Actually deregulation and degradation of AR sites has been debunked as just a myth. It is common knowledge that heavy androgen use actually increases the number of AR sites available. When people get to a stage where they are upping the dose and not seeing any gains proportioned with the increase, 9 times out of 10 it is simply that the roids are not reaching the sites to activate. Even if they do get there as in the case with heavy anabolic (low androgenic) users, the sites can fill up and there simply be no room at the inn for additional activation. But heavy androgen therapy increases that. If you are using strong androgens in large doses and not seeing gains, you are probably not eating enough. Injecting the roid in the muscle isn't all it takes. Once it reaches the bloodstream, roids must travel and reach the AR sites. The only substance in the body that is capable of picking up roid molecules for transport is the protein molecule. Nothing else can carry it. Not red blood cells, not plasma, only protein molecules. If you don't have enough binding protein levels in the body, the roids are basically sitting at the busstop for a bus that isn't coming.
I am convinced the protruding stomachs nowdays are more a direct link to IGF-1 and insulin use than GH. Even in the late 80's bodybuilders were using GH on a regular basis according to former pros. Yet you never really saw such distended guts until after the Haney, when more insulin and IGF-1 became harnessed in stacks. Insulin in small doses (under 15iu per day) can help move your bodyweight up, but if you start putting on fat from it, that a bitch to shed off. For some reason it terribly stubborn to lose. I would use it only post training, but some people use it prior to breakfast too, and in about 90% of the ones I know personally that do this, they end up with the beginning of love handles very soon.
