Side effects are dose dependent. I took a fairly low dose for over a year now under doctor's supervision with monthly bloodwork and the worst side effect I have is, wait for it - dry lips. If you have a retarded doctor who starts you on 80mg a day that might be a problem, but from what I understand (from talking to dermatologists who have used it to treat literally thousands of patients) it is a relatively safe and highly effective drug - if used properly.
I was using harsh orals non stop while on accutane (including Superdrol and M1T). I do not suggest anyone does that unless you have regular bloodwork to make sure you're okay, I'm just saying I didn't have any complications. ALT/AST below 30, yGT below 20. Was using a moderate dose of TUDCA here and there.