How long do you plan to keep from spending any of it? Can you tolerate a fair amount of risk, or are you more conservative? What about taxes?
If you want to keep it invested for many years to build wealth for retirement, I'd open up an IRA / Roth and put the max $5500 in it, and try to max it out every year. Put the other $19500 into a taxable account. Either hire a pro or get ready to spend many months following the markets closely, researching possible investments, and reading reputable books and articles from reputable (having a long track record of verifiable success) authors / investors.
I have taxable accounts that I invest pretty aggressively in (stocks, options, ETFs, long / short, the odd small trade or 2, etc), and tax-advantaged retirement accounts I'm more conservative in (mainly mutual funds and a gold ETF).
This is much of what I'm doing these days in my taxable accounts. My most recent purchase was $30k worth of OXY about a month ago. Just for educational purposes - NOT specific advice for you or anyone else...
Long: Pretty big positions in GLD, AAPL, IEP, UHAL, OIL, RGR, BIDU, GOOGL, CLR, SWHC, SH, OXY... Moderate positions in BRK.B, GTAT, CHK, APA, MU, SLB, HAL, NUAN, NFLX, GPOR, EOG, CAT, APC, FANG, PXD, NBR, CEO, BPL, LNG... Smaller positions in AMZN, FSLR, BLDP, TWTR, DQ... a few other stocks and commodities ETFs here and there.
Big short in JCP... Significant puts in HLF and ATHN... smaller put positions in TSLA, AMZN, NFLX, CMG, WWE, FSLR, TWTR, DQ... and a few others here and there.
