the only way this works is to make it an extremely raunchy & realistic adult show.
Olsen kid is a whore that drinks Fireball, doesnt work, plays on phones and take selfies all day. Older sister is loaded up on rX drugs, works at walmart. The middle sister is a banker and hates the family. Uncle jessie is a balding rock star hosting jams in the garage. The comedian guy is a terrible diabetic who might lose a leg and can't stop eating ham. The main dad, saget, he has some sick fetish he barely hides.
Id' watch that shit in a minute. But some weird wholesome family storyline? Sorry, no.