back thru various manly activities (mma, cars, weight lifting etc). They are often the ones that, in order to get respect from other males will go the steroids route to get even "bigger" attemptint to cure their insecurity , but being natural not being "enough", they still feel "too small", insecure, amongst other males. The lack of a father figure also often means they didnt have guidance to continue studies and are often working shitty manual jobs.

[Simple Simon]

Girls and sons who have not been loved by their fathers seek attention once teens and adults to compensate for what they didnt have originally. Fathers either left them alone, or were distant most of the time and not encouraging them. Some even despised them which would shape their personality and the way they d interact with others for the rest of their life.
They are extremistic in everything they do, always looking exageratly for attention, and have troubles adapting to society's rules, because they also have troubles defining their own identity and respecting authority and hierarchy.

Also boys who got picked on by others during childhood and adolescence -often sons without a father figure- try to compensate by lifting weights, to develop muscles and survive in ther male world. They re insecure because they re girly, childish, feminine having been raised by a single mom. They lift obsessively hoping it will transform them into men, to compensate for their lack of influence from a father figure that was not there. Unfortunaltey they can get as big as they can it doesnt cure their insecurity and who they truly are, how they grew up being raised by a single mom. They re no as manly as other men whatever they do, and they often have a big lack of masculine presence they dont know how to balance, hence often being borderline homosexuals while trying to get their manhood back thru various manly activities (mma, cars, weight lifting etc). They are often the ones that, in order to get respect from other males will go the steroids route to get even "bigger" attemptint to cure their insecurity , but being natural not being "enough", they still feel "too small", insecure, amongst other males. The lack of a father figure also often means they didnt have guidance to continue studies and are often working shitty manual jobs.

Exactly.

[Hulkotron]

Girls and sons who have not been loved by their fathers seek attention once teens and adults to compensate for what they didnt have originally. Fathers either left them alone, or were distant most of the time and not encouraging them. Some even despised them which would shape their personality and the way they d interact with others for the rest of their life.
They are extremistic in everything they do, always looking exageratly for attention, and have troubles adapting to society's rules, because they also have troubles defining their own identity and respecting authority and hierarchy.

Also boys who got picked on by others during childhood and adolescence -often sons without a father figure- try to compensate by lifting weights, to develop muscles and survive in ther male world. They re insecure because they re girly, childish, feminine having been raised by a single mom. They lift obsessively hoping it will transform them into men, to compensate for their lack of influence from a father figure that was not there. Unfortunaltey they can get as big as they can it doesnt cure their insecurity and who they truly are, how they grew up being raised by a single mom. They re no as manly as other men whatever they do, and they often have a big lack of masculine presence they dont know how to balance, hence often being borderline homosexuals while trying to get their manhood back thru various manly activities (mma, cars, weight lifting etc). They are often the ones that, in order to get respect from other males will go the steroids route to get even "bigger" attemptint to cure their insecurity , but being natural not being "enough", they still feel "too small", insecure, amongst other males. The lack of a father figure also often means they didnt have guidance to continue studies and are often working shitty manual jobs.

Precisely

[TheShape.]

Girls and sons who have not been loved by their fathers seek attention once teens and adults to compensate for what they didnt have originally. Fathers either left them alone, or were distant most of the time and not encouraging them. Some even despised them which would shape their personality and the way they d interact with others for the rest of their life.
They are extremistic in everything they do, always looking exageratly for attention, and have troubles adapting to society's rules, because they also have troubles defining their own identity and respecting authority and hierarchy.

Also boys who got picked on by others during childhood and adolescence -often sons without a father figure- try to compensate by lifting weights, to develop muscles and survive in ther male world. They re insecure because they re girly, childish, feminine having been raised by a single mom. They lift obsessively hoping it will transform them into men, to compensate for their lack of influence from a father figure that was not there. Unfortunaltey they can get as big as they can it doesnt cure their insecurity and who they truly are, how they grew up being raised by a single mom. They re no as manly as other men whatever they do, and they often have a big lack of masculine presence they dont know how to balance, hence often being borderline homosexuals while trying to get their manhood back thru various manly activities (mma, cars, weight lifting etc). They are often the ones that, in order to get respect from other males will go the steroids route to get even "bigger" attemptint to cure their insecurity , but being natural not being "enough", they still feel "too small", insecure, amongst other males. The lack of a father figure also often means they didnt have guidance to continue studies and are often working shitty manual jobs.

Scrolled down looking for this, was not disappointed. 

[wes]

[njflex]

Girls and sons who have not been loved by their fathers seek attention once teens and adults to compensate for what they didnt have originally. Fathers either left them alone, or were distant most of the time and not encouraging them. Some even despised them which would shape their personality and the way they d interact with others for the rest of their life.
They are extremistic in everything they do, always looking exageratly for attention, and have troubles adapting to society's rules, because they also have troubles defining their own identity and respecting authority and hierarchy.

Also boys who got picked on by others during childhood and adolescence -often sons without a father figure- try to compensate by lifting weights, to develop muscles and survive in ther male world. They re insecure because they re girly, childish, feminine having been raised by a single mom. They lift obsessively hoping it will transform them into men, to compensate for their lack of influence from a father figure that was not there. Unfortunaltey they can get as big as they can it doesnt cure their insecurity and who they truly are, how they grew up being raised by a single mom. They re no as manly as other men whatever they do, and they often have a big lack of masculine presence they dont know how to balance, hence often being borderline homosexuals while trying to get their manhood back thru various manly activities (mma, cars, weight lifting etc). They are often the ones that, in order to get respect from other males will go the steroids route to get even "bigger" attemptint to cure their insecurity , but being natural not being "enough", they still feel "too small", insecure, amongst other males. The lack of a father figure also often means they didnt have guidance to continue studies and are often working shitty manual jobs.

exactomundo..

[the trainer]

One of the primary questions often asked about anabolic steroids is how they will affect future health. As with any drug the effects of steroids depends on time and dosage; that is, how much you use and how long you use them. The higher the dose and the longer you stay on the drugs, the greater your chances of health problems.

Bodybuilders and athletes who use steroids rarely suffer serious health problems directly related to steroid use because they cycle the drugs—few stay on them year-round. Various studies have shown that most adverse changes in the body induced by steroids tend to fade when people stop using them. In short, giving the body a break from steroids enables it to repair any damage.

Some effects of high-dose steroid use are more controversial than others; for example, how steroids affect the brain. Numerous reports of out-of-control bodybuilders and other athletes on steroids have given birth to the term “roid rage.” It implies that using high-dose steroid regimens may affect the brain, causing feelings of anger and rage to be increased. Indeed, most of the wars in history have been blamed on higher testosterone levels in men.

The truth, however, is a bit more nebulous. Studies of men who lacked normal testosterone showed that having low testosterone tends to increase feelings of anger more than having normal-to-high levels. That, of course, is the opposite of what most people believe, but it makes sense when you consider all the symptoms that come with having a deficiency in testosterone, including depression and lack of sex drive. What appears to be true is that when an already angry person uses a high-dose steroid regimen, he is likely to become angrier and more reactive to things that peeve him.

That’s not to say that high-dose steroids don’t affect the brain. In recent years numerous studies, almost all involving animals, have shown definite effects, most of them negative. It appears, based on those studies, that both deficient and supernormal levels of testosterone or steroids affect the brain badly. Having too little testosterone has been linked to an increased risk for Alzheimer’s disease; however, according to a recent animal study, using high-dose steroid regimens for extended periods may set you up for the same problems.1

It has to do with the way that steroids affect a protein called nerve growth factor. The scientists who discovered NGF in the 1950s earned a Nobel Prize in physiology in 1986 for their work. As the name implies, NGF nourishes, repairs and promotes the growth of nerves. Several degenerative-brain diseases, such as Alzheimer’s, show a deficiency of NGF, suggesting that the brain is unable to repair the damage induced by Alzheimer’s. When injected into rat brains, NGF leads to a complete rapid repair of damaged neurons.

When body inflammation is increased, NGF increases, since it exerts anti-inflammatory activity. NGF is also known to set off the repair of myelin, the fatlike coating of nerves that permits nerve transmission.

Athletes lose speed with age because of the ineffective myelin repair that occurs. Basically, nerve transmissions are slowed as a result, and the physical effect is evident. (This is not to be confused with the far more pathological disease of multiple sclerosis, in which patches of myelin are destroyed as a result of a self-inflicted attack by the immune system Giving NGF to people suffering from M.S. can lead to considerable relief of symptoms.)

Although it has not been tested on athletes, NGF may, theoretically, extend the career of athletes whose sports require quick reflexes and power. Then again, not many athletes would want to have NGF injected directly into their brains—no matter how fast it made them.

Various mental diseases are related to a lack of NGF, including dementia, depression, autism, anorexia and bulimia. It’s involved in diseases not directly related to brain function as well, such as cardiovascular disease, type 2 diabetes and the metabolic syndrome. Among other functions, it interacts with insulin and can suppress excessive appetite. It can even accelerate wound healing and has been linked to feelings of being in love. It peaks during the first year of being in love and then returns to normal.

NGF interacts with two receptors in the brain. The new rat study looked at the effects of steroids on both NGF activity and brain receptors. Although this was a rat study, all of the affected structures in the brain also exist in humans. Whether the same effects would be duplicated in the human brain is probable but still speculative.

As noted, recent animal studies have shown that high-dose steroid regimens—comparable to those used by some bodybuilders and other athletes—are toxic to neurons in the brain. Some have shown that high-dose steroid use amplifies excitotoxic damage to the neurons. One example is the sudden release of the excitatory amino acid glutamate in large amounts in the brain, which commonly occurs during strokes. It’s the exposure to high levels of glutamate that leads to most of the damage or even death of brain neurons during a stroke. That doesn’t mean that the glutamic acid you get from protein foods or drinks is toxic. It relates to a large-scale release of the amino acid in the brain that is unrelated to dietary intake.

Previous animal-based studies have shown that athletic-use doses of testosterone and nandrolone (trade name Durabolin) have interfered with the activity of one of the two brain receptors for NGF. Another study showed that high-dose nandrolone and stanozolol (Winstrol) reduced levels of brain-derived neurotrophic factor in the brain. That’s problematic because BDNF is also involved in the normal maintenance of brain neurons and is increased with exercise. The study implies that using high-dose steroids may block that exercise-related benefit.

In the new study rats were injected with nandrolone and stanozolol in doses equivalent to those used in humans for athletic purposes for 28 days. The result? The steroids significantly interfered with the activity of NGF in the basal forebrain, an area of the brain that is heavily involved in intelligence and memory functions.

The steroids inhibited the transport of NGF from the hippocampus of the brain to the basal forebrain by interfering with the activity of one of the two NGF brain receptors. In doing that, they also interfered with the primary enzyme that produces acetylcholine in the brain. Acetylcholine is a brain neurotransmitter thought to be the primary neurotransmitter involved in memory and intelligence. Notably, neurons that produce acetylcholine are the most heavily damaged in Alzheimer’s disease. Most of the current drugs used to treat Alzheimer’s work by attempting to boost acetylcholine in the brain.

The loss of memory in the steroid-treated rats was reflected in their difficulty navigating a simple maze. Again, it was thought to be a result of loss of NGF activity that adversely affected acetylcholine production. The underlying cause of the whole problem, however, was likely an overactivation of androgen receptors in the brain brought on by the high-dose steroids.

This study raises two questions. First, was the negative effect on memory temporary or permanent? As noted above, most side effects linked to steroid use tend to recede when the steroid use ceases; however, that wasn’t tested here. The other salient question is whether this negative brain effect can occur in humans who are using high-dose steroids. It also suggests that those who stay on such regimens without a break are seriously risking the future health and function of their brains, as their brains will be unable to completely repair any damage that may occur due to the loss of NGF activity.

The damage can result from various factors, such as blows to the head or, less dramatically, constant attack by free radicals produced during the metabolism of oxygen. The brain is largely composed of polyunsaturated fat, which makes it more susceptible to free-radical attacks. Without NGF to repair any damage that may ensue from the constant attacks, the effects on brain function could eventually prove catastrophic.

Editor’s note: Jerry Brainum has been an exercise and nutrition researcher and journalist for more than 25 years. He’s worked with pro bodybuilders as well as many Olympic and professional athletes. To get his new e-book, Natural Anabolics —Nutrients, Compounds and Supplements That Can Accelerate Muscle Growth Without Drugs, visit www.JerryBrainum.com.   IM

 

1 Pieretti, S., et al. (2013). Brain nerve factor unbalance induced by anabolic androgenic steroids in rat. Med Sci Sports Exerc. 45:29-35

[liquid_c]

So, everyone who lifts weights and take steroids must have been not loved by their dad and bullied plus borderline gay and work shitty manual jobs?  OK......

[Simple Simon]

So, everyone who lifts weights and take steroids must have been not loved by their dad and bullied plus borderline gay and work shitty manual jobs?  OK......

If that doesnt include you then you must leave this forum forthwith, this forum is for losers in life only.

[El Diablo Blanco]

too many words on this page.  dnr

[Automation]

Troll fails to understand getbig, we don't read any post longer than.... Girls and sons....

[ChopperRider]

OP loves the cock.

[jon cole]

a friend of mine, 44 y.o, heavy juicer (non stop for years) + rec user in sex club died from a massive heart attack last week.

[Simple Simon]

a friend of mine, 44 y.o, heavy juicer (non stop for years) + rec user in sex club died from a massive heart attack last week.

 

[jon cole]

yep. rec are the shit.

[da_vinci]

yep. rec are the shit.

A few lines of coke makes ones heart palipitate for a few days, so it may be very well the truth.. I've seen plenty of otherwise healthy fellas barely over 30 who were on a brink of death after a night out full of booze and coke/meth..

[thebrink]

too many words on this page.  dnr

yep. I dont have time for this.

[wolfrittner]

Girls and sons who have not been loved by their fathers seek attention once teens and adults to compensate for what they didnt have originally. Fathers either left them alone, or were distant most of the time and not encouraging them. Some even despised them which would shape their personality and the way they d interact with others for the rest of their life.
They are extremistic in everything they do, always looking exageratly for attention, and have troubles adapting to society's rules, because they also have troubles defining their own identity and respecting authority and hierarchy.

Also boys who got picked on by others during childhood and adolescence -often sons without a father figure- try to compensate by lifting weights, to develop muscles and survive in ther male world. They re insecure because they re girly, childish, feminine having been raised by a single mom. They lift obsessively hoping it will transform them into men, to compensate for their lack of influence from a father figure that was not there. Unfortunaltey they can get as big as they can it doesnt cure their insecurity and who they truly are, how they grew up being raised by a single mom. They re no as manly as other men whatever they do, and they often have a big lack of masculine presence they dont know how to balance, hence often being borderline homosexuals while trying to get their manhood back thru various manly activities (mma, cars, weight lifting etc). They are often the ones that, in order to get respect from other males will go the steroids route to get even "bigger" attemptint to cure their insecurity , but being natural not being "enough", they still feel "too small", insecure, amongst other males. The lack of a father figure also often means they didnt have guidance to continue studies and are often working shitty manual jobs.