of course it can be done.
if you're talking about pro bbers, then probably not, since if they don't have it by the time you know what their name is and see them in the mags, they're not gonna do it and they've likely been 'trying' for many years.
now, if you're talking about a guy just starting out.. or even a guy with 5yrs training experience, who's NOT really tried to focus on calves, and starts to focus on them, then yea, it's possible.